A new strategy based on copper overdose to treat AML
Despite the therapeutic advances of recent years in the treatment of acute myeloid leukemia (AML), this pathology remains associated with a poor prognosis. In a new study, the Leucegene group led by Guy Sauvageau, Director of IRIC’s Molecular Genetics of Stem Cells Research Unit, Anne Marinier, Director of IRIC’s Drug Discovery Unit, and Josée Hébert (Banque de cellules leucémiques du Québec (BCLQ), Maisonneuve-Rosemont Hospital Research Center) proposes a therapeutic strategy based on copper overdose as a treatment for a genetic subgroup of AML particularly sensitive to this approach. Led by Céline Moison and Deanne Gracias (biology), and Julie Schmitt and Réjean Ruel (chemistry), in collaboration with the BCLQ genetics laboratory team, this project has been published in the prestigious journal Science Advances.