A unique model
IRIC, located in the heart of the Université de Montréal campus, operates according to a unique model in Canada that combines, under one roof, fundamental research activities, a university-level training program and a research maturation team. These generate discoveries that advance knowledge or that can quickly translate into new therapeutic solutions.
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News UM171 breaks new ground
Just a few years ago, there was little hope for people suffering from hematological malignancies requiring stem cell transplants, such as acute leukemia and myelodysplastic syndromes. Today, thanks to the work of Guy Sauvageau and Anne Marinier, new treatment options are gradually entering the market worldwide. Experts in the molecular genetics of stem cells and medicinal chemistry respectively, the two IRIC scientists and UdeM professors were behind the discovery of the UM171 molecule, which saw the light of day in 2014.
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News Student researchers honoured at IRIC’s 11th Scientific Day!
The 11th Scientific Day, held on June 12, highlighted the work of IRIC’s scientific community. Nearly 190 people attended and had the opportunity to attend nine oral presentations, six flash presentations, and 50 poster presentations. To highlight the knowledge of the next generation of scientists, seven poster presentation awards and two oral presentation awards were presented.
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News Success for IRIC at the Festival Eurêka! 2025
On May 30, live from Île Sainte-Hélène, IRIC took part in the 18th edition of the Festival Eurêka! This festival is an opportunity for families and up-and-coming young people to immerse themselves in the world of scientific discovery.
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News A Coup de Coeur for Éric Bonneil at the 2025 Rector’s Awards at the Université de Montréal
The Université de Montréal’s Rector’s Awards 2025 were presented on May 29 to highlight the remarkable contributions of staff members whose commitment and achievements exemplify the values of the University. IRIC is proud to recognize Éric Bonneil, Manager of the Proteomics Core Facility, as Coup de Coeur in the Innovation category.
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News Meet Doris Alexandra Schuetz, Principal Research Advisor, Drug Discovery Unit
Doris Alexandra Schuetz is an inspiration to many members of the IRIC community. A committed professional dedicated to the fight against cancer on a daily basis, Doris also excels at running, a sport she has been practising for several years now. Eager to combine business with pleasure, Doris has raised close to $5,000 for cancer research at IRIC since 2022, through her participation in the Montreal Beneva Marathon. IRIC is proud to introduce you to this inspiring person.
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News BRAF mutants escape stopped by therapeutic “agents”
The team led by Marc Therrien, CEO and Director of IRIC’s Intracellular Signaling Research Unit, has identified major structural changes that enable the BRAF protein to escape control and mimic its activation, giving it strong oncogenic potential. What’s more, the researchers succeeded in completely restoring the protein’s normal conformational state using small molecules – a breakthrough. The study, published in the prestigious journal Science, is the joint work of Hugo Lavoie (Associate Director), Ting Jin (Research Advisor) and Driss Lajoie (Research Advisor), who are the co-first authors. It is part of a close collaboration between several research teams which, in addition to the Therrien laboratory, involves teams from NYU Langone (New York), Université de Bordeaux and the University of Calgary.
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News IRIC Gala Audace: $1,060,025 raised for cancer research
On April 9, the 2025 edition of the Gala Audace of the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal was held. Thanks to the generosity of over 300 guests at the Marché Bonsecours, our valued donors and sponsors, a total of $1,060,025 was raised to support cancer research at IRIC.
Upcoming events
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February 15, 2024—August 31, 2025 Université de Montréal launches “L’heure est brave” campaign
To meet the major challenges of our time, the Université de Montréal is launching the “L’heure est brave” campaign. By contributing, you will help the University to develop the potential of its students, innovate for the common good, look after the health of living beings and improve the daily lives of communities. Your donations can make a difference. Let’s join forces to build tomorrow’s world.
Latest publications
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June 12, 2025 CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity.
Rodriguez MM, Chatterjee D, Guerry J, Patenaude AM, Cohen CCH, Bois T, Larouche A, Ferreira SR, Bertomeu T, Chatr-Aryamontri A, Zhang L, Mader S, Nislow C, St-Jean G, Guindon Y, Zahn A, Di Noia JM
Proc Natl Acad Sci U S A 2025-06-12 ;122( 24 ):e2424409122 -
June 11, 2025 Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R.
Morales-Pastor A, Miljuš T, Dieguez-Eceolaza M, Stępniewski TM, Ledesma-Martin V, Heydenreich FM, Flock T, Plouffe B, Le Gouill C, Duchaine J, Sykes DA, Nicholson C, Koers EJ, Guba W, Rufer AC, Grether U, Bouvier M, Veprintsev DB, Selent J
Nat Commun 2025-06-11 ;16( 1 ):5265 - See all publications