Yeast Polo-like kinase substrates are nailed with the right tools.

Publication

A platform has been built combining chemical genetics and bioinformatics to screen the proteome for physiological substrates of the Polo-like kinase in budding yeast. A novel role for this kinase in regulating the mitotic spindle is revealed.

Publication date: January 1, 2008
Principal Investigators: Archambault V, Glover DM
PubMed reference: Genome Biol. 2008;9(1):203
PubMed ID: 18254925
Affiliation: Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. va228@cam.ac.uk