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MAP kinase module: the Ksr connection.

Ksr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role has been unclear. New studies now provide evidence that Ksr is important for signal transmission within the MAP kinase module, where it apparently acts as a location-regulated scaffold connecting MEK to Raf.

Date de publication
30 avril 2002
Chercheur(euse)s
Roy F, Therrien M
Référence PubMed
Curr. Biol. 2002;12(9):R325-7
ID PubMed
12007434
Affiliation
Laboratory of Intracellular Signaling, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, PQ Canada, H2W 1R7.