Latest publications
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July 1, 2025 O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis.
Ahmed O, Masclef L, Iannantuono N, Gagnon J, Gushul-Leclaire M, Boulay K, Estavoyer B, Echbicheb M, Ali Boubacar K, Poy M, Boubekeur A, Menggad S, Schcolnik-Cabrera A, Balsalobre A, Bonneil E, Thibault P, Hulea L, Mallette FA, Drouin J, Tanaka Y, Affar EB
Nat Commun 2025-07-01 ;16( 1 ):5959 -
June 30, 2025 Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.
Jayashankar V, Kubiniok P, McCracken AN, Gentry RG, Eckenstein KH, Sernissi L, Vece V, Garsi JB, Valles SY, Jung S, Hoffman NC, Perrochon AS, Selwan EM, Finicle BT, Pitman M, Lin D, Bonneil E, Xu R, Mao C, Kaiser P, Fruman DA, Mobley D, Jang C, Hanessian S, Thibault P, Edinger AL
EMBO J 2025-06-30 ; -
June 12, 2025 CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity.
Rodriguez MM, Chatterjee D, Guerry J, Patenaude AM, Cohen CCH, Bois T, Larouche A, Ferreira SR, Bertomeu T, Chatr-Aryamontri A, Zhang L, Mader S, Nislow C, St-Jean G, Guindon Y, Zahn A, Di Noia JM
Proc Natl Acad Sci U S A 2025-06-12 ;122( 24 ):e2424409122 -
June 11, 2025 Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R.
Morales-Pastor A, Miljuš T, Dieguez-Eceolaza M, Stępniewski TM, Ledesma-Martin V, Heydenreich FM, Flock T, Plouffe B, Le Gouill C, Duchaine J, Sykes DA, Nicholson C, Koers EJ, Guba W, Rufer AC, Grether U, Bouvier M, Veprintsev DB, Selent J
Nat Commun 2025-06-11 ;16( 1 ):5265 -
May 29, 2025 BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Lavoie H, Jin T, Lajoie D, Decossas M, Gendron P, Wang B, Filandr F, Sahmi M, Hwa Jo C, Weber S, Arseneault G, Tripathy S, Beaulieu P, Schuetz DA, Schriemer DC, Marinier A, Rice WJ, Maisonneuve P, Therrien M
Science 2025-05-29 ;388( 6750 ):eadp2742 -
May 22, 2025 Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer.
Apavaloaei A, Zhao Q, Hesnard L, Cahuzac M, Durette C, Larouche JD, Hardy MP, Vincent K, Brochu S, Laverdure JP, Lanoix J, Courcelles M, Gendron P, Lajoie M, Ruiz Cuevas MV, Kina E, Perrault J, Humeau J, Ehx G, Lemieux S, Watson IR, Speiser DE, Bassani-Sternberg M, Thibault P, Perreault C
Nat Cancer 2025-05-22 ;