Acquiring new knowledge and accelerating the discovery of new therapies

Our innovative approach to research leads to making discoveries that have a major impact in the fight against cancer.

All cancers are the result of genetic alterations in one cell of our body, which results in said cell becoming abnormal, which then leads to a disorderly cell proliferation and tumor formation.

More than 200 different types of cancer can be caused by a number of different mutations producing specific anomalies at the molecular and cellular level.

Traditional therapeutic approaches such a chemotherapy and radiation therapy are nonspecific and are often accompanied by significant adverse side effects.

IRIC Investigators are working towards acquiring new knowledge to better understand the mechanisms of cancer and to develop personalized therapeutic approaches.

Publications

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  • May 1, 2019

    Chemogenetics defines receptor-mediated functions of short chain free fatty acids.

    Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G
    Nat. Chem. Biol. 2019-05-01 ;15( 5 ):489-498.

  • April 5, 2019

    Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.

    Cyr P, Flynn-Robitaille J, Boissarie P, Marinier A
    Org. Lett. 2019-04-05 ;21( 7 ):2265-2268.

  • April 2, 2019

    Identification of Allosteric Inhibitors against Active Caspase-6.

    Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC
    Sci Rep 2019-04-02 ;9( 1 ):5504.

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News

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  • May 2, 2019

    The eIF4E factor reveals itself in a new way

    This discovery made by a team of IRIC Investigators could make its way into cell biology textbooks. The laboratory of Katherine L.B. Borden recently published a study in Cell Reports revealing a new role for the eIF4E factor: actively participating in the cleavage of the terminal end of messenger RNAs in order to accelerate their conversion to protein.

  • December 16, 2018

    Sébastien Lemieux appointed Associate Professor in the Department of Biochemistry and Molecular Medicine of the Faculty of Medicine of the Université de Montréal

    IRIC is proud to announce the appointment of Sébastien Lemieux to the position of Associate Professor in the Department of Biochemistry and Molecular Medicine of the Faculty of Medicine of the University of Montreal.

  • December 6, 2018

    One step closer to developing a therapeutic cancer vaccine

    The most recent discovery of Dr. Claude Perreault and his team, as explained in Science Translational Medicine magazine

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Events

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  • 2—6 June, 2019

    Canadian Society for Molecular Biosciences – 62ndAnnual Conference

    From June 2 to June 5, 2019, IRIC hosted the largest conference ever held there: the 62nd Annual Conference of the Canadian Society for Molecular Biosciences (CSMB) – Model Systems in Cancer Research.

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