IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.



A combined enrichment/enzymatic approach to study tightly clustered multi-site phosphorylation on Ser-rich domains.Kanshin E, Pascariu M, Tyers M, D'Amours D, Thibault PJ. Proteome Res. 2018-07-31.

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia.Marquis M, Beaubois C, Lavallée VP, Abrahamowicz M, Danieli C, Lemieux S, Ahmad I, Wei A, Ting SB, Fleming S, Schwarer A, Grimwade D, Grey W, Hills RK, Vyas P, Russell N, Sauvageau G, Hébert JBlood Cancer J 2018-07-19;8(8):68.

A novel differential ion mobility device expands the depth of proteome coverage and the sensitivity of multiplex proteomic measurements.Pfammatter S, Bonneil E, McManus FP, Prasad S, Bailey DJ, Belford M, Dunyach JJ, Thibault PMol. Cell Proteomics 2018-07-14.

A TFEB nuclear export signal integrates amino acid supply and glucose availability.Li L, Friedrichsen HJ, Andrews S, Picaud S, Volpon L, Ngeow K, Berridge G, Fischer R, Borden KLB, Filippakopoulos P, Goding CRNat Commun 2018-07-11;9(1):2685.

Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.Trofimova D, Paydar M, Zara A, Talje L, Kwok BH, Allingham JSNat Commun 2018-07-06;9(1):2628.

Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways.Young M, Dahoun T, Sokrat B, Arber C, Chen KM, Bouvier M, Barth PProc. Natl. Acad. Sci. U.S.A. 2018-07-03;115(27):7051-7056.

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.Chaturvedi M, Schilling J, Beautrait A, Bouvier M, Benovic JL, Shukla AKTrends Biochem. Sci. 2018-07-01;43(7):533-546.

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger ALCancer Discov 2018-07-01;8(7):866-883.

Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability.Palou R, Dhanaraman T, Marrakchi R, Pascariu M, Tyers M, D'Amours DPLoS Biol. 2018-06-27;16(6):e2003980.

Backbone assignment of the apo-form of the human C-terminal domain of UDP-glucuronosyltransferase 1A (UGT1A).Osborne MJ, Coutinho de Oliveira L, Volpon L, Borden KLBBiomol NMR Assign 2018-06-22.

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