Identification of a new key role for interphase microtubules at mitosis entry
At the beginning of cell division, cells round-up through different mechanisms, notably the reorganization of their cortex. Among the proteins involved in this cell morphogenesis, there is the family of ERM proteins (ezrin, radixin and moesin). The team of Professor Sébastien Carréno, Director of the Cellular Mechanisms of Morphogenesis during Mitosis and Cell Motility Research Unit, wanted to identify the molecular cue activating these proteins at mitotic entry. Their work has shed light on a novel mechanism involving interphase microtubules in the regulation of cell rounding at mitotic onset. The project, led by PhD student Kévin Leguay, is the subject of a publication in the Journal of Cell Biology.