Principal Investigator

Michael Tyers

Systems Biology and Synthetic Biology

After earning his Ph.D. in Biochemistry at McMaster University, Michael Tyers completed postdoctoral training at the Cold Spring Harbor Laboratory, in New York. He began his career as a teacher in 1992, in the Department of Medical Genetics and Microbiology of the University of Toronto, then held the position of Principal Investigator at the Samuel Lunenfeld Research Institute. In 2007, he became Director of the Scottish Universities Life Sciences Alliance and taught systems biology at The University of Edinburgh.

Upon his return to Canada, he joined the IRIC as Principal Investigator of the Systems Biology and Synthetic Biology Research Unit. Michael Tyers is also a Professor in the Department of Medicine of the Université de Montréal.

Principal Investigator, Systems Biology and Synthetic Biology Research Unit, IRIC

Professor, Department of Medicine, Faculty of Medicine, Université de Montréal

Research unit on systems biology and synthetic biology

Pavillon Marcelle-Coutu, 4306-3

Phone (office)
(514) 343-6111, ext. 6668
Email
md.tyers@umontreal.ca
Apply for a M.Sc. or a Ph.D.

Systems Biology and Synthetic Biology

Michael Tyers and his team use biochemistry, genetics, chemical biology, microscopy, mass spectrometry and informatics to decipher how cellular networks are organized and controlled.

Research topics

Publications

  • December 23, 2019

    Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.

    Hill S, Reichermeier K, Scott DC, Samentar L, Coulombe-Huntington J, Izzi L, Tang X, Ibarra R, Bertomeu T, Moradian A, Sweredoski MJ, Caberoy N, Schulman BA, Sicheri F, Tyers M, Kleiger G
    Elife 2019-12-23 ;8:.

  • August 1, 2019

    Gene Information eXtension (GIX): effortless retrieval of gene product information on any website.

    Knight JDR, Samavarchi-Tehrani P, Tyers M, Gingras AC
    Nat. Methods 2019-08-01 ;16( 8 ):665-666.

  • July 8, 2019

    Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

    Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G
    Cancer Cell 2019-07-08 ;36( 1 ):84-99.e8.

  • April 1, 2019

    Proteome-wide, Structure-Based Prediction of Protein-Protein Interactions/New Molecular Interactions Viewer.

    Dong S, Lau V, Song R, Ierullo M, Esteban E, Wu Y, Sivieng T, Nahal H, Gaudinier A, Pasha A, Oughtred R, Dolinski K, Tyers M, Brady SM, Grene R, Usadel B, Provart NJ
    Plant Physiol. 2019-04-01 ;179( 4 ):1893-1907.

  • March 28, 2019

    The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans.

    Sellam A, Chaillot J, Mallick J, Tebbji F, Richard Albert J, Cook MA, Tyers M
    PLoS Genet. 2019-03-28 ;15( 3 ):e1008052.

  • March 1, 2019

    Drug combinations: a strategy to extend the life of antibiotics in the 21st century.

    Tyers M, Wright GD
    Nat. Rev. Microbiol. 2019-03-01 ;17( 3 ):141-155.

  • January 8, 2019

    The BioGRID interaction database: 2019 update.

    Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M
    Nucleic Acids Res. 2019-01-08 ;47( D1 ):D529-D541.

  • September 7, 2018

    Combined Enrichment/Enzymatic Approach To Study Tightly Clustered Multisite Phosphorylation on Ser-Rich Domains.

    Kanshin E, Pascariu M, Tyers M, D'Amours D, Thibault P
    J. Proteome Res. 2018-09-07 ;17( 9 ):3050-3060.

  • August 10, 2018

    Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.

    Koszela J, Pham NT, Evans D, Mann S, Perez-Pi I, Shave S, Ceccarelli DFJ, Sicheri F, Tyers M, Auer M
    BMC Biol. 2018-08-10 ;16( 1 ):88.

  • June 27, 2018

    Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability.

    Palou R, Dhanaraman T, Marrakchi R, Pascariu M, Tyers M, D'Amours D
    PLoS Biol. 2018-06-27 ;16( 6 ):e2003980.

  • See all publications

News

  • July 8, 2019

    Treatment of leukemia: IRIC Investigators publish in Cancer Cell

    Researchers at UdeM have discovered a molecular process implicated in the action of anti-leukemia drugs, opening new avenues for the development of effective treatments for this disease.

  • November 14, 2018

    Renewal Michael Tyers’ Canada Research Chair

    Michael Tyers, Principal Investigator at IRIC and Professor at the Faculty of Medicine (Université de Montréal) obtained the renewal of his research chair in Systems and Synthetic Biology.

  • See all news