23 results
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.
Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard J, Blobel GA, Garcia BA, Bernt KM
Mol Cell
2021-06-03
;81(
11
):2332-2348.e9.
Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.
Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Theroux JF, Jefri M, Tanti A, Wu H, Kolobova I, Silviera H, Manzano-Vargas K, Ehresmann S, Hamdan FF, Hettige N, Zhang X, Antonyan L, Nassif C, Ghaloul-Gonzalez L, Sebastian J, Vockley J, Begtrup AG, Wentzensen IM, Crunk A, Nicholls RD, Herman KC, Deignan JL, Al-Hertani W, Efthymiou S, Salpietro V, Miyake N, Makita Y, Matsumoto N, Østern R, Houge G, Hafström M, Fassi E, Houlden H, Klein Wassink-Ruiter JS, Nelson D, Goldstein A, Dabir T, van Gils J, Bourgeron T, Delorme R, Cooper GM, Martinez JE, Finnila CR, Carmant L, Lortie A, Oegema R, van Gassen K, Mehta SG, Huhle D, Abou Jamra R, Martin S, Brunner HG, Lindhout D, Au M, Graham JM, Coubes C, Turecki G, Gravel S, Mechawar N, Rossignol E, Michaud JL, Lessard J, Ernst C, Campeau PM
Am. J. Hum. Genet.
2019-05-02
;104(
5
):815-834.
SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism.
Priam P, Krasteva V, Rousseau P, D'Angelo G, Gaboury L, Sauvageau G, Lessard J
Nat. Genet.
2017-05-01
;49(
5
):753-764.
The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance.
Krasteva V, Crabtree GR, Lessard J
Exp. Hematol.
2017-04-01
;48:58-71.e15.
Myelopoiesis.
Lessard J, Hoang T
Encyclopedia of Immunobiology
2016-04-27
;1:26-37.
Bloody signals: From birth to disease and death.
Trompouki E, King KY, Will B, Lessard J, Flores-Figueroa E, Kokkaliaris KD, Bowman T
Exp. Hematol.
2014-12-01
;42(
12
):989-94.
An exchange of alternative ATPases within BAF complexes accompanies the transition from hemopoietic stem cell quiescence to proliferation.
Buscarlet M, Krasteva V, Ho L, Simon C, Hebert J, Wilhelm B, Crabtree G, Sauvageau G, Thibault P, Lessard J
Exp. Hematol.
2014-08-01
;42(
8 Suppl
):S4.
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.
Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard J
Blood
2014-03-13
;123(
11
):1720-8.
The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function.
Krasteva V, Buscarlet M, Diaz-Tellez A, Bernard MA, Crabtree GR, Lessard J
Blood
2012-12-06
;120(
24
):4720-32.
Chromatin regulatory mechanisms in pluripotency.
Lessard J, Crabtree GR
Annu. Rev. Cell Dev. Biol.
2010-11-10
;26:503-32.
A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.
Krosl J, Mamo A, Chagraoui J, Wilhelm B, Girard S, Louis I, Lessard J, Perreault C, Sauvageau G
Blood
2010-09-09
;116(
10
):1678-84.
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.
Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI, Ranish J, Crabtree GR
Proc. Natl. Acad. Sci. U.S.A.
2009-03-31
;106(
13
):5181-6.
Understanding the words of chromatin regulation.
Wu JI, Lessard J, Crabtree GR
Cell
2009-01-23
;136(
2
):200-6.
Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia.
Sauvageau G, Miller M, Lemieux S, Lessard J, Hébert J, Sauvageau G
Blood
2008-01-15
;111(
2
):790-9.
Regulation of dendritic development by neuron-specific chromatin remodeling complexes.
Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR
Neuron
2007-10-04
;56(
1
):94-108.
An essential switch in subunit composition of a chromatin remodeling complex during neural development.
Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR
Neuron
2007-07-19
;55(
2
):201-15.
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau G, Meloche S, Sauvageau G
Genes Dev.
2006-08-01
;20(
15
):2110-20.
Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells?
Faubert A, Lessard J, Sauvageau G
Oncogene
2004-09-20
;23(
43
):7247-55.
Genetic programs regulating HSC specification, maintenance and expansion.
Lessard J, Faubert A, Sauvageau G
Oncogene
2004-09-20
;23(
43
):7199-209.
Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis.
Lessard J, Sauvageau G
Exp. Hematol.
2003-07-01
;31(
7
):567-85.
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard J, Sauvageau G
Nature
2003-05-15
;423(
6937
):255-60.
Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.
Lessard J, Schumacher A, Thorsteinsdottir U, van Lohuizen M, Magnuson T, Sauvageau G
Genes Dev.
1999-10-15
;13(
20
):2691-703.
Stage-specific expression of polycomb group genes in human bone marrow cells.
Lessard J, Baban S, Sauvageau G
Blood
1998-02-15
;91(
4
):1216-24.