Stagiaire postdoctoral, Biochimie, biophysique et découverte de médicaments

Veuillez soumettre votre candidature d’ici le 31 décembre 2019.

Seuls les candidats retenus seront contactés.

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Titre d’emploi

Stagiaire postdoctoral, Biochimie, biophysique et découverte de médicaments

Unité de recherche

Unité de recherche en structure et fonction du noyau cellulaire

Supervision

Katherine Borden

Description uniquement disponible en anglais pour le moment.

Mandate Description

The Institute for Research in Immunology and Cancer (IRIC) at the University of Montréal has an immediate opening for a funded postdoctoral fellowship in the field of biophysics/NMR and drug discovery.

The project will use a variety of techniques to develop specific inhibitors for the human UGT family of enzymes which have recently been implicated in a novel multi-drug resistance pathway of numerous FDA approved drugs (Nature. 2014;511(7507):90-3, ACS Chem Biol. 2019, 14(3):348-355).

Under the supervision of Dr. Borden, the recruited fellow will build on our previous work in identifying weak, specific inhibitors for UGT1A4 using a combination of NMR fragment screening and biological assays (J Mol Biol. 2019; 431(2):258-272) with an aim to achieve one or more of the following:

  • improve efficacy of candidate molecules whilst retaining specificity using medicinal chemistry SAR combined with NMR, Xray, and biochemical screens
  • perform NMR-based fragment screens against other human UGT enzyme families to identify mechanisms of specificity and recognition between different UGT families
  • generate 3D high-resolution structures of fragment bound protein complexes.

The successful candidate will have an interest in drug design, with expertise in characterizing protein-ligand interactions or SAR via one or more of the following techniques; NMR, ITC, X-ray crystallography, medicinal chemistry, and biochemical assays.

Research will be conducted at state-of-the-art facilities at the Institute for Research in Immunology and Cancer on the campus (IRIC) of Université of Montreal in Dr. Katherine Borden’s lab. (www.iric.ca).

More information about Dr. Borden’s research can be found here.

Job requirements

Education & Experience:

  • Ph.D. in a related field (i.e. protein biochemistry, biophysics, molecular biology, chemistry)
  • Substantial experience in protein structure investigations, including protein/small molecule interactions. Experience in fragment-based screening and/or drug design is preferred but not required

Skills and abilities:

  • Experience with NMR spectroscopy and X-ray crystallography, biophysical analysis of protein interactions, molecular biology, and protein expression.

Application procedure

Candidates should not have obtained a Ph.D. before 2018. Ph.D. students who are nearing graduation may also apply.

Interested candidates should submit a full CV, a one-page statement of research interests, and electronic copies of up to three first-author publications in a single PDF attachment to the email address: bordenlabjobs@gmail.com.

We thank all applicants for their interest. Please take note, however, that only shortlisted candidates for the position will be contacted by email for an interview.

Employment Equity Program

IRIC and Université de Montréal uphold the principles of employment equity and encourages applications from women, members of visible minorities, ethnic minorities, persons with disabilities and Aboriginal people.

Immigration requirements

In compliance with Canadian immigration requirements, priority shall be given to Canadian citizens and permanent residents.