Signalling and Cell Growthunder the supervision ofSYLVAIN MELOCHE, Ph.D.
- Canada Research Chair in Cellular Signalling
- Full Professor, Department of Pharmacology, Faculty of Medicine, Université de Montréal
The expansion of cell populations is a strictly controlled process that results from the balance between cell division and cell death. In multi-cellular organisms, individual cells continuously monitor their external environment for nutrient availability and signals (mitogens, trophic factors, stress) to decide whether to self-renew, proliferate, differentiate or die. Wrong interpretation of these signals may lead to cancer.
Our research focuses on study of the signalling pathways that regulate the proliferation of mammalian cells. Specifically, our work aims to understand how cells integrate various signals coming from extra-cellular factors and intrinsic tumor suppressor gene products into the regulation of growth, cell cycle progression and survival. These mechanisms are dissected using a combination of cell biology, mouse genetics and chemical biology approaches.
T + 514 343.6966
F + 514 343.6843
sylvain.meloche@umontreal.ca |
