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Publication — IRIC

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs.

Lifelong production of the many types of mature blood cells from less differentiated progenitors is a hierarchically ordered process that spans multiple cell divisions. The nature and timing of the molecular events required to integrate the environmental signals, transcription factor activity, epigenetic modifications, and changes in gene expression involved are thus complex and still poorly understood. To address this gap, we generated comprehensive reference epigenomes of 8 phenotypically defined subsets of normal human cord blood.

Date de publication
13 May 2022
Lorzadeh A, Hammond C, Wang F, Knapp D, Wong JC, Zhu JYA, Cao Q, Heravi-Moussavi A, Carles A, Wong M, Sharafian Z, Steif J, Moksa M, Bilenky M, Lavoie PM, Eaves CJ, Hirst M
Référence PubMed
BMC Biol 2022;20(1):104
ID PubMed
Department of Microbiology and Immunology, Michael Smith Laboratories, UBC, Vancouver, Canada.