150 résultats
CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.
Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Duramé E, Sahmi M, Garrido D, Lefrançois M, Arseneault G, Saba-El-Leil MK, Meloche S, Emery G, Therrien M
Nat Commun
2023-06-15
;14(
1
):3560.
Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen.
Pelletier B, Duhamel S, Tambutet G, Jarvis S, Cléroux P, David M, Tanguay PL, Voisin L, James C, Lavoie R, Gareau Y, Flynn-Robitaille J, Lorca T, Ruel R, Marinier A, Meloche S
ACS Chem Biol
2023-05-19
;18(
5
):1039-1046.
Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy.
Javary J, Goupil E, Soulez M, Kanshin E, Bouchard A, Seternes OM, Thibault P, Labbé J, Meloche S
J Cell Physiol
2022-12-28
;.
On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer.
Boudghene-Stambouli F, Soulez M, Ronkina N, Dörrie A, Kotlyarov A, Seternes OM, Gaestel M, Meloche S
Cancers (Basel)
2022-12-21
;15(
1
):.
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean E, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP
Nat Commun
2022-10-29
;13(
1
):6457.
Development of a high-throughput assay to identify inhibitors of the ubiquitin-conjugating enzyme UBCH10.
Cléroux P, Voisin L, Meloche S
SLAS Discov
2022-06-01
;27(
4
):266-271.
YES, a novel therapeutic target in hepatocellular carcinoma.
Lapouge M, Meloche S
Mol Cell Oncol
2022-05-01
;9(
1
):2069993.
ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation.
Soulez M, Tanguay PL, Dô F, Dort J, Crist C, Kotlyarov A, Gaestel M, Ferron M, Dumont NA, Meloche S
J Cell Physiol
2022-04-01
;237(
4
):2271-2287.
Signaling by the tyrosine kinase Yes promotes liver cancer development.
Guégan JP, Lapouge M, Voisin L, Saba-El-Leil MK, Tanguay PL, Lévesque K, Brégeon J, Mes-Masson AM, Lamarre D, Haibe-Kains B, Trinh VQ, Soucy G, Bilodeau M, Meloche S
Sci Signal
2022-01-18
;15(
717
):eabj4743.
Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential.
Mathien S, Tesnière C, Meloche S
Pharmacol Rev
2021-10-01
;73(
4
):263-296.
Interleukin-17 Receptor D in Physiology, Inflammation and Cancer.
Girondel C, Meloche S
Front Oncol
2021-03-23
;11:656004.
Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.
Girondel C, Lévesque K, Langlois MJ, Pasquin S, Saba-El-Leil MK, Rivard N, Friesel R, Servant MJ, Gauchat JF, Lesage S, Meloche S
Oncogene
2021-01-01
;40(
2
):452-464.
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP
Nat Commun
2020-07-24
;11(
1
):3701.
Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.
Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche S
Mol. Cell. Biol.
2019-03-15
;39(
6
):.
A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.
Fink S, Zugelder L, Roth B, Brandt E, Meloche S, Izsvák Z, Bargou RC, Stühmer T
PLoS ONE
2018-10-19
;13(
10
):e0205585.
Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.
Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit R
Mol. Cell. Biol.
2017-12-15
;37(
24
):.
Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.
Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD
Bioconjug. Chem.
2017-06-21
;28(
6
):1677-1683.
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.
Mathien S, Déléris P, Soulez M, Voisin L, Meloche S
Mol. Cell. Biol.
2017-05-01
;37(
9
):.
Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling.
Saba-El-Leil MK, Frémin C, Meloche S
Methods Mol. Biol.
2017-01-01
;1487:243-253.
ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.
Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche S
Oncogene
2016-10-27
;35(
43
):5692-5698.
Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.
Pew BK, Harris RA, Sbrana E, Guaman MC, Shope C, Chen R, Meloche S, Aagaard K
Am. J. Obstet. Gynecol.
2016-09-01
;215(
3
):384.e1-384.e89.
Redundancy in the World of MAP Kinases: All for One.
Saba-El-Leil MK, Frémin C, Meloche S
Front Cell Dev Biol
2016-06-27
;4:67.
Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.
Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche S
Cell Cycle
2016-06-17
;15(
12
):1631-42.
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.
Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G
Blood
2016-06-16
;127(
24
):3054-61.
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G
Nat. Genet.
2015-09-01
;47(
9
):1030-7.
Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development.
Frémin C, Saba-El-Leil MK, Lévesque K, Ang SL, Meloche S
Cell Rep
2015-08-11
;12(
6
):913-21.
The atypical MAPK ERK3 controls positive selection of thymocytes.
Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque N
Immunology
2015-05-01
;145(
1
):161-9.
E4F1 Is a Master Regulator of CHK1-Mediated Functions.
Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G
Cell Rep
2015-04-15
;11(
2
):210-219.
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau G, Boutonnet C, Meloche S, Sauvageau G
Blood
2014-10-09
;124(
15
):2362-9.
The Catalytic Activity of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 3 Is Required To Sustain CD4+ CD8+ Thymocyte Survival.
Marquis M, Daudelin JF, Boulet S, Sirois J, Crain K, Mathien S, Turgeon B, Rousseau J, Meloche S, Labrecque N
Mol. Cell. Biol.
2014-09-15
;34(
18
):3374-87.
Towards the development of chromone-based MEK1/2 modulators.
Redwan IN, Dyrager C, Solano C, Fernández de Trocóniz G, Voisin L, Bliman D, Meloche S, Grøtli M
Eur J Med Chem
2014-07-07
;85C:127-138.
Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.
Cuevas Guaman M, Sbrana E, Shope C, Showalter L, Hu M, Meloche S, Aagaard K
Pediatr. Res.
2014-07-01
;76(
1
):24-32.
The Non-Classical MAP Kinase ERK3 Controls T Cell Activation.
Marquis M, Boulet S, Mathien S, Rousseau J, Thébault P, Daudelin JF, Rooney J, Turgeon B, Beauchamp C, Meloche S, Labrecque N
PLoS ONE
2014-01-27
;9(
1
):e86681.
ERKs in Cancer: Friends or Foes?
Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G
Cancer Res.
2014-01-15
;74(
2
):412-9.
NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.
Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J
Blood
2013-06-27
;121(
26
):5203-7.
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden K, Meloche S, Roux PP
Oncogene
2013-06-13
;32(
24
):2917-26.
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.
Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G
Genes Dev.
2013-04-15
;27(
8
):900-15.
Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.
Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault P
Mol. Syst. Biol.
2013-01-01
;9:669.
Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.
Trost M, Sauvageau G, Hérault O, Deleris P, Pomiès C, Chagraoui J, Mayotte N, Meloche S, Sauvageau G, Thibault P
Blood
2012-08-23
;120(
8
):e17-27.
Proteomic Profiling of the TRAF3 Interactome Network Reveals a New Role for the ER-to-Golgi Transport Compartments in Innate Immunity.
van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S, Servant MJ
PLoS Pathog.
2012-07-01
;8(
7
):e1002747.
The Extracellular Signal-Regulated Kinase 3 (Mitogen-Activated Protein Kinase 6 [MAPK6])-MAPK-Activated Protein Kinase 5 Signaling Complex Regulates Septin Function and Dendrite Morphology.
Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A
Mol. Cell. Biol.
2012-07-01
;32(
13
):2467-78.
Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S
Cancer Res.
2012-02-01
;72(
3
):626-35.
F-box proteins elongate translation during stress recovery.
Meloche S, Roux PP
Sci Signal
2012-01-01
;5(
227
):pe25.
Liver fibrosis protects mice from acute hepatocellular injury.
Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M
Gastroenterology
2012-01-01
;142(
1
):130-139.e4.
ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses.
Courcelles M, Lemieux S, Voisin L, Meloche S, Thibault P
Proteomics
2011-07-01
;11(
13
):2654-71.
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F
Cell
2011-06-24
;145(
7
):1075-87.
Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden K, Thibault P, Meloche S
J. Biol. Chem.
2011-02-25
;286(
8
):6470-8.
A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.
Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P
Mol. Cell Proteomics
2011-02-01
;10(
2
):M110.004796.
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.
Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD
Circ. Res.
2011-01-21
;108(
2
):176-83.
Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.
Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, Poirier-Héon JF, Davoli MA, Mechawar N, El Mestikawy S, Cermakian N, Meloche S
Mol. Cell. Biol.
2010-12-01
;30(
24
):5752-63.