81 résultats
No correlative evidence of costs of infection or immunity on leucocyte telomere length in a wild population of Soay sheep.
Ravindran S, Underwood SL, Dorrens J, Seeker LA, Watt K, Wilbourn RV, Sparks AM, Sinclair R, Chen Z, Pilkington JG, McNeilly TN, Harrington L, Pemberton JM, Nussey DH, Froy H
Proc Biol Sci
2024-04-03
;291(
2020
):20232946.
A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging.
Borges G, Benslimane Y, Harrington L
Biogerontology
2024-02-04
;.
The association between female reproductive performance and leukocyte telomere length in wild Soay sheep.
Ravindran S, Froy H, Underwood SL, Dorrens J, Seeker LA, Watt K, Wilbourn RV, Pilkington JG, Harrington L, Pemberton JM, Nussey DH
Mol Ecol
2022-12-01
;31(
23
):6184-6196.
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.
Stock AJ, McDevitt RA, Puligilla C, Wang Y, Zhang Y, Wang K, Sun C, Becker KG, Lehrmann E, Wood WH, Gong Y, Aqdas M, Sung MH, Hoffmann V, Liu C, Gorospe M, Harrington L, Ferrucci L, Liu Y
PLoS Genet
2022-11-01
;18(
11
):e1010506.
Tieing together loose ends: telomere instability in cancer and aging.
Borges G, Criqui M, Harrington L
Mol Oncol
2022-09-01
;16(
18
):3380-3396.
Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.
Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PED, Deng T, Chen NJ, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus E
EMBO J
2022-02-15
;41(
4
):e106825.
CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation.
Daouda T, Dumont-Lagacé M, Feghaly A, Benslimane Y, Panes R, Courcelles M, Benhammadi M, Harrington L, Thibault P, Major F, Bengio Y, Gagnon E, Lemieux S, Perreault C
PLoS Comput Biol
2021-10-22
;17(
10
):e1009482.
Heritable variation in telomere length predicts mortality in Soay sheep.
Froy H, Underwood SL, Dorrens J, Seeker LA, Watt K, Wilbourn RV, Pilkington JG, Harrington L, Pemberton JM, Nussey DH
Proc Natl Acad Sci U S A
2021-04-13
;118(
15
):.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Benslimane Y, Sánchez-Osuna M, Coulombe-Huntington J, Bertomeu T, Henry D, Huard C, Bonneil E, Thibault P, Tyers M, Harrington L
Aging Cell
2021-03-04
;e13331.
Catechin from Burkea africana Hook. Exhibits in vitro inhibition of human telomerase activity.
Eboji OK, Borges G, Harrington L, Lin W, Sofidiya MO, Sowemimo AA
Nat Prod Res
2020-10-14
;1-5.
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
Sun C, Wang K, Stock AJ, Gong Y, Demarest TG, Yang B, Giri N, Harrington L, Alter BP, Savage SA, Bohr VA, Liu Y
EMBO J
2020-09-16
;e103420.
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.
Benslimane Y, Bertomeu T, Coulombe-Huntington J, McQuaid M, Sánchez-Osuna M, Papadopoli D, Avizonis D, Russo MST, Huard C, Topisirovic I, Wurtele H, Tyers M, Harrington L
Mol Cell
2020-09-03
;79(
5
):846-856.e8.
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.
Criqui M, Qamra A, Chu TW, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington L
Elife
2020-04-16
;9:.
Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration.
Dumont-Lagacé M, Daouda T, Depoërs L, Zumer J, Benslimane Y, Brochu S, Harrington L, Lemieux S, Perreault C
Front Immunol
2020-02-11
;10:3118.
Editorial overview: The instability of the cancer genome: it starts at the end.
Harrington L, Baird DM
Curr. Opin. Genet. Dev.
2020-02-01
;60:iii-vi.
Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.
Belmonte FR, Dedousis N, Sipula I, Desai NA, Singhi AD, Chu Y, Zhang Y, Bannwarth S, Paquis-Flucklinger V, Harrington L, Shiva S, Jurczak MJ, O'Doherty RM, Kaufman BA
PLoS ONE
2019-05-28
;14(
5
):e0203101.
In medio stat virtus : unanticipated consequences of telomere dysequilibrium.
Harrington L, Pucci F
Philos. Trans. R. Soc. Lond., B, Biol. Sci.
2018-03-05
;373(
1741
):.
Understanding diversity in telomere dynamics.
Monaghan P, Eisenberg DTA, Harrington L, Nussey D
Philos. Trans. R. Soc. Lond., B, Biol. Sci.
2018-03-05
;373(
1741
):.
Mammographic density, blood telomere length and lipid peroxidation.
Erdmann NJ, Harrington L, Martin LJ
Sci Rep
2017-07-19
;7(
1
):5803.
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PB
Cancer Cell
2016-06-13
;29(
6
):859-73.
Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A
J. Med. Chem.
2016-05-26
;59(
10
):4697-710.
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Bannwarth S, Berg-Alonso L, Augé G, Fragaki K, Kolesar JE, Lespinasse F, Lacas-Gervais S, Burel-Vandenbos F, Villa E, Belmonte F, Michiels JF, Ricci JE, Gherardi R, Harrington L, Kaufman BA, Paquis-Flucklinger V
Mitochondrion
2016-02-23
;.
Lifelong leukocyte telomere dynamics and survival in a free-living mammal.
Fairlie J, Holland R, Pilkington JG, Pemberton JM, Harrington L, Nussey DH
Aging Cell
2016-02-01
;15(
1
):140-8.
The lighthouse at the end of the chromosome.
Benslimane Y, Harrington L
F1000Res
2015-12-11
;4:.
Defective repair of uracil causes telomere defects in mouse hematopoietic cells.
Vallabhaneni H, Zhou F, Maul RW, Sarkar J, Yin J, Lei M, Harrington L, Gearhart PJ, Liu Y
J. Biol. Chem.
2015-02-27
;290(
9
):5502-11.
Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation.
Fairlie J, Harrington L
DNA Repair (Amst.)
2014-11-24
;25C:54-59.
Targeted protein degradation as a tumor suppressor.
Arat NO, Harrington L
Cell Cycle
2014-11-15
;13(
22
):3473.
Break-induced replication requires DNA damage-induced phosphorylation of pif1 and leads to telomere lengthening.
Vasianovich Y, Harrington L, Makovets S
PLoS Genet.
2014-10-01
;10(
10
):e1004679.
Short Telomeres in ESCs Lead to Unstable Differentiation.
Pucci F, Gardano L, Harrington L
Cell Stem Cell
2013-04-04
;12(
4
):479-86.
A yeast chemical genetic screen identifies inhibitors of human telomerase.
Wong LH, Unciti-Broceta A, Spitzer M, White R, Tyers M, Harrington L
Chem. Biol.
2013-03-21
;20(
3
):333-40.
Cancer: Trouble upstream.
Patton EE, Harrington L
Nature
2013-03-21
;495(
7441
):320-1.
Telomeres, a busy platform for cell signaling.
Gardano L, Pucci F, Christian L, Le Bihan T, Harrington L
Front Oncol
2013-01-01
;3:146.
Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin.
Gardano L, Holland L, Oulton R, Le Bihan T, Harrington L
Nucleic Acids Res.
2012-03-01
;40(
5
):e36.
Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.
Taboski MA, Sealey DC, Dorrens J, Tayade C, Betts DH, Harrington L
Cell Rep
2012-02-23
;1(
2
):91-8.
Haploinsufficiency and telomere length homeostasis.
Harrington L
Mutat. Res.
2012-02-01
;730(
1-2
):37-42.
PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.
Reynolds GE, Gao Q, Miller D, Snow BE, Harrington L, Murnane JP
DNA Repair (Amst.)
2011-11-10
;10(
11
):1164-73.
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
Sealey DC, Kostic AD, Lebel C, Pryde F, Harrington L
BMC Mol. Biol.
2011-01-01
;12:45.
The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization.
Sealey DC, Zheng L, Taboski MA, Cruickshank J, Ikura M, Harrington L
Nucleic Acids Res.
2010-04-01
;38(
6
):2019-35.
Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells.
Rashid-Kolvear F, Taboski MA, Nguyen J, Wang DY, Harrington L, Done SJ
BMC Cancer
2010-01-01
;10:390.
Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.
Lebel C, Rosonina E, Sealey DC, Pryde F, Lydall D, Maringele L, Harrington L
Genetics
2009-07-01
;182(
3
):671-84.
No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells.
Erdmann N, Harrington L
DNA Repair (Amst.)
2009-03-01
;8(
3
):347-53.
Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.
Meznikova M, Erdmann N, Allsopp R, Harrington L
Dis Model Mech
2009-01-01
;2(
11-12
):620-6.
Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo.
Snow BE, Mateyak M, Paderova J, Wakeham A, Iorio C, Zakian V, Squire J, Harrington L
Mol. Cell. Biol.
2007-02-01
;27(
3
):1017-26.
The retinoblastoma protein regulates pericentric heterochromatin.
Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binné UK, Harrington L, Sicinski P, Bérubé NG, Dyson NJ, Dick FA
Mol. Cell. Biol.
2006-05-01
;26(
9
):3659-71.
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D
Cell
2006-03-24
;124(
6
):1155-68.
Quantitative analysis of telomerase activity and telomere length in domestic animal clones.
Betts DH, Perrault S, Harrington L, King WA
Methods Mol. Biol.
2006-01-01
;325:149-80.
Strict control of telomerase activation using Cre-mediated inversion.
Ungrin MD, Harrington L
BMC Biotechnol.
2006-01-01
;6:10.
The effect of TERC haploinsufficiency on the inheritance of telomere length.
Goldman F, Bouarich R, Kulkarni S, Freeman S, Du HY, Harrington L, Mason PJ, Londoño-Vallejo A, Bessler M
Proc. Natl. Acad. Sci. U.S.A.
2005-11-22
;102(
47
):17119-24.
Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells.
Wang JC, Warner JK, Erdmann N, Lansdorp PM, Harrington L, Dick JE
Proc. Natl. Acad. Sci. U.S.A.
2005-10-04
;102(
40
):14398-403.
Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.
Warner JK, Wang JC, Takenaka K, Doulatov S, McKenzie JL, Harrington L, Dick JE
Leukemia
2005-10-01
;19(
10
):1794-805.