IRIC - Institute for Research in Immunology and Cancer

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144 results


Publications — IRIC April 1, 2022

ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation.

Soulez M, Tanguay PL, Dô F, Dort J, Crist C, Kotlyarov A, Gaestel M, Ferron M, Dumont NA, Meloche S
J Cell Physiol 2022-04-01 ;237( 4 ):2271-2287.


Publications — IRIC March 25, 2022

Development of a high-throughput assay to identify inhibitors of the ubiquitin-conjugating enzyme UBCH10.

Cléroux P, Voisin L, Meloche S
SLAS Discov 2022-03-25 ;.


Publications — IRIC January 18, 2022

Signaling by the tyrosine kinase Yes promotes liver cancer development.

Guégan JP, Lapouge M, Voisin L, Saba-El-Leil MK, Tanguay PL, Lévesque K, Brégeon J, Mes-Masson AM, Lamarre D, Haibe-Kains B, Trinh VQ, Soucy G, Bilodeau M, Meloche S
Sci Signal 2022-01-18 ;15( 717 ):eabj4743.


Publications — IRIC October 1, 2021

Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential.

Mathien S, Tesnière C, Meloche S
Pharmacol Rev 2021-10-01 ;73( 4 ):263-296.


Publications — IRIC March 23, 2021

Interleukin-17 Receptor D in Physiology, Inflammation and Cancer.

Girondel C, Meloche S
Front Oncol 2021-03-23 ;11:656004.


Publications — IRIC January 1, 2021

Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.

Girondel C, Lévesque K, Langlois MJ, Pasquin S, Saba-El-Leil MK, Rivard N, Friesel R, Servant MJ, Gauchat JF, Lesage S, Meloche S
Oncogene 2021-01-01 ;40( 2 ):452-464.


Publications — IRIC July 24, 2020

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.

Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP
Nat Commun 2020-07-24 ;11( 1 ):3701.


Publications — IRIC March 15, 2019

Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.

Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche S
Mol. Cell. Biol. 2019-03-15 ;39( 6 ):.


Publications — IRIC October 19, 2018

A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.

Fink S, Zugelder L, Roth B, Brandt E, Meloche S, Izsvák Z, Bargou RC, Stühmer T
PLoS ONE 2018-10-19 ;13( 10 ):e0205585.


Publications — IRIC December 15, 2017

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.

Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit R
Mol. Cell. Biol. 2017-12-15 ;37( 24 ):.


Publications — IRIC June 21, 2017

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD
Bioconjug. Chem. 2017-06-21 ;28( 6 ):1677-1683.


Publications — IRIC May 1, 2017

Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.

Mathien S, Déléris P, Soulez M, Voisin L, Meloche S
Mol. Cell. Biol. 2017-05-01 ;37( 9 ):.


Publications — IRIC January 1, 2017

Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling.

Saba-El-Leil MK, Frémin C, Meloche S
Methods Mol. Biol. 2017-01-01 ;1487:243-253.


Publications — IRIC October 27, 2016

ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.

Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche S
Oncogene 2016-10-27 ;35( 43 ):5692-5698.


Publications — IRIC September 1, 2016

Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.

Pew BK, Harris RA, Sbrana E, Guaman MC, Shope C, Chen R, Meloche S, Aagaard K
Am. J. Obstet. Gynecol. 2016-09-01 ;215( 3 ):384.e1-384.e89.


Publications — IRIC June 27, 2016

Redundancy in the World of MAP Kinases: All for One.

Saba-El-Leil MK, Frémin C, Meloche S
Front Cell Dev Biol 2016-06-27 ;4:67.


Publications — IRIC June 17, 2016

Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.

Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche S
Cell Cycle 2016-06-17 ;15( 12 ):1631-42.


Publications — IRIC June 16, 2016

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.

Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G
Blood 2016-06-16 ;127( 24 ):3054-61.


Publications — IRIC September 1, 2015

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G
Nat. Genet. 2015-09-01 ;47( 9 ):1030-7.


Publications — IRIC August 11, 2015

Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development.

Frémin C, Saba-El-Leil MK, Lévesque K, Ang SL, Meloche S
Cell Rep 2015-08-11 ;12( 6 ):913-21.


Publications — IRIC May 1, 2015

The atypical MAPK ERK3 controls positive selection of thymocytes.

Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque N
Immunology 2015-05-01 ;145( 1 ):161-9.


Publications — IRIC April 15, 2015

E4F1 Is a Master Regulator of CHK1-Mediated Functions.

Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G
Cell Rep 2015-04-15 ;11( 2 ):210-219.


Publications — IRIC October 9, 2014

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau G, Boutonnet C, Meloche S, Sauvageau G
Blood 2014-10-09 ;124( 15 ):2362-9.


Publications — IRIC September 15, 2014

The Catalytic Activity of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 3 Is Required To Sustain CD4+ CD8+ Thymocyte Survival.

Marquis M, Daudelin JF, Boulet S, Sirois J, Crain K, Mathien S, Turgeon B, Rousseau J, Meloche S, Labrecque N
Mol. Cell. Biol. 2014-09-15 ;34( 18 ):3374-87.


Publications — IRIC July 7, 2014

Towards the development of chromone-based MEK1/2 modulators.

Redwan IN, Dyrager C, Solano C, Fernández de Trocóniz G, Voisin L, Bliman D, Meloche S, Grøtli M
Eur J Med Chem 2014-07-07 ;85C:127-138.


Publications — IRIC July 1, 2014

Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.

Cuevas Guaman M, Sbrana E, Shope C, Showalter L, Hu M, Meloche S, Aagaard K
Pediatr. Res. 2014-07-01 ;76( 1 ):24-32.


Publications — IRIC January 27, 2014

The Non-Classical MAP Kinase ERK3 Controls T Cell Activation.

Marquis M, Boulet S, Mathien S, Rousseau J, Thébault P, Daudelin JF, Rooney J, Turgeon B, Beauchamp C, Meloche S, Labrecque N
PLoS ONE 2014-01-27 ;9( 1 ):e86681.


Publications — IRIC January 15, 2014

ERKs in Cancer: Friends or Foes?

Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G
Cancer Res. 2014-01-15 ;74( 2 ):412-9.


Publications — IRIC June 27, 2013

NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.

Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J
Blood 2013-06-27 ;121( 26 ):5203-7.


Publications — IRIC June 13, 2013

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.

Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden K, Meloche S, Roux PP
Oncogene 2013-06-13 ;32( 24 ):2917-26.


Publications — IRIC April 15, 2013

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G
Genes Dev. 2013-04-15 ;27( 8 ):900-15.


Publications — IRIC January 1, 2013

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.

Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault P
Mol. Syst. Biol. 2013-01-01 ;9:669.


Publications — IRIC August 23, 2012

Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.

Trost M, Sauvageau G, Hérault O, Deleris P, Pomiès C, Chagraoui J, Mayotte N, Meloche S, Sauvageau G, Thibault P
Blood 2012-08-23 ;120( 8 ):e17-27.


Publications — IRIC July 1, 2012

Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity.

van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ
PLoS Pathog. 2012-07-01 ;8( 7 ):e1002747.


Publications — IRIC July 1, 2012

The Extracellular Signal-Regulated Kinase 3 (Mitogen-Activated Protein Kinase 6 [MAPK6])-MAPK-Activated Protein Kinase 5 Signaling Complex Regulates Septin Function and Dendrite Morphology.

Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A
Mol. Cell. Biol. 2012-07-01 ;32( 13 ):2467-78.


Publications — IRIC February 1, 2012

Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.

Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S
Cancer Res. 2012-02-01 ;72( 3 ):626-35.


Publications — IRIC January 1, 2012

F-box proteins elongate translation during stress recovery.

Meloche S, Roux PP
Sci Signal 2012-01-01 ;5( 227 ):pe25.


Publications — IRIC January 1, 2012

Liver fibrosis protects mice from acute hepatocellular injury.

Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M
Gastroenterology 2012-01-01 ;142( 1 ):130-139.e4.


Publications — IRIC July 1, 2011

ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses.

Courcelles M, Lemieux S, Voisin L, Meloche S, Thibault P
Proteomics 2011-07-01 ;11( 13 ):2654-71.


Publications — IRIC June 24, 2011

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F
Cell 2011-06-24 ;145( 7 ):1075-87.


Publications — IRIC February 25, 2011

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.

Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden K, Thibault P, Meloche S
J. Biol. Chem. 2011-02-25 ;286( 8 ):6470-8.


Publications — IRIC February 1, 2011

A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.

Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P
Mol. Cell Proteomics 2011-02-01 ;10( 2 ):M110.004796.


Publications — IRIC January 21, 2011

Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.

Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD
Circ. Res. 2011-01-21 ;108( 2 ):176-83.


Publications — IRIC December 1, 2010

Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.

Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche S
Mol. Cell. Biol. 2010-12-01 ;30( 24 ):5752-63.


Publications — IRIC June 1, 2010

Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.

Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche S
Mol. Cell. Biol. 2010-06-01 ;30( 12 ):2918-32.


Publications — IRIC May 15, 2010

C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.

Tanguay PL, Rodier G, Meloche S
Biochem. J. 2010-05-15 ;428( 1 ):103-11.


Publications — IRIC March 1, 2010

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.

Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S
Cell Cycle 2010-03-01 ;9( 5 ):975-9.


Publications — IRIC January 1, 2010

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.

Frémin C, Meloche S
J Hematol Oncol 2010-01-01 ;3:8.


Publications — IRIC September 29, 2009

Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.

Klinger S, Turgeon B, Lévesque K, Wood GA, Aagaard-Tillery KM, Meloche S
Proc. Natl. Acad. Sci. U.S.A. 2009-09-29 ;106( 39 ):16710-5.


Publications — IRIC May 1, 2009

Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant.

White M, Ross H, Levesque S, Whittom L, Pelletier GB, Racine N, Meloche S, Voisin L
Ann Pharmacother 2009-05-01 ;43( 5 ):831-9.

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Sylvain Meloche
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