IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.



PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila.Mehsen H, Boudreau V, Garrido D, Bourouh M, Larouche M, Maddox PS, Swan A, Archambault VJ. Cell Biol. 2018-10-11.

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick FAm. J. Med. Genet. A 2018-10-10:e40632.

Translating biased signaling in the ghrelin receptor system into differential in vivo functions.Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst BProc. Natl. Acad. Sci. U.S.A. 2018-10-09.

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Côté V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Côté JProc. Natl. Acad. Sci. U.S.A. 2018-10-02;115(40):10028-10033.

A Novel Differential Ion Mobility Device Expands the Depth of Proteome Coverage and the Sensitivity of Multiplex Proteomic Measurements.Pfammatter S, Bonneil E, McManus FP, Prasad S, Bailey DJ, Belford M, Dunyach JJ, Thibault PMol. Cell Proteomics 2018-10-01;17(10):2051-2067.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJSci Signal 2018-09-25;11(549).

Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y.Coutinho de Oliveira L, Volpon L, Osborne MJ, Borden KLBBiomol NMR Assign 2018-09-21.

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RKMol Ther Methods Clin Dev 2018-09-21;10:156-164.

The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides.Yan Y, Acevedo M, Mignacca L, Desjardins P, Scott N, Imane R, Quenneville J, Robitaille J, Feghaly A, Gagnon E, Ferbeyre G, Major FNucleic Acids Res. 2018-09-19;46(16):8181-8196.

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden KLB, Patton EE, Goding CRProc. Natl. Acad. Sci. U.S.A. 2018-09-11;115(37):E8668-E8677.

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