Publication — IRIC

Drug combinations: a strategy to extend the life of antibiotics in the 21st century.

Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and the potential demise of many aspects of modern medicine. Despite intensive drug discovery efforts, no new classes of antibiotics have been developed into new medicines for decades, in large part owing to the stringent chemical, biological and pharmacological requisites for effective antibiotic drugs. Combinations of antibiotics and of antibiotics with non-antibiotic activity-enhancing compounds offer a productive strategy to address the widespread emergence of antibiotic-resistant strains. In this Review, we outline a theoretical and practical framework for the development of effective antibiotic combinations.

Publication date
March 1, 2019
Principal Investigators
Tyers M, Wright GD
PubMed reference
Nat. Rev. Microbiol. 2019;17(3):141-155
PubMed ID
Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec, Canada.