Publication — IRIC

Liver fibrosis protects mice from acute hepatocellular injury.

Development of fibrosis is part of the pathophysiologic process of chronic liver disease. Although it is considered deleterious, it also represents a form of tissue repair. Deposition of extracellular matrix changes the cellular environment of the liver; we investigated whether it increases resistance to noxious stimuli and the role of changes in intracellular signaling to hepatocytes in mediating this effect.

Date de publication
1er janvier 2012
Chercheurs
Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M
Référence PubMed
Gastroenterology 2012;142(1):130-139.e4
ID PubMed
21945831
Affiliation
Laboratoire d’Hépatologie Cellulaire du Centre de Recherche du CHUM-Hôpital Saint-Luc, Montréal, Québec, Canada.