Publication — IRIC

Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

IKKε is an oncogenic kinase that was found amplified and overexpressed in a substantial percentage of human breast cancer cell lines and primary tumors using genomic and gene expression analyses. Molecular studies have provided the rational for a key implication of IKKε in breast cancer cells proliferation and invasiveness through the phosphorylation of several substrates.

Date de publication
22 mai 2017
Chercheurs
Williams V, Grosset AA, Zamorano Cuervo N, St-Pierre Y, Sylvestre MP, Gaboury L, Grandvaux N
Référence PubMed
BMC Cancer 2017;17(1):356
ID PubMed
28532474
Affiliation
CRCHUM - Centre de recherche du Centre Hospitalier de l’Université de Montréal, 900 rue Saint-Denis, Montréal, Qc H2X 0A9, Canada.