57 results
Structural keys unlock RAS-MAPK cellular signalling pathway.
Lavoie H, Therrien M
Nature
2022-09-01
;609(
7926
):248-249.
A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.
Gavory G, Baril C, Laberge G, Bidla G, Koonpaew S, Sonea T, Sauvageau G, Therrien M
PLoS Genet
2021-08-12
;17(
8
):e1009730.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F
Nat Chem Biol
2020-11-01
;16(
11
):1170-1178.
ERK signalling: a master regulator of cell behaviour, life and fate.
Lavoie H, Gagnon J, Therrien M
Nat Rev Mol Cell Biol
2020-10-01
;21(
10
):607-632.
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.
Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB
Nat Commun
2018-10-22
;9(
1
):4385.
Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.
Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F
Am. J. Med. Genet. A
2018-10-10
;e40632.
MEK drives BRAF activation through allosteric control of KSR proteins.
Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M
Nature
2018-02-22
;554(
7693
):549-553.
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.
Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien M
Nat Commun
2017-10-31
;8(
1
):1211.
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.
Kubiniok P, Lavoie H, Therrien M, Thibault P
Mol. Cell Proteomics
2017-04-01
;16(
4
):663-679.
How Genetics Has Helped Piece Together the MAPK Signaling Pathway.
Ashton-Beaucage D, Therrien M
Methods Mol. Biol.
2017-01-01
;1487:1-21.
Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.
Baril C, Gavory G, Bidla G, Knævelsrud H, Sauvageau G, Therrien M
Dev. Biol.
2017-01-01
;421(
1
):16-26.
Inhibition of RAS function through targeting an allosteric regulatory site.
Smith M, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP
Nat. Chem. Biol.
2017-01-01
;13(
1
):62-68.
The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.
Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien M
PLoS Biol.
2016-08-01
;14(
8
):e1002539.
Regulation of RAF protein kinases in ERK signalling.
Lavoie H, Therrien M
Nat. Rev. Mol. Cell Biol.
2015-04-23
;16(
5
):281-98.
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M
Nat. Struct. Mol. Biol.
2015-01-01
;22(
1
):37-43.
Dimerization-induced allostery in protein kinase regulation.
Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F
Trends Biochem. Sci.
2014-10-01
;39(
10
):475-486.
Apical Accumulation of the Sevenless Receptor Tyrosine Kinase During Drosophila Eye Development Is Promoted by the Small GTPase Rap1.
Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien M
Genetics
2014-06-03
;197(
4
):1237-1250.
Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.
Mashtalir N, Daou S, Barbour H, Sen NN, Gagnon J, Hammond-Martel I, Dar HH, Therrien M, Affar el B
Mol. Cell
2014-05-08
;54(
3
):392-406.
A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila.
Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M
PLoS Biol.
2014-03-01
;12(
3
):e1001809.
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M
Nat. Chem. Biol.
2013-07-01
;9(
7
):428-36.
Cancer: A drug-resistant duo.
Lavoie H, Therrien M
Nature
2011-12-15
;480(
7377
):329-30.
Mechanistic principles of RAF kinase signaling.
Udell CM, Rajakulendran T, Sicheri F, Therrien M
Cell. Mol. Life Sci.
2011-02-01
;68(
4
):553-65.
The exon junction complex: a splicing factor for long intron containing transcripts?
Ashton-Beaucage D, Therrien M
Fly (Austin)
2011-01-01
;5(
3
):224-33.
A comprehensive map of the mTOR signaling network.
Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H
Mol. Syst. Biol.
2010-12-21
;6:453.
[The greater RTK/RAS/ERK signalling pathway: how genetics has helped piece together a signalling network].
Ashton-Beaucage D, Therrien M
Med Sci (Paris)
2010-12-01
;26(
12
):1067-73.
The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.
Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M
Cell
2010-10-15
;143(
2
):251-62.
[It takes two RAFs to tango].
Lavoie H, Therrien M
Med Sci (Paris)
2010-05-01
;26(
5
):459-60.
A dimerization-dependent mechanism drives RAF catalytic activation.
Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M
Nature
2009-09-24
;461(
7263
):542-5.
The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.
Baril C, Sahmi M, Ashton-Beaucage D, Stronach B, Therrien M
Genetics
2009-02-01
;181(
2
):567-79.
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.
Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F
Proc. Natl. Acad. Sci. U.S.A.
2008-02-26
;105(
8
):2836-41.
KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
Clapéron A, Therrien M
Oncogene
2007-05-14
;26(
22
):3143-58.
Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila.
Baril C, Therrien M
Dev. Biol.
2006-06-01
;294(
1
):232-45.
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.
Douziech M, Sahmi M, Laberge G, Therrien M
Genes Dev.
2006-04-01
;20(
7
):807-19.
Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.
Laberge G, Douziech M, Therrien M
EMBO J.
2005-02-09
;24(
3
):487-98.
Bimodal regulation of RAF by CNK in Drosophila.
Douziech M, Roy F, Laberge G, Lefrançois M, Armengod AV, Therrien M
EMBO J.
2003-10-01
;22(
19
):5068-78.
MAP kinase module: the Ksr connection.
Roy F, Therrien M
Curr. Biol.
2002-04-30
;12(
9
):R325-7.
KSR is a scaffold required for activation of the ERK/MAPK module.
Roy F, Laberge G, Douziech M, Ferland-McCollough D, Therrien M
Genes Dev.
2002-02-15
;16(
4
):427-38.
A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila.
Therrien M, Morrison DK, Wong AM, Rubin GM
Genetics
2000-11-01
;156(
3
):1231-42.
Functional analysis of CNK in RAS signaling.
Therrien M, Wong AM, Kwan E, Rubin GM
Proc. Natl. Acad. Sci. U.S.A.
1999-11-09
;96(
23
):13259-63.
Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.
Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK
Mol. Cell. Biol.
1999-01-01
;19(
1
):229-40.
CNK, a RAF-binding multidomain protein required for RAS signaling.
Therrien M, Wong AM, Rubin GM
Cell
1998-10-30
;95(
3
):343-53.
KSR stimulates Raf-1 activity in a kinase-independent manner.
Michaud NR, Therrien M, Cacace A, Edsall LC, Spiegel S, Rubin GM, Morrison DK
Proc. Natl. Acad. Sci. U.S.A.
1997-11-25
;94(
24
):12792-6.
CP-225,917 and CP-263,114, novel Ras farnesylation inhibitors from an unidentified fungus. I. Taxonomy, fermentation, isolation, and biochemical properties.
Dabrah TT, Harwood HJ, Huang LH, Jankovich ND, Kaneko T, Li JC, Lindsey S, Moshier PM, Subashi TA, Therrien M, Watts PC
J. Antibiot.
1997-01-01
;50(
1
):1-7.
Signal transduction downstream from Ras in Drosophila.
Rubin GM, Chang HC, Karim F, Laverty T, Michaud NR, Morrison DK, Rebay I, Tang A, Therrien M, Wassarman DA
Cold Spring Harb. Symp. Quant. Biol.
1997-01-01
;62:347-52.
KSR modulates signal propagation within the MAPK cascade.
Therrien M, Michaud NR, Rubin GM, Morrison DK
Genes Dev.
1996-11-01
;10(
21
):2684-95.
Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.
Lamonerie T, Tremblay JJ, Lanctôt C, Therrien M, Gauthier Y, Drouin J
Genes Dev.
1996-05-15
;10(
10
):1284-95.
A screen for genes that function downstream of Ras1 during Drosophila eye development.
Karim FD, Chang HC, Therrien M, Wassarman DA, Laverty T, Rubin GM
Genetics
1996-05-01
;143(
1
):315-29.
Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.
Wassarman DA, Solomon NM, Chang HC, Karim FD, Therrien M, Rubin GM
Genes Dev.
1996-02-01
;10(
3
):272-8.
KSR, a novel protein kinase required for RAS signal transduction.
Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM
Cell
1995-12-15
;83(
6
):879-88.
phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila.
Chang HC, Solomon NM, Wassarman DA, Karim FD, Therrien M, Rubin GM, Wolff T
Cell
1995-02-10
;80(
3
):463-72.