32 results
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis.
Uriarte M, Sen Nkwe N, Tremblay R, Ahmed O, Messmer C, Mashtalir N, Barbour H, Masclef L, Voide M, Viallard C, Daou S, Abdelhadi D, Ronato D, Paydar M, Darracq A, Boulay K, Desjardins-Lecavalier N, Sapieha P, Masson JY, Sergeev M, Kwok B, Hulea L, Mallette FA, Milot E, Larrivée B, Wurtele H, Affar EB
Nat Commun
2021-11-30
;12(
1
):6984.
Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14.
Benoit MPMH, Asenjo AB, Paydar M, Dhakal S, Kwok B, Sosa H
Nat Commun
2021-06-15
;12(
1
):3637.
BMP signaling is essential for sustaining proximo-distal progression in regenerating axolotl limbs.
Vincent E, Villiard E, Sader F, Dhakal S, Kwok B, Roy S
Development
2020-07-31
;147(
14
):.
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok B, Allingham JS, Chelly J
Hum. Mol. Genet.
2020-03-31
;29(
5
):766-784.
Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.
Zhu S, Paydar M, Wang F, Li Y, Wang L, Barrette B, Bessho T, Kwok B, Peng A
Elife
2020-01-21
;9:.
Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.
Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok B, Borden K
Proc. Natl. Acad. Sci. U.S.A.
2019-12-07
;116(
48
):24056-24065.
Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.
Reilly ML, Stokman MF, Magry V, Jeanpierre C, Alves M, Paydar M, Hellinga J, Delous M, Pouly D, Failler M, Martinovic J, Loeuillet L, Leroy B, Tantau J, Roume J, Gregory-Evans CY, Shan X, Filges I, Allingham JS, Kwok B, Saunier S, Giles RH, Benmerah A
Hum. Mol. Genet.
2019-03-01
;28(
5
):778-795.
Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.
Trofimova D, Paydar M, Zara A, Talje L, Kwok B, Allingham JS
Nat Commun
2018-07-06
;9(
1
):2628.
DHTP is an allosteric inhibitor of the kinesin-13 family of microtubule depolymerases.
Talje L, El Kadhi KB, Atchia K, Tremblay-Boudreault T, Carréno S, Kwok B
FEBS Lett
2017-08-30
;591(
18
):2952.
Multimodal and Polymorphic Interactions between Anillin and Actin: Their Implications for Cytokinesis.
Jananji S, Risi C, Lindamulage IK, Picard LP, Van Sciver R, Laflamme G, Albaghjati A, Hickson GR, Kwok B, Galkin VE
J. Mol. Biol.
2017-03-10
;429(
5
):715-731.
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.
Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok B, Roux PP, Hoang T
J. Clin. Invest.
2016-12-01
;126(
12
):4569-4584.
Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.
Orr B, Talje L, Liu Z, Kwok B, Compton DA
Cell Rep
2016-11-08
;17(
7
):1755-1763.
Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.
Kachaner D, Pinson X, El Kadhi KB, Normandin K, Talje L, Lavoie H, Lépine G, Carréno S, Kwok B, Hickson GR, Archambault V
J. Cell Biol.
2014-10-27
;207(
2
):201-11.
Structural Maintenance of Chromosome (SMC) Proteins Link Microtubule Stability to Genome Integrity.
Laflamme G, Tremblay-Boudreault T, Roy MA, Andersen P, Bonneil E, Atchia K, Thibault P, D'Amours D, Kwok B
J. Biol. Chem.
2014-10-03
;289(
40
):27418-31.
KIF14 Binds Tightly to Microtubules and Adopts a Rigor-Like Conformation.
Arora K, Talje L, Asenjo AB, Andersen P, Atchia K, Joshi M, Sosa H, Allingham JS, Kwok B
J. Mol. Biol.
2014-08-26
;426(
17
):2997-3015.
DHTP is an allosteric inhibitor of the kinesin-13 family of microtubule depolymerases.
Talje L, Ben El Kadhi K, Atchia K, Tremblay-Boudreault T, Carréno S, Kwok B
FEBS Lett.
2014-06-27
;588(
14
):2315-20.
The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex.
Solinet S, Mahmud K, Stewman SF, Ben El Kadhi K, Decelle B, Talje L, Ma A, Kwok B, Carréno S
J. Cell Biol.
2013-07-22
;202(
2
):251-60.
Microtubule cross-linking triggers the directional motility of kinesin-5.
Kapitein LC, Kwok B, Weinger JS, Schmidt CF, Kapoor TM, Peterman EJ
J. Cell Biol.
2008-08-11
;182(
3
):421-8.
Efficient identification of phosphorylation by mass spectrometric phosphopeptide fingerprinting.
Woo EM, Fenyo D, Kwok B, Funabiki H, Chait BT
Anal. Chem.
2008-04-01
;80(
7
):2419-25.
Microtubule flux: drivers wanted.
Kwok B, Kapoor TM
Curr. Opin. Cell Biol.
2007-02-01
;19(
1
):36-42.
Probing cell-division phenotype space and Polo-like kinase function using small molecules.
Peters U, Cherian J, Kim JH, Kwok B, Kapoor TM
Nat. Chem. Biol.
2006-11-01
;2(
11
):618-26.
Allosteric inhibition of kinesin-5 modulates its processive directional motility.
Kwok B, Kapitein LC, Kim JH, Peterman EJ, Schmidt CF, Kapoor TM
Nat. Chem. Biol.
2006-09-01
;2(
9
):480-5.
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.
Kapitein LC, Peterman EJ, Kwok B, Kim JH, Kapoor TM, Schmidt CF
Nature
2005-05-05
;435(
7038
):114-8.
The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.
Kwok B, Yang JG, Kapoor TM
Curr. Biol.
2004-10-05
;14(
19
):1783-8.
Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR.
Lin S, Yang ZQ, Kwok B, Koldobskiy M, Crews CM, Danishefsky SJ
J. Am. Chem. Soc.
2004-05-26
;126(
20
):6347-55.
Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm.
Han YG, Kwok B, Kernan MJ
Curr. Biol.
2003-09-30
;13(
19
):1679-86.
Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity.
Yang ZQ, Kwok B, Lin S, Koldobskiy MA, Crews CM, Danishefsky SJ
Chembiochem
2003-06-06
;4(
6
):508-13.
Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13.
Ndubuisil MI, Kwok B, Vervoort J, Koh BD, Elofsson M, Crews CM
Biochemistry
2002-06-18
;41(
24
):7841-8.
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.
Kwok B, Koh B, Ndubuisi MI, Elofsson M, Crews CM
Chem. Biol.
2001-08-01
;8(
8
):759-66.
Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity.
Meng L, Mohan R, Kwok B, Elofsson M, Sin N, Crews CM
Proc. Natl. Acad. Sci. U.S.A.
1999-08-31
;96(
18
):10403-8.
Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology.
Sin N, Kim KB, Elofsson M, Meng L, Auth H, Kwok B, Crews CM
Bioorg. Med. Chem. Lett.
1999-08-02
;9(
15
):2283-8.
Eponemycin exerts its antitumor effect through the inhibition of proteasome function.
Meng L, Kwok B, Sin N, Crews CM
Cancer Res.
1999-06-15
;59(
12
):2798-801.