138 results
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP
Nat Commun
2020-07-24
;11(
1
):3701.
Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.
Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche S
Mol. Cell. Biol.
2019-03-15
;39(
6
):.
A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.
Fink S, Zugelder L, Roth B, Brandt E, Meloche S, Izsvák Z, Bargou RC, Stühmer T
PLoS ONE
2018-10-19
;13(
10
):e0205585.
Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.
Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit R
Mol. Cell. Biol.
2017-12-15
;37(
24
):.
Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.
Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD
Bioconjug. Chem.
2017-06-21
;28(
6
):1677-1683.
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.
Mathien S, Déléris P, Soulez M, Voisin L, Meloche S
Mol. Cell. Biol.
2017-05-01
;37(
9
):.
Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling.
Saba-El-Leil MK, Frémin C, Meloche S
Methods Mol. Biol.
2017-01-01
;1487:243-253.
ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.
Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche S
Oncogene
2016-10-27
;35(
43
):5692-5698.
Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.
Pew BK, Harris RA, Sbrana E, Guaman MC, Shope C, Chen R, Meloche S, Aagaard K
Am. J. Obstet. Gynecol.
2016-09-01
;215(
3
):384.e1-384.e89.
Redundancy in the World of MAP Kinases: All for One.
Saba-El-Leil MK, Frémin C, Meloche S
Front Cell Dev Biol
2016-06-27
;4:67.
Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.
Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche S
Cell Cycle
2016-06-17
;15(
12
):1631-42.
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.
Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G
Blood
2016-06-16
;127(
24
):3054-61.
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G
Nat. Genet.
2015-09-01
;47(
9
):1030-7.
Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development.
Frémin C, Saba-El-Leil MK, Lévesque K, Ang SL, Meloche S
Cell Rep
2015-08-11
;12(
6
):913-21.
The atypical MAPK ERK3 controls positive selection of thymocytes.
Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque N
Immunology
2015-05-01
;145(
1
):161-9.
E4F1 Is a Master Regulator of CHK1-Mediated Functions.
Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G
Cell Rep
2015-04-15
;11(
2
):210-219.
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau G, Boutonnet C, Meloche S, Sauvageau G
Blood
2014-10-09
;124(
15
):2362-9.
The Catalytic Activity of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 3 Is Required To Sustain CD4+ CD8+ Thymocyte Survival.
Marquis M, Daudelin JF, Boulet S, Sirois J, Crain K, Mathien S, Turgeon B, Rousseau J, Meloche S, Labrecque N
Mol. Cell. Biol.
2014-09-15
;34(
18
):3374-87.
Towards the development of chromone-based MEK1/2 modulators.
Redwan IN, Dyrager C, Solano C, Fernández de Trocóniz G, Voisin L, Bliman D, Meloche S, Grøtli M
Eur J Med Chem
2014-07-07
;85C:127-138.
Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.
Cuevas Guaman M, Sbrana E, Shope C, Showalter L, Hu M, Meloche S, Aagaard K
Pediatr. Res.
2014-07-01
;76(
1
):24-32.
The Non-Classical MAP Kinase ERK3 Controls T Cell Activation.
Marquis M, Boulet S, Mathien S, Rousseau J, Thébault P, Daudelin JF, Rooney J, Turgeon B, Beauchamp C, Meloche S, Labrecque N
PLoS ONE
2014-01-27
;9(
1
):e86681.
ERKs in Cancer: Friends or Foes?
Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G
Cancer Res.
2014-01-15
;74(
2
):412-9.
NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.
Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J
Blood
2013-06-27
;121(
26
):5203-7.
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden K, Meloche S, Roux PP
Oncogene
2013-06-13
;32(
24
):2917-26.
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.
Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G
Genes Dev.
2013-04-15
;27(
8
):900-15.
Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.
Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault P
Mol. Syst. Biol.
2013-01-01
;9:669.
Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.
Trost M, Sauvageau G, Hérault O, Deleris P, Pomiès C, Chagraoui J, Mayotte N, Meloche S, Sauvageau G, Thibault P
Blood
2012-08-23
;120(
8
):e17-27.
Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity.
van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ
PLoS Pathog.
2012-07-01
;8(
7
):e1002747.
The Extracellular Signal-Regulated Kinase 3 (Mitogen-Activated Protein Kinase 6 [MAPK6])-MAPK-Activated Protein Kinase 5 Signaling Complex Regulates Septin Function and Dendrite Morphology.
Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A
Mol. Cell. Biol.
2012-07-01
;32(
13
):2467-78.
Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S
Cancer Res.
2012-02-01
;72(
3
):626-35.
F-box proteins elongate translation during stress recovery.
Meloche S, Roux PP
Sci Signal
2012-01-01
;5(
227
):pe25.
Liver fibrosis protects mice from acute hepatocellular injury.
Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M
Gastroenterology
2012-01-01
;142(
1
):130-139.e4.
ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses.
Courcelles M, Lemieux S, Voisin L, Meloche S, Thibault P
Proteomics
2011-07-01
;11(
13
):2654-71.
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F
Cell
2011-06-24
;145(
7
):1075-87.
Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden K, Thibault P, Meloche S
J. Biol. Chem.
2011-02-25
;286(
8
):6470-8.
A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.
Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P
Mol. Cell Proteomics
2011-02-01
;10(
2
):M110.004796.
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.
Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD
Circ. Res.
2011-01-21
;108(
2
):176-83.
Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.
Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche S
Mol. Cell. Biol.
2010-12-01
;30(
24
):5752-63.
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.
Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche S
Mol. Cell. Biol.
2010-06-01
;30(
12
):2918-32.
C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.
Tanguay PL, Rodier G, Meloche S
Biochem. J.
2010-05-15
;428(
1
):103-11.
Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.
Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S
Cell Cycle
2010-03-01
;9(
5
):975-9.
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.
Frémin C, Meloche S
J Hematol Oncol
2010-01-01
;3:8.
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.
Klinger S, Turgeon B, Lévesque K, Wood GA, Aagaard-Tillery KM, Meloche S
Proc. Natl. Acad. Sci. U.S.A.
2009-09-29
;106(
39
):16710-5.
Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant.
White M, Ross H, Levesque S, Whittom L, Pelletier GB, Racine N, Meloche S, Voisin L
Ann Pharmacother
2009-05-01
;43(
5
):831-9.
Artifactual sulfation of silver-stained proteins: implications for the assignment of phosphorylation and sulfation sites.
Gharib M, Marcantonio M, Lehmann SG, Courcelles M, Meloche S, Verreault A, Thibault P
Mol. Cell Proteomics
2009-03-01
;8(
3
):506-18.
ER stress affects processing of MHC class I-associated peptides.
Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault C
BMC Immunol.
2009-01-01
;10:10.
Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.
Turgeon B, Meloche S
Physiol. Rev.
2009-01-01
;89(
1
):1-26.
[Cdc14B/Skp2/p27 : a novel cancer axis of evil?]
Coulombe P, Rodier G, Meloche S
Med Sci (Paris)
2009-01-01
;25(
8-9
):673-5.
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.
Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay PL, Meloche S
J. Cell. Physiol.
2008-12-01
;217(
3
):778-88.
The IKK-related kinases: from innate immunity to oncogenesis.
Clément JF, Meloche S, Servant MJ
Cell Res.
2008-09-01
;18(
9
):889-99.