IRIC - Institute for Research in Immunology and Cancer

Making breast cancer cells more visible to the immune system

The team led by Pierre Thibault, Director of IRIC’s Proteomics and Mass Spectrometry Research Unit, has discovered that abemaciclib, used to treat hormone receptor-positive metastatic breast cancer, reprograms the antigenic profile of tumors—a characteristic that could be exploited to improve treatment efficacy. Led by doctoral student Robin Minati, this study has just been published in the journal Cell Reports. It is the result of a close collaboration with the team of Claude Perreault, Director of IRIC’s Immunobiology Research Unit.

A novel role for pH in protein regulation

The team led by Sylvain Meloche, Director of IRIC’s Signalling and Cell Growth Research Unit, has discovered a new mechanism for the global regulation of proteins by intracellular pH. The study, co-led by PhD students Chloé Tesnière and Fadia Boudghene-Stambouli, has been published in the journal PNAS. The teams led by Pierre Thibault, Director of IRIC’s Proteomics and Mass Spectrometry Research Unit, Laurent Counillon, Director of the Molecular Physio-Medicine Laboratory at CNRS-Université Côte d’Azur (Nice, France), and Stine F. Pedersen d of the University of Copenhagen also contributed to the project.

National Philanthropy Day: Giving Youth a Voice!

November 15, 2025, is National Philanthropy Day across Canada. This day is an opportunity to honor philanthropists and their impact on society. IRIC has chosen to highlight the recent achievements of the IRIC Young Philanthropists Committee and some of the faces behind the committee’s success. IRIC is proud to introduce two of its founding members: Katrina Kontaxis and Benjamin Raynauld.

A colorful pickleball tournament for Young Philanthropists to benefit IRIC!

On October 26, IRIC’s Young Philanthropists held their eagerly awaited event at the Atwater Club. On the agenda? A pickleball tournament and a distinguished brunch! It was a bold and perfectly executed formula that brought together nearly 150 participants from Montreal’s next generation, all present for the cause.

An IRIC team attends the event “Light The Night”

On October 25, a team of nearly thirty people from IRIC took part in the “Light the Night” walk organized by the Leukemia & Lymphoma Society of Canada.

Breast cancer: our teams are mobilized day after day

octobre 1—novembre 15, 2025

In this month of awareness, we focus on some of our researchers who are working tirelessly through multiple initiatives to make a difference in breast cancer.