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Publication — IRIC

Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers.

The mechanism of action of the mTOR inhibitor rapamycin is poorly understood and why certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-specific analysis of mTORC1 substrates now suggests that the sequence composition of a phosphorylation site determines whether it is sensitive to rapamycin and starvation.

Publication date
October 7, 2013
Principal Investigators
Yoon SO, Roux PP
PubMed reference
Curr. Biol. 2013;23(19):R880-3
PubMed ID
24112984
Affiliation
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: yoonsh@ucmail.uc.edu.