Research Advisor - Medicinal Chemistry
Research Advisor (Health, Nature & Life)
Drug Discovery Unit (DDU) – Medicinal Chemistry
*Many job slots to fill*
The mission of the Drug Discovery Unit (DDU) of the Université de Montréal’s Institute for Research in Immunology and Cancer (IRIC) is to design and synthesize new small molecules having biological activity and potential therapeutic efficacy toward the development of novel treatment modalities. Its specific objective is to optimize the biological activity and pharmacological properties of so-called hit or lead compounds, identified by high-throughput screening or targeted chemical synthesis, based on a thorough investigation of their structure-activity relationships (SAR). IRIC’s DDU has openings for Research Advisor positions in organic chemistry in the field of drug discovery.
Under the supervision of the unit’s associate director and project leader, the incumbent is responsible for designing, synthesizing and characterizing new biologically active molecules. Autonomously, he/she must be able to develop the most efficient synthesis of these molecules so that a collection of analogues can be quickly prepared. He/she must also be able to assess priorities, identify and execute experiments relevant to the good progress of the project and meet deadlines. He/she will be asked to present his/her work, interpret results and propose new ideas or future plans to the research team. On certain occasions, the research advisor may have to coordinate the work of a less experienced chemist, research officer or student.
- Participate in the design and planning of new projects;
- Determine the protocols to be followed. Identify, adapt and modify techniques to obtain new types of results;
- May be asked to distribute the workload of available resources. Evaluate and validate the quality and relevance of the results obtained by the team under his/her responsibility;
- Analyze and interpret results. Propose follow-up to projects;
- Write scientific articles (project description, literature review, theoretical framework, discussion and interpretation of results);
- Present, interpret and explain the work of the laboratory during meetings, conferences, etc.;
- Write written reports (laboratory notebooks) and prepare oral presentations to provide an update on the project during regular meetings with other team members. The person holding the position may also be called upon to present the scientific results of the project in various scientific meetings or to external collaborators;
- Contribute to the design and synthesis of new molecules. Analyze and interpret biological results in relation to the structure of molecules (SAR). In collaboration with the immediate superior, propose the next analogues to be synthesized and a path forward for project progression;
- Maintain a laboratory notebook describing detailed synthetic methods, experimental results as well as the characterization of the compounds according to the required standards;
- Develop a good understanding of the biological aspects of the project (therapeutic target, biological tests, specific challenges), particularly when interpreting the results and planning activities;
- As part of the drafting of patent applications or scientific articles, participate in the drafting of the experimental part related to his/her contributions to the project;
- Meet highest industry standards in all aspects of responsibilities;
- Perform tasks to ensure the proper functioning of the laboratory (for example: maintenance of equipment, laboratory storage, inventory etc.).
Education & Experience
- Master’s degree in organic chemistry. Two years or more of experience in a field related to organic synthesis and / or medicinal chemistry that is relevant to the research project is an asset;
- Ph.D degree in organic chemistry or a specialized field related to synthetic chemistry and/or medicinal chemistry with relevance to the project is an asset.
Skills and abilities
- Great autonomy from a technical point of view and for problem solving, both for the development and optimization of syntheses and for the analysis of results and their interpretation;
- Strong team work abilities in a multidisciplinary environment;
- Strong oral and written communication skills;
- Initiative and creativity;
- Good knowledge of the principles of medicinal chemistry governing the design of new molecules for therapeutic purposes is an asset.
How to apply
Interested candidates should submit their application on the Careers website of Université de Montréal.
If you are a Université de Montréal employee, submit your application online via your Synchro self‑service.
Those for whom this is a first time request will first need to create their profile and apply to posting # 518393.
We thank all applicants for their interest. Please take note, however, that only short-listed candidates for the position will be contacted by email for an interview.
Employment Equity Program
IRIC and Université de Montréal (UdeM) uphold the principles of employment equity and encourage applications from women, members of visible minorities, ethnic minorities, persons with disabilities, and Aboriginal people.
In compliance with Canadian immigration requirements, priority shall be given to Canadian citizens and permanent residents.
About Anne Marinier
Anne Marinier and her team of chemists and biologists develop two components of research linked to drug discovery.
In a first component, they design, synthesize and characterize new small molecules having biological or therapeutic activity in the area of cancer and other unmet medical needs. Through in-depth structure-activity relationship studies, the therapeutic function of compounds known as hits, identified either during high-throughput screenings or else synthetically, is optimized to lead to compounds that are candidates for clinical trials.
The second research component bears on the design and synthesis of chemical libraries based on new structures belonging to unexplored chemical scaffolds. Following cell-based screenings, the hits coming from these libraries are used to identify new therapeutic targets following various biochemical and genetic strategies. Those new targets then play a key role in innovative therapeutic approaches to the treatment of cancer.