IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.

Drug combinations: a strategy to extend the life of antibiotics in the 21st century.Tyers M, Wright GDNat. Rev. Microbiol. 2019-03-01;17(3):141-155.

GLI1-inducible glucuronidation targets a broad spectrum of drugs.Zahreddine HA, Culjkovic-Kraljacic B, Gasiorek J, Duchaine J, Borden KLBACS Chem. Biol. 2019-02-14.

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SOProc. Natl. Acad. Sci. U.S.A. 2019-02-06.

Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader SOncogene 2019-02-01;38(7):1019-1037.

Proteome-Wide, Structure-Based Prediction of Protein-protein Interactions / New Molecular Interactions Viewer.Dong S, Lau V, Song R, Ierullo M, Esteban E, Wu Y, Sivieng T, Nahal-Bose HK, Gaudinier A, Pasha A, Oughtred R, Dolinski K, Tyers M, Brady SM, Grene R, Usadel B, Provart NJPlant Physiol. 2019-01-24.

Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes.Osborne MJ, Coutinho de Oliveira L, Volpon L, Zahreddine HA, Borden KLBJ. Mol. Biol. 2019-01-18;431(2):258-272.

Reevaluation of the Role of ERK3 in Perinatal Survival and Post-Natal Growth Using New Genetically-Engineered Mouse Models.Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche SMol. Cell. Biol. 2019-01-14.

Biochemical and Structural Insights into the eukaryotic translation initiation factor eIF4E.Volpon L, Osborne MJ, Borden KLBCurr. Protein Pept. Sci. 2019-01-10.

The BioGRID interaction database: 2019 update.Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers MNucleic Acids Res. 2019-01-08;47(D1):D529-D541.

Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease.Lemieux C, Ahmad I, Bambace NM, Bernard L, Cohen S, Delisle JS, Fleury I, Kiss T, Mollica L, Roy DC, Sauvageau G, Roy J, Lachance SLeuk. Res. 2019-01-06.

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