SYLVAIN MELOCHE, Ph.D.
- Principal Investigator, Signalling and Cell Growth research unit, Institute for Research in Immunology and Cancer
- Full Professor, Department of Pharmacology, Faculty of Medicine, Université de Montréal
AWARDS & HONOURS
- Canada Research Chair in Cellular Signalling, 2004–
- Scientist, Medical Research Council of Canada, 1998-2003
- Scholar, Medical Research Council of Canada, 1992-1997
- Joe Doupe Young Investigator Award, Canadian Society for Clinical Research, 1995
TRAINING
- Postdoctoral training with Jacques Pouysségur, Université de Nice, France, 1990-1992
- Postdoctoral training with Rafick-Pierre Sékaly,
Institut de recherches cliniques de Montréal, 1988-1990
- Ph.D. in Molecular Pharmacology with Huy Ong and André De Léan, Université de Montréal, 1988
- M.Sc. in Pharmaceutical Science, Université de Montréal, 1984
RESEARCH SUPPORT
- Génome Québec
- Canadian Cancer Society Research Institute
- Canadian Institutes of Health Research
Sylvain Meloche is a principal investigator at the Institute for Research in Immunology and Cancer (IRIC). He is a full professor with the Department of Pharmacology of the Université de Montréal Faculty of Medicine.
Dr. Meloche’s research focuses mainly on the signalling mechanisms that control cell proliferation, the processes by which extracellular factors, such as hormones, signal the cells to multiply, differentiate, or commit suicide.
After his doctoral studies in molecular pharmacology at Université de Montréal, Dr. Meloche did his postdoctoral training in immunology at the
Institut de recherches cliniques de Montréal, and in biochemistry at the Université de Nice, in France. Throughout this period, he was supported by the Medical Research Council of Canada and won awards from some of Canada’s most important granting agencies in recognition of the quality of his work.
In 1992, Dr. Meloche began teaching and set up research facilities at the Centre hospitalier de l’Université de Montréal. His scientific career soared when he published his team’s findings showing that MAP kinase enzymes play an essential role in the cellular proliferation process. These enzymes have since become the subject of considerable study, and Dr. Meloche’s articles on this important discovery are frequently cited in the related literature.
Since joining the ranks of IRIC in 2003, Dr. Meloche has helped identify the regulating mechanisms of protein p27 and shown that it is a significant factor in tumour development. He continues to research these mechanisms because of the protein’s great potential prognostic value. He also studies MAP kinase enzymes from a genetic perspective, particularly through the creation of mouse models that are deficient in these enzymes.
SELECTED PUBLICATIONS
Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KLB, Thibault P & Meloche S.
(2011).
Activation loop phosphorylation of ERK3/ERK4 by group I PAKs defines a novel PAK-ERK3/4-MK5 signaling pathway.
J Biol Chem. Dec 22. [Epub ahead of print].
Voisin L, Saba-El-Leil MK, Julien C, Frémin C & Meloche S. (2010).
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.
Mol Cell Biol. 30: 2918-2932.
Klinger S, Turgeon B, Lévesque K, Wood GA, Aagard-Tillery KM & Meloche S. (2009).
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.
Proc Natl Acad Sci USA. 106: 16710-16715.
Rodier G, Coulombe P, Tanguay P-L, Boutonnet C & Meloche S. (2008).
Phosphorylation of Skp2 Regulated by CDK2/CDK1 and Cdc14B Protects it from Degradation by APCCdh1 in G1 phase.
EMBO J. 27: 679-691.
Coulombe P & Meloche S. (2007).
Atypical mitogen-activated protein kinases: structure, regulation and functions.
Biochim Biophys Acta. 1773: 1376-1387.
Meloche S, Pouysségur J. (2007).
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1 to S phase transition.
Oncogene. 26: 3227-3239.
Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama KI & Meloche S. (2005).
p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2.
J Cell Biol. 168:55-66.
Coulombe P, Rodier G, Bonneil E, Thibault P & Meloche S. (2004).
N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.
Mol Cell Biol. 24:6140-6150.
Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL & Meloche S. (2003).
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.
EMBO Rep. 4:964-968.
Coulombe P, Rodier G, Pelletier S, Pellerin J & Meloche S. (2003).
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.
Mol Cell Biol. 23:4542-4558.
Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M & Meloche S. (2001).
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.
Embo J. 20:6672-6682.
Servant MJ, Coulombe P, Turgeon B & Meloche S. (2000).
Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms.
J Cell Biol. 148:543-556.
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