Program structure

 

The fast-track (1 year) M.Sc. program in Molecular Biology, Systems Biology option, consists of core curriculum courses (Block A), elective courses (Blocks B, C and D), and two laboratory rotations (Block E):

Click on a course title to see its description.

Block A : Core curriculum courses (12 credits)

credits
BIM6035 - Research Seminars I

Course coordinator : Martine Raymond
Terms: Fall, Winter

During the BIM6035 course, students present the two research projects they have undertaken during their laboratory rotations (BIM6076A and BIM6076B). Lasting 20 minutes, this seminar is organized as follows: an introduction to the topic of research including a review of literature, a description of the research projects objectives, a presentation of the results, a discussion and conclusion on the results and a description of upcoming experiments. This course aims to teach students how to summarize their research, to present scientific results orally and to discuss their research project.

credits
BIM6064A - Cellular and Molecular Biology of Cancer

Course coordinators : Damien D’Amours, Sylvie Mader
Term: Summer

The BIM6064A course offers lectures in the fields of cellular and molecular biology of cancer, addressing in particular the mechanisms of gene expression and cell cycle control, their regulation by signalling pathways and deregulation in cancer. This course includes the following presentations:

  • Transcriptional regulation of gene expression and cancer (by Sylvie Mader)
  • Epigenetic regulation of gene expression and cancer (by Julie Lessard)
  • Regulation of gene expression at the post-transcriptional level (by Katherine Borden)
  • DNA replication and chromosomal integrity (by Lea Harrington)
  • Introduction to cell cycle (by Damien D’Amours)
  • Biology of miRNAs (by Gerardo Ferbeyre)
  • Biophysical analysis of the structure of macromolecules (by Katherine Borden)
  • Signalling pathways (by Gregory Emery)
  • Signalling and cell cycle progression (by Sylvain Meloche)
  • Molecular genetics of cancer (by Trang Hoang)
credits
BIM6064C - Approaches in Systems Biology

Course coordinators: Sébastien Carréno, Philippe Roux, Sylvie Mader
Term: Summer

The BIM6064C course offers lectures on state-of-the-art systems biology approaches for the analysis of cell signalling and molecular genetics and their contribution to research in cancer biology and molecular genetics. This course includes the following presentations:

  • How to write a scholarship application (by Sylvie Mader)
  • RNAi screens in Drosophila melanogaster (by Sébastien Carréno)
  • Proteomics (by Pierre Thibault)
  • The phosphoproteome (by Philippe Roux)
  • Genetic screens (by Vincent Archambault)
  • Network modeling and analysis (by Stephen Michnick)
  • Synthetic biology (by Mike Tyers)
credits
BIM6065A - Practice in molecular biology

Course coordinators: Alain Verreault, Sylvie Mader
Term: Summer

This course emphasizes hands-on training in molecular biology (e.g. site-directed mutagenesis, DNA sequencing and construction of expression vectors by conventional molecular cloning and by in vitro recombination). It familiarizes students with simple, rapid and efficient recombinant DNA techniques, This course includes bench work and use of equipment at IRIC genomics core facility, formal presentations, group discussions and written assignments.

credits
BIM6065C - Bioinformatics Analysis

Course coordinator: François Major, Sébastien Lemieux, Sylvie Mader
Term: Summer

Through lectures and computer lab sessions, this course aims at familiarizing students with 1) databases, 2) network analysis, and 3) modeling of the structure of macromolecule. It includes formal presentations and leading to a variety of assignments.

credits
BIM6065E - Biochemistry of proteins

Course coordinators: Benjamin Kwok, Sylvie Mader
Term: Summer

This course offers laboratory training in protein biochemistry techniques and follows the BIM6065A course. It familiarizes students with techniques to 1) express and purify proteins (e.g. FPLC chromatography), and 2) study the chemical and biophysical properties of proteins (e.g. mass spectrometry, circular dichroism and ultracentrifugation). This course includes laboratory training, experiments making use of IRIC proteomics and biophysics core facilities, formal presentations, group discussions and written assignments.

credits
BIM6070 - Professional Practice of Research

Course coordinators: Jennifer Estall
Term: Fall

BIM6070 introduces students to the scientific method in research and to the experimental approach. Furthermore, this course initiates them to the scientific critical review, to the writing of a scientific article, to the writing of a research project and to the preparation of a grant proposal. Also, this course allows a space for ethical reflection where students are asked to discuss the main ethical questions raised by biomedical research. Finally, invited speakers present to students some career possibilities in the field of biomedical research.

The course aims to allow students to acquire the necessary competencies for the practice of biomedical research: 1) design a research plan based on the scientific method, 2) exercise their critical thinking, 3) write a scientific article, 4) write a research project, 5) become acquainted with the rules of conduct, duties and obligations of students and professionals in the field of scientific research, 6) learn about various career possibilities in the field of biomedical research.

credits
MMD 6005R Ethics and health sciences research

DESCRIPTION

Biomedical developments and research; major regulatory texts; relation between ethics and technology; ethical assessment of a project; researcher scientific integrity.

Block B : One of the two following elective courses (for a total of 2 credits)

credits
BIM6064B - Molecular Genetics of Eukaryotes

Course coordinators: Jean-Claude Labbé, Sylvie Mader
Term: Summer

The BIM6064B course offers lectures on the molecular genetics of eukaryotes and the use of biological models for the study of cell signalling and cancer. It aims at highlighting the impact of genetic research using biological models on our understanding of cancer. This course includes the following presentations:

  • Thinking like a geneticist  (by Alain Verreault)
  • Caenorhabditis elegans: signalling in multicellular organisms (by Jean-Claude Labbé)
  • Xenopus laevis as a model organism (by Benjamin Kwok)
  • The mouse: analyzing the function of genes in mammals (by Benjamin Turgeon)
  • Drosophila melanogaster: genetics of higher eukaryotes (by Marc Therrien)
  • Eukaryotic cells in culture: genetics of cancer (by Guy Sauvageau)
  • Yeasts: genetics of unicellular eukaryotes (by Damien D’Amours)
  • Fundamentals in light and fluorescence microscopy  (by Étienne Gagnon)
credits
BIM6064D - Immuno-oncology: From the Laboratory to the Clinic

Course coordinator: Claude Perreault, Sylvie Mader
Term: Summer

The BIM6064D course offers lectures on therapeutic targeting, drug development, translational and clinical research in leukemia and breast cancer, the use of stem cells in cancer therapy, and immunotherapy. It reviews basic concepts in immunology and oncology and presents examples of drug development and translational cancer research. In addition to the visit of IRIC histology and high-throughput screening core facilities, this course includes the following lectures:

  • Malignant hemopathies (by Jean Roy)
  • Chromosomal aberrations / Laboratory tests in clinical hematology and cancer (by Josée Hébert)
  • Stem cells and cancer treatment (by Guy Sauvageau)
  • How to set up clinical trials in cell therapy (by Denis-Claude Roy)
  • Drug development and high-throughput screening (by Benjamin Kwok)
  • Pharmacological modulation of cell signalling: membrane receptors (by Michel Bouvier)
  • Pharmacological modulation of cell signalling: nuclear receptors and cancer (by Sylvie Mader)
  • Breast cancer, clinical tests and histology (by Louis Gaboury)
  • General concepts of immunology and antigen presentation (by Claude Perreault)
  • Function of T-cell and cancer immunotherapy (by Etienne Gagnon)
  • Innate immunity (by John White)
  • Testimony from a cancer survivor (speaker to be announced)

Block C : One of the two following elective courses (for a total of 1 credit)

credits
BIM6065B - Genetic Models of Cancer

Course coordinator: Trang Hoang, Sylvie Mader
Term: Summer

This course offers laboratory training on cell analysis by microscopy and flow cytometry using various models (e.g. transgenic mice, Caenorhabditis elegans, Drosophila melanogaster). It aims at familiarizing students with techniques for 1) dissection and cell analysis using model organisms, 2) mouse transgenesis, 3) flow cytometry and data analysis, and 4) confocal microscopy. This course includes visits and/or use of several IRIC core facilities (i.e. Flow cytometry, Bioimaging, Transgenesis), lectures (e.g. on bioimaging tools) and demonstrations leading to various assignments.

credits
BIM6065D - Functional Genomics

Course coordinator: Brian Wilhelm, Sébastien Lemieux
Term: Summer

This module offers training in functional genomics, with a focus on the analysis of genomes and gene expression patterns by DNA microarray analysis and high-throughput sequencing. It provides hands-on training in large scale chromatin immunoprecipitation, DNA microarray hybridization and data analysis. This module includes lectures and laboratory training leading to various assignments.

Block D : One of the two following elective courses (for a total of 2 credits)

credits
Any other course considered relevant to the student's training.

Any other course considered relevant to the student’s training.

For a list a courses available, «Click here».

credits
BIM6021 - Topics in molecular oncology

Course coordinators: Damien D’Amours, Benjamin Kwok
Term: Winter

Through a series of weekly lectures given by internationally renowned researchers from various fields of biomedical research (part of IRIC Distinguished Scientist Lecture Series), this course aims to 1) expose students to different techniques and experimental systems in molecular, cellular and structural biology, 2 ) improve their ability to track and summarize results presented in scientific articles and seminars, 3) exercise their critical judgment, 4) improve their scientific communication skills.

Block E : Research activities (28 credits)

credits
BIM6076A - Laboratory Rotation I

Course coordinator: Martine Raymond
Terms: Fall, Winter

The BIM6076A and BIM6076B courses correspond to laboratory rotations taking place in two separate research teams. During these rotations, lasting four months each, you will be working on research projects under the supervision of a principal investigator. At the end of each rotation, you will be writing an internship report in the form of a scientific manuscript.

credits
BIM6076B - Laboratory Rotation II

Course coordinator: Martine Raymond
Terms: Fall, Winter

The BIM6076A and BIM6076B courses correspond to laboratory rotations taking place in two separate research teams. During these rotations, lasting four months each, you will be working on research projects under the supervision of a principal investigator. At the end of each rotation, you will be writing an internship report in the form of a scientific manuscript.

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