Postdoctoral position - Medicinal Chemistry

Please submit your application by December 30, 2021.

Only selected applicants will be contacted.

To find out about all the job opportunities, visit the career page on our site.

Job Title

Postdoctoral fellow

Administrative Unit

Drug Discovery Unit (DDU)

Mandate Description

The mission of the Drug Discovery Unit (DDU) of the Université de Montréal’s Institute for Research in Immunology and Cancer (IRIC) is to design and synthesize new small molecules having biological activity and potential therapeutic efficacy toward the development of novel treatment modalities. Its specific objective is to optimize the biological activity and pharmacological properties of so-called hit or lead compounds, identified by high-throughput screening or targeted chemical synthesis, based on a thorough investigation of their structure-activity relationships (SAR). IRIC’s DDU has openings for postdoctoral positions in medicinal chemistry in the field of drug discovery.

Under the supervision of Dr. Anne Marinier and a project leader, the incumbent will be responsible for the design, synthesis and characterization of biologically active molecules, and the interpretation of structure-activity relationships (SAR). The successful candidate will demonstrate excellent learning abilities, rapidly assimilate the biological, structural, and pharmacological aspects of his project and interact with ease in a multi-disciplinary environment. In collaboration with a supervisor, he/she will interpret biological results and participate in proposing new molecules that will drive the project forward. Excellent oral and written communication skills are essential for both presenting work to internal/external collaborators and maintaining the highest standards in reporting experiments in an electronic notebook. His/her work will be performed efficiently and in an independent manner and require minimal supervision.

Job Requirements

Education and Experience

  • Ph.D. in organic chemistry or closely related discipline (e.g. medicinal chemistry, biological chemistry);
  • Autonomy in the design of synthetic routes, problem-solving, and interpretation of results.

Skills and Abilities

  • Excellent teamwork and ability to work in a multi-disciplinary environment;
  • Excellent oral and written communication skills;
  • Initiative and creativity;
  • Problem-solving skills with minimal external input;
  • Organizational skills to maximize productivity and maintain the highest standards in experimental reporting.

Application Procedure

Interested candidates should submit a full CV, a one-page statement of research interests, and electronic copies of up to three recent publications in a single PDF attachment to the email address: pierre.louis.beaulieu@umontreal.ca

We thank all applicants for their interest. Please take note, however, that only short-listed candidates for the position will be contacted by email for an interview.

Employment Equity Program

IRIC and Université de Montréal uphold the principles of employment equity and encourage applications from women, members of visible minorities, ethnic minorities, persons with disabilities, and Aboriginal people.

Immigration Requirements

In compliance with Canadian immigration requirements, priority shall be given to Canadian citizens and permanent residents.

About Anne Marinier

Anne Marinier and her team of chemists and biologists develop two components of research linked to drug discovery.

In a first component, they design, synthesize and characterize new small molecules having biological or therapeutic activity in the area of cancer and other unmet medical needs.  Through in-depth structure-activity relationship studies, the therapeutic function of compounds known as hits, identified either during high-throughput screenings or else synthetically, is optimized to lead to compounds that are candidates for clinical trials.

The second research component bears on the design and synthesis of chemical libraries based on new structures belonging to unexplored chemical scaffolds. Following cell-based screenings, the hits coming from these libraries are used to identify new therapeutic targets following various biochemical and genetic strategies. Those new targets then play a key role in innovative therapeutic approaches to the treatment of cancer.

About IRIC

IRIC is an ultra-modern research hub and training centre located in the heart of Université de Montréal. Created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies, research at IRIC has already built a reputation for excellence within the Canadian and international scientific communities. Nearly 500 team members are dedicated to the Institute’s approach: complementary expertise, collaboration, and community combined with creativity and innovation. The next generation of investigators trained at IRIC must not only become experts in their own field, they must also integrate multidisciplinarity and collaboration into their practice. More information on postdoctoral work at UdeM can be found at : http://www.iric.ca/en/students/postdoctoral-fellowship/.

The primary objective of IRIC is to elucidate the molecular underpinnings of cancer and to devise innovative approaches to cure cancer. IRIC is located in a state-of-the-art new building on the main campus of UdeM. It currently hosts 30 Principal Investigators and over 450 trainees, graduate students, postdoctoral fellows, research associates and support staff. IRIC also comprises several cutting-edge technological platforms. These include Bioimaging, Biophysics & NMR, Flow Cytometry, Genomics, High-Throughput Screening, Histology, Proteomics, and the Drug discovery unit, as well as one of the largest animal facilities in Canada. A collegial and curiosity-driven research environment is a key characteristic of the Institute. For more information, please visit us at www.iric.ca.

About Université de Montréal

Université de Montréal is one of the leading research universities in Canada. Together with its two affiliated schools, HEC Montréal and École Polytechnique, it constitutes one of the largest centers of higher education in North America. For more information, please visit www.umontreal.ca and Research at UdeM.