SYLVAIN MELOCHE, Ph.D.
- Principal Investigator, Signalling and Cell Growth Laboratory, Institute for Research in Immunology and Cancer
- Full Professor, Department of Pharmacology, Faculty of Medicine, Université de Montréal
AWARDS & HONOURS
- Canada Research Chair in Cellular Signalling, 2004–
- Scientist, Medical Research Council of Canada, 1998-2003
- Scholar, Medical Research Council of Canada, 1992-1997
- Joe Doupe Young Investigator Award, Canadian Society for Clinical Research, 1995
TRAINING
- Postdoctoral training with Jacques Pouysségur, Université de Nice, France, 1990-1992
- Postdoctoral training with Rafick-Pierre Sékaly, Clinical Research Institute of Montreal, 1988-1990
- Ph.D. in molecular pharmacology with Huy Ong and André De Léan, Université de Montréal, 1988
- M.Sc. in pharmaceutical science, Université de Montréal, 1984
RESEARCH SUPPORT
- Génome Québec
- Canadian Cancer Society Research Institute
- Canadian Institutes of Health Research
Sylvain Meloche is a principal investigator at the Institute for Research in Immunology and Cancer (IRIC). He is a full professor with the Department of Pharmacology of the Université de Montréal Faculty of Medicine.
Dr. Meloche’s research focuses mainly on the signalling mechanisms that control cell proliferation, the processes by which extracellular factors, such as hormones, signal the cells to multiply, differentiate, or commit suicide.
After his doctoral studies in molecular pharmacology at Université de Montréal, Dr. Meloche did his postdoctoral training in immunology at the Clinical Research Institute of Montreal, and in biochemistry at the Université de Nice, in France. Throughout this period, he was supported by the Medical Research Council of Canada and won awards from some of Canada’s most important granting agencies in recognition of the quality of his work.
In 1992, Dr. Meloche began teaching and set up research facilities at the Centre hospitalier de l’Université de Montréal. His scientific career soared when he published his team’s findings showing that MAP kinase enzymes play an essential role in the cellular proliferation process. These enzymes have since become the subject of considerable study, and Dr. Meloche’s articles on this important discovery are frequently cited in the related literature.
Since joining the ranks of IRIC in 2003, Dr. Meloche has helped identify the regulating mechanisms of protein p27 and shown that it is a significant factor in tumour development. He continues to research these mechanisms because of the protein’s great potential prognostic value. He also studies MAP kinase enzymes from a genetic perspective, particularly through the creation of mouse models that are deficient in these enzymes.
SELECTED PUBLICATIONS
Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama KI, Meloche S (2005) p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J Cell Biol 168:55-66
Meloche S. (2005) Erk3. AfCS/Nature Molecule Pages, (doi:10.1038/mp.a000876.01)
Seternes OM, Mikalsen T, Johansen B, Michaelsen E, Armstrong CG, Morrice NA, Turgeon B, Meloche S, Moens U, Keyse SM (2004) Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. Embo J 23:4780-4791
Meloche S, Vella FD, Voisin L, Ang SL, Saba-El-Leil M (2004) Erk2 signaling and early embryo stem cell self-renewal. Cell Cycle 3:241-243
Coulombe P, Rodier G, Bonneil E, Thibault P, Meloche S (2004) N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol Cell Biol 24:6140-6150
Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S (2003) An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep 4:964-968
Pelletier S, Duhamel F, Coulombe P, Popoff MR, Meloche S (2003) Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol Cell Biol 23:1316-1333
Julien C, Coulombe P, Meloche S (2003) Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. J Biol Chem 278:42615-42624
Gopalbhai K, Jansen G, Beauregard G, Whiteway M, Dumas F, Wu C, Meloche S (2003) Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1. J Biol Chem 278:8118-8125
Coulombe P, Rodier G, Pelletier S, Pellerin J, Meloche S (2003) Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Mol Cell Biol 23:4542-4558
Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S (2001) p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. Embo J 20:6672-6682
Servant MJ, Coulombe P, Turgeon B, Meloche S (2000) Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms. J Cell Biol 148:543-556
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