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Identification of novel biomarkers for MLL translocated acute myeloid leukemia.

Lagacé K, Barabé F, Hebert J, Cellot S, Wilhelm BT

Laboratory for High throughput biology, Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada.

Acute myeloid leukemias (AML) with translocations of the Mixed Lineage Leukemia (MLL/KMT2A) gene are common in young patients and are generally associated with poor clinical outcomes. The molecular biology of MLL fusion genes remains incompletely characterized and is complicated by the fact that over 100 different partner genes have been identified in fusions with MLL. The continually growing list of MLL fusions also represents a clinical challenge with respect to identification of novel fusions and tracking the fusions to monitor progression of the disease after treatment. We have recently developed a novel single donor model leukemia system that permits the development of human AML from normal cord blood cells. Gene expression analysis of this model and MLL-AML patient samples has identified a number of candidate biomarker genes with highly biased expression on leukemic cells. Here we present the data demonstrating the potential clinical utility of several of these candidate genes for identifying known and novel MLL fusions.

Exp. Hematol. 2017.

Pubmed ID: 28911906

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