Publication — IRIC

Bigger Isn’t Always Better: Cell Size and the Spindle Assembly Checkpoint.

Variation in the activity of the spindle assembly checkpoint has been observed in different cell types, yet the reason for this variability remains poorly understood. Reporting in Developmental Cell, Galli and Morgan (2016) show that checkpoint activity increases during development as cell size, and the cytoplasm-to-kinetochore ratio, decreases.

Publication date
February 8, 2016
Principal Investigators
Gerhold AR, Labbé J, Maddox PS
PubMed reference
Dev. Cell 2016;36(3):244-6
PubMed ID
26859348
Affiliation
Institute of Research in Immunology and Cancer (IRIC), Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada. Electronic address: abigail.gerhold@umontreal.ca.