Publication — IRIC

The pentacyclic triterpenoid phytosterol lupeol promotes antioxidant response in the nematode C. elegans.

Plants of the Mimosa genus are studied and used for their bioactive properties. Among bioactive phytochemicals are quercetin and myricetin, which have been demonstrated to act as antioxidants in many contexts (Taheri et al. 2020; Xu et al. 2019), including in C. elegans (Buchter et al. 2013; Grünz et al. 2012; Sugawara and Sakamoto 2020). Other phytochemicals from these plants, such as the triterpenoid phytosterol lupeol, have been shown to have antioxidant properties but have not been as extensively characterized in model organisms (Liu et al. 2021; Shai et al. 2009). Here we employed the nematode C. elegans to assess whether lupeol elicits antioxidant response in vivo . Using reporter assays for oxidative stress, we find that treatment of animals with lupeol rescues some of the effects resulting from treatment with the prooxidant paraquat. Our results demonstrate that lupeol displays antioxidant properties in vivo in C. elegans .

Publication date
June 1, 2022
Principal Investigators
Voia A, Poupart V, Labbé J
PubMed reference
MicroPubl Biol 2022;2022:10.17912/micropub.biology.000581
PubMed ID
35663413
Affiliation
Collège Jean-de-Brébeuf, 3200, chemin de la Côte-Sainte-Catherine, Montréal (Québec) H3T 1C1, Canada.