IRIC - Institute for Research in Immunology and Cancer

Primary navigation

  • About
    • Our Institute
    • Governance
    • News
    • Events
    • Grants
  • Research
    • Importance of research
    • Principal Investigators
    • Research topics
    • Platforms and infrastructures
    • Publications
    • Lectures
  • Training
    • Study at IRIC
    • Our programs
    • Submit your application
  • Valorization
  • Careers
    • Available positions
    • Spontaneous application
  • Support research
    • Make a donation
    • Get involved
    • Other ways to give
    • Donor impact
    • Our donors
  • Directory
  • Tools
  • Press
  • Contact
  • IRIC is 20!
  • Support research
    • Make a donation
    • Get involved
    • Other ways to give
    • Donor impact
    • Our donors
  • Search
  • FR

Breadcrumb

  • Home
  • Search
  • Home

Search

45 results


Publications — IRIC August 23, 2022

HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.

Moison C, Spinella JF, Chagraoui J, Lavallée VP, Lehnertz B, Thiollier C, Boivin I, Mayotte N, MacRae T, Marinier A, Hébert J, Sauvageau G
Blood Adv 2022-08-23 ;6( 16 ):4793-4806.


Publications — IRIC July 14, 2022

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.

Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier A
J Med Chem 2022-07-14 ;65( 13 ):8843-8854.


Publications — IRIC May 19, 2022

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.

Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du D, Yang JJ, Hoff FW, Kaminski M, Tomczak K, Eric Davis R, Herranz D, Ferrando A, Jabbour EJ, Emilia Di Francesco M, Teachey DT, Horton TM, Kornblau S, Rezvani K, Sauvageau G, Gagea M, Andreeff M, Takahashi K, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva M
Nat Commun 2022-05-19 ;13( 1 ):2801.


Publications — IRIC January 25, 2022

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.

Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau G
Blood Adv 2022-01-25 ;6( 2 ):509-514.


Publications — IRIC October 29, 2021

Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.

St-Cyr D, Ceccarelli DF, Orlicky S, van der Sloot AM, Tang X, Kelso S, Moore S, James C, Posternak G, Coulombe-Huntington J, Bertomeu T, Marinier A, Sicheri F, Tyers M
Sci Adv 2021-10-29 ;7( 44 ):eabi5797.


Publications — IRIC August 3, 2021

Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.

Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA
Nat Commun 2021-08-03 ;12( 1 ):4688.


Publications — IRIC January 7, 2021

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.

Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau G
Cell Stem Cell 2021-01-07 ;28( 1 ):48-62.e6.


Publications — IRIC November 12, 2020

Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.

Toulouse JL, Shi G, Lemay-St-Denis C, Ebert MCCJC, Deon D, Gagnon M, Ruediger E, Saint-Jacques K, Forge D, Vanden Eynde JJ, Marinier A, Ji X, Pelletier JN
ACS Med Chem Lett 2020-11-12 ;11( 11 ):2261-2267.


Publications — IRIC January 31, 2020

Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.

Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G
Lancet Haematol 2020-01-31 ;7( 2 ):e134-e145.


Publications — IRIC December 19, 2019

Genetic characterization of ABT-199 sensitivity in human AML.

Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D'Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G
Leukemia 2019-12-19 ;34( 1 ):63-74.


Publications — IRIC August 22, 2019

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.

Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A
J. Med. Chem. 2019-08-22 ;62( 16 ):7400-7416.


Publications — IRIC July 15, 2019

Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.

Labelle C, Marinier A, Lemieux S
Bioinformatics 2019-07-15 ;35( 14 ):i464-i473.


Publications — IRIC July 8, 2019

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G
Cancer Cell 2019-07-08 ;36( 1 ):84-99.e8.


Publications — IRIC June 30, 2019

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.

Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN
ACS Omega 2019-06-30 ;4( 6 ):10056-10069.


Publications — IRIC April 5, 2019

Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.

Cyr P, Flynn-Robitaille J, Boissarie P, Marinier A
Org. Lett. 2019-04-05 ;21( 7 ):2265-2268.


Publications — IRIC April 2, 2019

Identification of Allosteric Inhibitors against Active Caspase-6.

Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC
Sci Rep 2019-04-02 ;9( 1 ):5504.


Publications — IRIC February 26, 2019

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.

Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G
Blood Adv 2019-02-26 ;3( 4 ):552-563.


Publications — IRIC June 1, 2018

Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.

Lavallée VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GÉ, Hébert J, Sauvageau G
Leukemia 2018-06-01 ;32( 6 ):1349-1357.


Publications — IRIC November 15, 2017

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.

Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau G
Clin. Cancer Res. 2017-11-15 ;23( 22 ):6969-6981.


Publications — IRIC February 17, 2017

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.

Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G
Blood Cancer J 2017-02-17 ;7( 2 ):e529.


Publications — IRIC January 4, 2017

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.

Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J
Sci Transl Med 2017-01-04 ;9( 371 ):.


Publications — IRIC December 1, 2016

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok B, Roux PP, Hoang T
J. Clin. Invest. 2016-12-01 ;126( 12 ):4569-4584.


Publications — IRIC November 22, 2016

Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.

Normandin K, Lavallée JF, Futter M, Beautrait A, Duchaine J, Guiral S, Marinier A, Archambault V
Sci Rep 2016-11-22 ;5:37581.


Publications — IRIC June 16, 2016

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.

Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G
Blood 2016-06-16 ;127( 24 ):3054-61.


Publications — IRIC September 1, 2015

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G
Nat. Genet. 2015-09-01 ;47( 9 ):1030-7.


Publications — IRIC January 1, 2015

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.

Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M
Nat. Struct. Mol. Biol. 2015-01-01 ;22( 1 ):37-43.


Publications — IRIC September 19, 2014

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp D, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G
Science 2014-09-19 ;345( 6203 ):1509-12.


Publications — IRIC April 1, 2014

Identification of small molecules that support human leukemia stem cell activity ex vivo.

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G
Nat. Methods 2014-04-01 ;11( 4 ):436-42.


Publications — IRIC February 1, 2014

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F
Nat. Chem. Biol. 2014-02-01 ;10( 2 ):156-63.


Publications April 9, 2009

Novel tricyclic inhibitors of IkappaB kinase.

Kempson J, Spergel SH, Guo J, Quesnelle C, Gill P, Belanger D, Dyckman AJ, Li T, Watterson SH, Langevine CM, Das J, Moquin RV, Furch JA, Marinier A, Dodier M, Martel A, Nirschl D, Van Kirk K, Burke JR, Pattoli MA, Gillooly K, McIntyre KW, Chen L, Yang Z, Marathe PH, Wang-Iverson D, Dodd JH, McKinnon M, Barrish JC, Pitts WJ
J. Med. Chem. 2009-04-09 ;52( 7 ):1994-2005.


Publications June 2, 2005

Biaryl isoxazolinone antibacterial agents.

Quesnelle CA, Gill P, Roy S, Dodier M, Marinier A, Martel A, Snyder LB, D'Andrea SV, Bronson JJ, Frosco M, Beaulieu D, Warr GA, Denbleyker KL, Stickle TM, Yang H, Chaniewski SE, Ferraro CA, Taylor D, Russell JW, Santone KS, Clarke J, Drain RL, Knipe JO, Mosure K, Barrett JF
Bioorg. Med. Chem. Lett. 2005-06-02 ;15( 11 ):2728-33.


Publications September 20, 2004

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.

Snyder LB, Meng Z, Mate R, D'Andrea SV, Marinier A, Quesnelle CA, Gill P, DenBleyker KL, Fung-Tomc JC, Frosco M, Martel A, Barrett JF, Bronson JJ
Bioorg. Med. Chem. Lett. 2004-09-20 ;14( 18 ):4735-9.


Publications September 1, 2004

Rational design of RAR-selective ligands revealed by RARbeta crystal stucture.

Germain P, Kammerer S, Pérez E, Peluso-Iltis C, Tortolani D, Zusi FC, Starrett J, Lapointe P, Daris JP, Marinier A, de Lera AR, Rochel N, Gronemeyer H
EMBO Rep. 2004-09-01 ;5( 9 ):877-82.


Publications April 17, 2003

Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.

Serrano-Wu MH, Laurent DR, Carroll TM, Dodier M, Gao Q, Gill P, Quesnelle C, Marinier A, Mazzucco CE, Regueiro-Ren A, Stickle TM, Wu D, Yang H, Yang Z, Zheng M, Zoeckler ME, Vyas DM, Balasubramanian BN
Bioorg. Med. Chem. Lett. 2003-04-17 ;13( 8 ):1419-23.


Publications February 10, 2003

Sordaricin antifungal agents.

Quesnelle CA, Gill P, Dodier M, St Laurent D, Serrano-Wu M, Marinier A, Martel A, Mazzucco CE, Stickle TM, Barrett JF, Vyas DM, Balasubramanian BN
Bioorg. Med. Chem. Lett. 2003-02-10 ;13( 3 ):519-24.


Publications December 15, 2001

Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel).

Vivat-Hannah V, You D, Rizzo C, Daris JP, Lapointe P, Zusi FC, Marinier A, Lorenzi MV, Gottardis MM
Cancer Res. 2001-12-15 ;61( 24 ):8703-11.


Publications June 1, 2001

Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates.

Marinier A, Martel A, Bachand C, Plamondon S, Turmel B, Daris JP, Banville J, Lapointe P, Ouellet C, Dextraze P, Menard M, Wright JJ, Alford J, Lee D, Stanley P, Nair X, Todderud G, Tramposch KM
Bioorg. Med. Chem. 2001-06-01 ;9( 6 ):1395-427.


Publications February 6, 1998

Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes.

Ostrowski J, Roalsvig T, Hammer L, Marinier A, Starrett JE, Yu KL, Reczek PR
J. Biol. Chem. 1998-02-06 ;273( 6 ):3490-5.


Publications September 26, 1997

Sulfated galactocerebrosides as potential antiinflammatory agents.

Marinier A, Martel A, Banville J, Bachand C, Remillard R, Lapointe P, Turmel B, Menard M, Harte WE, Wright JJ, Todderud G, Tramposch KM, Bajorath J, Hollenbaugh D, Aruffo A
J. Med. Chem. 1997-09-26 ;40( 20 ):3234-47.


Publications September 1, 1997

BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions.

Todderud G, Nair X, Lee D, Alford J, Davern L, Stanley P, Bachand C, Lapointe P, Marinier A, Martel A, Menard M, Wright JJ, Bajorath J, Hollenbaugh D, Aruffo A, Tramposch KM
J. Pharmacol. Exp. Ther. 1997-09-01 ;282( 3 ):1298-304.


Publications September 1, 1994

HIV-1 protease inhibitors: ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs.

Marinier A, Toth MV, Houseman K, Mueller R, Marshall GR
Bioorg. Med. Chem. 1994-09-01 ;2( 9 ):919-25.


Publications September 1, 1992

Stereocontrolled chiral synthesis of a trans-anti-trans tricycle by a transannular Diels–Alder reaction

Marinier A, Deslongchamps P
1992-09-01 ;70( 9 ):2350-2364.


Publications February 1, 1989

Functionalized hydrocarbons with condensed ring skeletons. II. A tricyclo[8.4.0.02,7]tetradec-8-ene

Michel G, Boulay G, Marinier A
Acta Cryst. 1989-02-01 ;C45:325-327.


Publications November 20, 1988

Stereocontrolled synthesis of a trans-anti-trans tricycle via a transannular Diels-Alder strategy

Michel G, Boulay G, Marinier A
Tetrahedron Lett. 1988-11-20 ;29( 48 ):6215-6218.


Publications October 23, 1988

Synthesis and transannular Diels-Alder reaction of a trans-cis-cis 13-membered mycrocyclic trienone

Michel G, Boulay G, Marinier A
Tetrahedron Lett. 1988-10-23 ;28( 44 ):5253-5254.

Search filters

Search filters

Open accordion

Search filters

Close accordion
Active filters
Publications
Anne Marinier
Types of content
  • Publications (45)
Principal Investigators
  • Anne Marinier (45)
  • Benjamin Kwok (1)
  • Brian Wilhelm (1)
  • David Knapp (1)
  • Guy Sauvageau (16)
  • Marc Therrien (1)
  • Michael Tyers (5)
  • Michel Bouvier (4)
  • Philippe P. Roux (2)
  • Pierre Thibault (2)
  • Sylvain Meloche (2)
  • Sébastien Lemieux (12)
  • Trang Hoang (2)
  • Vincent Archambault (1)
Research topics
  • Cell Division & Migration (9)
  • Cell Signaling & Protein Dynamics (10)
  • Chemical & Structural Biology (45)
  • Computational Analysis & Modeling (45)
  • Genomics & Epigenetics (17)
  • Immunology & Hematopoiesis (16)
  • Targeted Therapies & Diagnostics (45)
Years
  • 2022 (4)
  • 2021 (3)
  • 2020 (2)
  • 2019 (8)
  • 2018 (1)
  • 2017 (3)
  • 2016 (3)
  • 2015 (2)
  • 2014 (3)
  • 2009 (1)
  • 2005 (1)
  • 2004 (2)
  • 2003 (2)
  • 2001 (2)
  • 1998 (1)
  • 1997 (2)
  • 1994 (1)
  • 1992 (1)
  • 1989 (1)
  • 1988 (2)
IRIC - Institute for Research in Immunology and Cancer

Primary navigation

  • About
  • Research
  • Training
  • Valorization
  • Careers
  • Support research
  • Directory
  • Press
  • Tools
  • Contact

IRIC | Université de Montréal
2950, Chemin de Polytechnique
Marcelle-Coutu Pavilion
Montréal, Québec  H3T 1J4
Canada

How to get to IRIC?

Phone
+1 514-343-7770
Fax
+1 514-343-7780

Social networks

Subscribe to the newsletter
Subscribe to the newsletter

Secondary navigation

  • Terms and conditions
  • Privacy policy

© 2003-2023 IRIC. All rights reserved.

Website by Principal