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Publication — IRIC

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs.

Lifelong production of the many types of mature blood cells from less differentiated progenitors is a hierarchically ordered process that spans multiple cell divisions. The nature and timing of the molecular events required to integrate the environmental signals, transcription factor activity, epigenetic modifications, and changes in gene expression involved are thus complex and still poorly understood. To address this gap, we generated comprehensive reference epigenomes of 8 phenotypically defined subsets of normal human cord blood.

Publication date
May 13, 2022
Principal Investigators
Lorzadeh A, Hammond C, Wang F, Knapp D, Wong JC, Zhu JYA, Cao Q, Heravi-Moussavi A, Carles A, Wong M, Sharafian Z, Steif J, Moksa M, Bilenky M, Lavoie PM, Eaves CJ, Hirst M
PubMed reference
BMC Biol 2022;20(1):104
PubMed ID
35550087
Affiliation
Department of Microbiology and Immunology, Michael Smith Laboratories, UBC, Vancouver, Canada.