45 results
HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.
Moison C, Spinella JF, Chagraoui J, Lavallée VP, Lehnertz B, Thiollier C, Boivin I, Mayotte N, MacRae T, Marinier A, Hébert J, Sauvageau G
Blood Adv
2022-08-23
;6(
16
):4793-4806.
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier A
J Med Chem
2022-07-14
;65(
13
):8843-8854.
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du D, Yang JJ, Hoff FW, Kaminski M, Tomczak K, Eric Davis R, Herranz D, Ferrando A, Jabbour EJ, Emilia Di Francesco M, Teachey DT, Horton TM, Kornblau S, Rezvani K, Sauvageau G, Gagea M, Andreeff M, Takahashi K, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva M
Nat Commun
2022-05-19
;13(
1
):2801.
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.
Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau G
Blood Adv
2022-01-25
;6(
2
):509-514.
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.
St-Cyr D, Ceccarelli DF, Orlicky S, van der Sloot AM, Tang X, Kelso S, Moore S, James C, Posternak G, Coulombe-Huntington J, Bertomeu T, Marinier A, Sicheri F, Tyers M
Sci Adv
2021-10-29
;7(
44
):eabi5797.
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.
Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA
Nat Commun
2021-08-03
;12(
1
):4688.
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.
Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau G
Cell Stem Cell
2021-01-07
;28(
1
):48-62.e6.
Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
Toulouse JL, Shi G, Lemay-St-Denis C, Ebert MCCJC, Deon D, Gagnon M, Ruediger E, Saint-Jacques K, Forge D, Vanden Eynde JJ, Marinier A, Ji X, Pelletier JN
ACS Med Chem Lett
2020-11-12
;11(
11
):2261-2267.
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.
Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G
Lancet Haematol
2020-01-31
;7(
2
):e134-e145.
Genetic characterization of ABT-199 sensitivity in human AML.
Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D'Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G
Leukemia
2019-12-19
;34(
1
):63-74.
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.
Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A
J. Med. Chem.
2019-08-22
;62(
16
):7400-7416.
Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.
Labelle C, Marinier A, Lemieux S
Bioinformatics
2019-07-15
;35(
14
):i464-i473.
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G
Cancer Cell
2019-07-08
;36(
1
):84-99.e8.
Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN
ACS Omega
2019-06-30
;4(
6
):10056-10069.
Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.
Cyr P, Flynn-Robitaille J, Boissarie P, Marinier A
Org. Lett.
2019-04-05
;21(
7
):2265-2268.
Identification of Allosteric Inhibitors against Active Caspase-6.
Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC
Sci Rep
2019-04-02
;9(
1
):5504.
Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.
Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G
Blood Adv
2019-02-26
;3(
4
):552-563.
Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.
Lavallée VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GÉ, Hébert J, Sauvageau G
Leukemia
2018-06-01
;32(
6
):1349-1357.
Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.
Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau G
Clin. Cancer Res.
2017-11-15
;23(
22
):6969-6981.
A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.
Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G
Blood Cancer J
2017-02-17
;7(
2
):e529.
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.
Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J
Sci Transl Med
2017-01-04
;9(
371
):.
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.
Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok B, Roux PP, Hoang T
J. Clin. Invest.
2016-12-01
;126(
12
):4569-4584.
Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.
Normandin K, Lavallée JF, Futter M, Beautrait A, Duchaine J, Guiral S, Marinier A, Archambault V
Sci Rep
2016-11-22
;5:37581.
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.
Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G
Blood
2016-06-16
;127(
24
):3054-61.
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G
Nat. Genet.
2015-09-01
;47(
9
):1030-7.
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M
Nat. Struct. Mol. Biol.
2015-01-01
;22(
1
):37-43.
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.
Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp D, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G
Science
2014-09-19
;345(
6203
):1509-12.
Identification of small molecules that support human leukemia stem cell activity ex vivo.
Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G
Nat. Methods
2014-04-01
;11(
4
):436-42.
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F
Nat. Chem. Biol.
2014-02-01
;10(
2
):156-63.
Novel tricyclic inhibitors of IkappaB kinase.
Kempson J, Spergel SH, Guo J, Quesnelle C, Gill P, Belanger D, Dyckman AJ, Li T, Watterson SH, Langevine CM, Das J, Moquin RV, Furch JA, Marinier A, Dodier M, Martel A, Nirschl D, Van Kirk K, Burke JR, Pattoli MA, Gillooly K, McIntyre KW, Chen L, Yang Z, Marathe PH, Wang-Iverson D, Dodd JH, McKinnon M, Barrish JC, Pitts WJ
J. Med. Chem.
2009-04-09
;52(
7
):1994-2005.
Biaryl isoxazolinone antibacterial agents.
Quesnelle CA, Gill P, Roy S, Dodier M, Marinier A, Martel A, Snyder LB, D'Andrea SV, Bronson JJ, Frosco M, Beaulieu D, Warr GA, Denbleyker KL, Stickle TM, Yang H, Chaniewski SE, Ferraro CA, Taylor D, Russell JW, Santone KS, Clarke J, Drain RL, Knipe JO, Mosure K, Barrett JF
Bioorg. Med. Chem. Lett.
2005-06-02
;15(
11
):2728-33.
Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.
Snyder LB, Meng Z, Mate R, D'Andrea SV, Marinier A, Quesnelle CA, Gill P, DenBleyker KL, Fung-Tomc JC, Frosco M, Martel A, Barrett JF, Bronson JJ
Bioorg. Med. Chem. Lett.
2004-09-20
;14(
18
):4735-9.
Rational design of RAR-selective ligands revealed by RARbeta crystal stucture.
Germain P, Kammerer S, Pérez E, Peluso-Iltis C, Tortolani D, Zusi FC, Starrett J, Lapointe P, Daris JP, Marinier A, de Lera AR, Rochel N, Gronemeyer H
EMBO Rep.
2004-09-01
;5(
9
):877-82.
Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.
Serrano-Wu MH, Laurent DR, Carroll TM, Dodier M, Gao Q, Gill P, Quesnelle C, Marinier A, Mazzucco CE, Regueiro-Ren A, Stickle TM, Wu D, Yang H, Yang Z, Zheng M, Zoeckler ME, Vyas DM, Balasubramanian BN
Bioorg. Med. Chem. Lett.
2003-04-17
;13(
8
):1419-23.
Sordaricin antifungal agents.
Quesnelle CA, Gill P, Dodier M, St Laurent D, Serrano-Wu M, Marinier A, Martel A, Mazzucco CE, Stickle TM, Barrett JF, Vyas DM, Balasubramanian BN
Bioorg. Med. Chem. Lett.
2003-02-10
;13(
3
):519-24.
Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel).
Vivat-Hannah V, You D, Rizzo C, Daris JP, Lapointe P, Zusi FC, Marinier A, Lorenzi MV, Gottardis MM
Cancer Res.
2001-12-15
;61(
24
):8703-11.
Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates.
Marinier A, Martel A, Bachand C, Plamondon S, Turmel B, Daris JP, Banville J, Lapointe P, Ouellet C, Dextraze P, Menard M, Wright JJ, Alford J, Lee D, Stanley P, Nair X, Todderud G, Tramposch KM
Bioorg. Med. Chem.
2001-06-01
;9(
6
):1395-427.
Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes.
Ostrowski J, Roalsvig T, Hammer L, Marinier A, Starrett JE, Yu KL, Reczek PR
J. Biol. Chem.
1998-02-06
;273(
6
):3490-5.
Sulfated galactocerebrosides as potential antiinflammatory agents.
Marinier A, Martel A, Banville J, Bachand C, Remillard R, Lapointe P, Turmel B, Menard M, Harte WE, Wright JJ, Todderud G, Tramposch KM, Bajorath J, Hollenbaugh D, Aruffo A
J. Med. Chem.
1997-09-26
;40(
20
):3234-47.
BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions.
Todderud G, Nair X, Lee D, Alford J, Davern L, Stanley P, Bachand C, Lapointe P, Marinier A, Martel A, Menard M, Wright JJ, Bajorath J, Hollenbaugh D, Aruffo A, Tramposch KM
J. Pharmacol. Exp. Ther.
1997-09-01
;282(
3
):1298-304.
HIV-1 protease inhibitors: ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs.
Marinier A, Toth MV, Houseman K, Mueller R, Marshall GR
Bioorg. Med. Chem.
1994-09-01
;2(
9
):919-25.
Stereocontrolled chiral synthesis of a trans-anti-trans tricycle by a transannular Diels–Alder reaction
Marinier A, Deslongchamps P
1992-09-01
;70(
9
):2350-2364.
Functionalized hydrocarbons with condensed ring skeletons. II. A tricyclo[8.4.0.02,7]tetradec-8-ene
Michel G, Boulay G, Marinier A
Acta Cryst.
1989-02-01
;C45:325-327.
Stereocontrolled synthesis of a trans-anti-trans tricycle via a transannular Diels-Alder strategy
Michel G, Boulay G, Marinier A
Tetrahedron Lett.
1988-11-20
;29(
48
):6215-6218.
Synthesis and transannular Diels-Alder reaction of a trans-cis-cis 13-membered mycrocyclic trienone
Michel G, Boulay G, Marinier A
Tetrahedron Lett.
1988-10-23
;28(
44
):5253-5254.