Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.

Publication — IRIC

Celastrol, a triterpene from plants, has been used in traditional oriental medicine to treat various diseases. Here, we investigated the cardioprotective effects of celastrol against ischaemia.

Publication date: décembre 1, 2014
Principal Investigators: Der Sarkissian S, Cailhier JF, Borie M, Stevens LM, Gaboury L, Mansour S, Hamet P, Noiseux N
PubMed reference: Br. J. Pharmacol. 2014;171(23):5265-79
PubMed ID: 25041185
Affiliation: Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada; Department of Surgery, Université de Montréal, Montreal, Quebec, Canada.