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53 results

Publications — IRIC October 22, 2018

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.

Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB
Nat Commun 2018-10-22 ;9( 1 ):4385.

Publications — IRIC October 10, 2018

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.

Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F
Am. J. Med. Genet. A 2018-10-10 ;e40632.

Publications — IRIC February 22, 2018

MEK drives BRAF activation through allosteric control of KSR proteins.

Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M
Nature 2018-02-22 ;554( 7693 ):549-553.

Publications — IRIC October 31, 2017

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.

Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien M
Nat Commun 2017-10-31 ;8( 1 ):1211.

Publications — IRIC April 1, 2017

Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.

Kubiniok P, Lavoie H, Therrien M, Thibault P
Mol. Cell Proteomics 2017-04-01 ;16( 4 ):663-679.

Publications — IRIC January 1, 2017

How Genetics Has Helped Piece Together the MAPK Signaling Pathway.

Ashton-Beaucage D, Therrien M
Methods Mol. Biol. 2017-01-01 ;1487:1-21.

Publications — IRIC January 1, 2017

Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.

Baril C, Gavory G, Bidla G, Knævelsrud H, Sauvageau G, Therrien M
Dev. Biol. 2017-01-01 ;421( 1 ):16-26.

Publications — IRIC January 1, 2017

Inhibition of RAS function through targeting an allosteric regulatory site.

Smith M, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP
Nat. Chem. Biol. 2017-01-01 ;13( 1 ):62-68.

Publications — IRIC August 1, 2016

The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.

Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien M
PLoS Biol. 2016-08-01 ;14( 8 ):e1002539.

Publications — IRIC April 23, 2015

Regulation of RAF protein kinases in ERK signalling.

Lavoie H, Therrien M
Nat. Rev. Mol. Cell Biol. 2015-04-23 ;16( 5 ):281-98.

Publications — IRIC January 1, 2015

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.

Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M
Nat. Struct. Mol. Biol. 2015-01-01 ;22( 1 ):37-43.

Publications — IRIC October 1, 2014

Dimerization-induced allostery in protein kinase regulation.

Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F
Trends Biochem. Sci. 2014-10-01 ;39( 10 ):475-486.

Publications — IRIC June 3, 2014

Apical Accumulation of the Sevenless Receptor Tyrosine Kinase During Drosophila Eye Development Is Promoted by the Small GTPase Rap1.

Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien M
Genetics 2014-06-03 ;197( 4 ):1237-1250.

Publications — IRIC May 8, 2014

Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.

Mashtalir N, Daou S, Barbour H, Sen NN, Gagnon J, Hammond-Martel I, Dar HH, Therrien M, Affar el B
Mol. Cell 2014-05-08 ;54( 3 ):392-406.

Publications — IRIC March 1, 2014

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila.

Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M
PLoS Biol. 2014-03-01 ;12( 3 ):e1001809.

Publications — IRIC July 1, 2013

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.

Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M
Nat. Chem. Biol. 2013-07-01 ;9( 7 ):428-36.

Publications — IRIC December 15, 2011

Cancer: A drug-resistant duo.

Lavoie H, Therrien M
Nature 2011-12-15 ;480( 7377 ):329-30.

Publications — IRIC February 1, 2011

Mechanistic principles of RAF kinase signaling.

Udell CM, Rajakulendran T, Sicheri F, Therrien M
Cell. Mol. Life Sci. 2011-02-01 ;68( 4 ):553-65.

Publications — IRIC January 1, 2011

The exon junction complex: a splicing factor for long intron containing transcripts?

Ashton-Beaucage D, Therrien M
Fly (Austin) 2011-01-01 ;5( 3 ):224-33.

Publications — IRIC December 21, 2010

A comprehensive map of the mTOR signaling network.

Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H
Mol. Syst. Biol. 2010-12-21 ;6:453.

Publications — IRIC December 1, 2010

[The greater RTK/RAS/ERK signalling pathway: how genetics has helped piece together a signalling network].

Ashton-Beaucage D, Therrien M
Med Sci (Paris) 2010-12-01 ;26( 12 ):1067-73.

Publications — IRIC October 15, 2010

The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.

Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M
Cell 2010-10-15 ;143( 2 ):251-62.

Publications — IRIC May 1, 2010

[It takes two RAFs to tango].

Lavoie H, Therrien M
Med Sci (Paris) 2010-05-01 ;26( 5 ):459-60.

Publications — IRIC September 24, 2009

A dimerization-dependent mechanism drives RAF catalytic activation.

Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M
Nature 2009-09-24 ;461( 7263 ):542-5.

Publications — IRIC February 1, 2009

The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.

Baril C, Sahmi M, Ashton-Beaucage D, Stronach B, Therrien M
Genetics 2009-02-01 ;181( 2 ):567-79.

Publications — IRIC February 26, 2008

CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.

Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F
Proc. Natl. Acad. Sci. U.S.A. 2008-02-26 ;105( 8 ):2836-41.

Publications — IRIC May 14, 2007

KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.

Clapéron A, Therrien M
Oncogene 2007-05-14 ;26( 22 ):3143-58.

Publications — IRIC June 1, 2006

Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila.

Baril C, Therrien M
Dev. Biol. 2006-06-01 ;294( 1 ):232-45.

Publications — IRIC April 1, 2006

A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.

Douziech M, Sahmi M, Laberge G, Therrien M
Genes Dev. 2006-04-01 ;20( 7 ):807-19.

Publications — IRIC February 9, 2005

Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism.

Laberge G, Douziech M, Therrien M
EMBO J. 2005-02-09 ;24( 3 ):487-98.

Publications — IRIC October 1, 2003

Bimodal regulation of RAF by CNK in Drosophila.

Douziech M, Roy F, Laberge G, Lefrançois M, Armengod AV, Therrien M
EMBO J. 2003-10-01 ;22( 19 ):5068-78.

Publications April 30, 2002

MAP kinase module: the Ksr connection.

Roy F, Therrien M
Curr. Biol. 2002-04-30 ;12( 9 ):R325-7.

Publications February 15, 2002

KSR is a scaffold required for activation of the ERK/MAPK module.

Roy F, Laberge G, Douziech M, Ferland-McCollough D, Therrien M
Genes Dev. 2002-02-15 ;16( 4 ):427-38.

Publications November 1, 2000

A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila.

Therrien M, Morrison DK, Wong AM, Rubin GM
Genetics 2000-11-01 ;156( 3 ):1231-42.

Publications November 9, 1999

Functional analysis of CNK in RAS signaling.

Therrien M, Wong AM, Kwan E, Rubin GM
Proc. Natl. Acad. Sci. U.S.A. 1999-11-09 ;96( 23 ):13259-63.

Publications January 1, 1999

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.

Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK
Mol. Cell. Biol. 1999-01-01 ;19( 1 ):229-40.

Publications October 30, 1998

CNK, a RAF-binding multidomain protein required for RAS signaling.

Therrien M, Wong AM, Rubin GM
Cell 1998-10-30 ;95( 3 ):343-53.

Publications November 25, 1997

KSR stimulates Raf-1 activity in a kinase-independent manner.

Michaud NR, Therrien M, Cacace A, Edsall LC, Spiegel S, Rubin GM, Morrison DK
Proc. Natl. Acad. Sci. U.S.A. 1997-11-25 ;94( 24 ):12792-6.

Publications January 1, 1997

CP-225,917 and CP-263,114, novel Ras farnesylation inhibitors from an unidentified fungus. I. Taxonomy, fermentation, isolation, and biochemical properties.

Dabrah TT, Harwood HJ, Huang LH, Jankovich ND, Kaneko T, Li JC, Lindsey S, Moshier PM, Subashi TA, Therrien M, Watts PC
J. Antibiot. 1997-01-01 ;50( 1 ):1-7.

Publications January 1, 1997

Signal transduction downstream from Ras in Drosophila.

Rubin GM, Chang HC, Karim F, Laverty T, Michaud NR, Morrison DK, Rebay I, Tang A, Therrien M, Wassarman DA
Cold Spring Harb. Symp. Quant. Biol. 1997-01-01 ;62:347-52.

Publications November 1, 1996

KSR modulates signal propagation within the MAPK cascade.

Therrien M, Michaud NR, Rubin GM, Morrison DK
Genes Dev. 1996-11-01 ;10( 21 ):2684-95.

Publications May 15, 1996

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.

Lamonerie T, Tremblay JJ, Lanctôt C, Therrien M, Gauthier Y, Drouin J
Genes Dev. 1996-05-15 ;10( 10 ):1284-95.

Publications May 1, 1996

A screen for genes that function downstream of Ras1 during Drosophila eye development.

Karim FD, Chang HC, Therrien M, Wassarman DA, Laverty T, Rubin GM
Genetics 1996-05-01 ;143( 1 ):315-29.

Publications February 1, 1996

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

Wassarman DA, Solomon NM, Chang HC, Karim FD, Therrien M, Rubin GM
Genes Dev. 1996-02-01 ;10( 3 ):272-8.

Publications December 15, 1995

KSR, a novel protein kinase required for RAS signal transduction.

Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM
Cell 1995-12-15 ;83( 6 ):879-88.

Publications February 10, 1995

phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila.

Chang HC, Solomon NM, Wassarman DA, Karim FD, Therrien M, Rubin GM, Wolff T
Cell 1995-02-10 ;80( 3 ):463-72.

Publications February 1, 1995

The Ras signaling pathway in Drosophila.

Wassarman DA, Therrien M, Rubin GM
Curr. Opin. Genet. Dev. 1995-02-01 ;5( 1 ):44-50.

Publications August 31, 1994

Cloning and functional expression of the bovine natriuretic peptide receptor-B (natriuretic factor R1c subtype.

Fenrick R, Babinski K, McNicoll N, Therrien M, Drouin J, De Léan A
Mol. Cell. Biochem. 1994-08-31 ;137( 2 ):173-82.

Publications January 1, 1994

Ras signal transduction pathway in Drosophila eye development.

Chang HC, Karim FD, O'Neill EM, Rebay I, Solomon NM, Therrien M, Wassarman DA, Wolff T, Rubin GM
Cold Spring Harb. Symp. Quant. Biol. 1994-01-01 ;59:147-53.

Publications May 31, 1993

Molecular determinants for cell specificity and glucocorticoid repression of the proopiomelanocortin gene.

Therrien M, Drouin J
Ann. N. Y. Acad. Sci. 1993-05-31 ;680:663-71.

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Marc Therrien
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  • Publications (53)
Principal Investigators
  • Anne Marinier (1)
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  • Marc Therrien (53)
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  • Michael Tyers (1)
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  • Philippe P. Roux (1)
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