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Publication — IRIC

Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML.

Acute myeloid leukemia (AML) stem cells (LSCs) are capable of surviving current standard chemotherapy and are the likely source of deadly, relapsed disease. While stem cell transplant serves as proof-of-principle that AML LSCs can be eliminated by the immune system, the translation of existing immunotherapies to AML has been met with limited success. Consequently, understanding and exploiting the unique immune-evasive mechanisms of AML LSCs is critical.

Date de publication
1er juillet 2021
Chercheur(euse)s
Herbrich S, Baran N, Cai T, Weng C, Aitken MJL, Post SM, Henderson J, Shi C, Richard-Carpentier G, Sauvageau G, Baggerly K, Al-Atrash G, Davis RE, Daver N, Zha D, Konopleva M
Référence PubMed
J Immunother Cancer 2021;9(7)
ID PubMed
34326171
Affiliation
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.