IRIC discoveries have spurred major advances in understanding the development of cancer and opened the way to the creation of new, more targeted therapeutic solutions. Its publications are a reflection of these accomplishments. They also demonstrate the Institute’s drive and productivity.
SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism.Nat. Genet. 2017-05-01;49(5):753-764.
Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca(2+) in Nonexcitable Cells.Mol. Pharmacol. 2017-05-01;91(5):533-544.
Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling.Hum. Mutat. 2017-05-01;38(5):569-580.
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.Mol. Cell. Biol. 2017-05-01;37(9).
RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.RNA 2017-05-01;23(5):655-672.
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.Nat Commun 2017-04-18;8:15054.
DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation.PLoS Genet. 2017-04-14;13(4):e1006738.
EPCR expression marks UM171-expanded CD34(+) cord blood stem cells.Blood 2017-04-13.
Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription.Nucleic Acids Res. 2017-04-07;45(6):3017-3030.
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.Mol. Cell Proteomics 2017-04-01;16(4):663-679.