Publication — IRIC

Cell coordination of collective migration by Rab11 and Moesin.

Cell migration is an important process involved in developmental events and in pathologies such as cancer. Cell migration can be classified into two types: individual and collective cell movements. Compared with individual migration, collective cell migration is less understood and has drawn increasing attention lately because of its emerging role in cancer spreading. We have recently established that Rab11 is absolutely required for spatial control of Rac1 activity through the control of cell-cell communication during collective movements (Ramel, et al. 2013). Moreover, we demonstrated that Rab11 acts through the control of Moesin activity. Here, we discuss how Rab11 and Moesin could cooperate to transfer forces from cell to cell in order to insure coordinated collective cell migration.

Publication date
July 1, 2013
Principal Investigators
Emery G, Ramel D
PubMed reference
Commun Integr Biol 2013;6(4):e24587
PubMed ID
23956813
Affiliation
Institute for Research in Immunology and Cancer (IRIC) and Department of Pathology and Cell Biology; Faculty of Medicine, Université de Montréal; Montréal, QC Canada.