IRIC - Institute for Research in Immunology and Cancer

Chemogenetics defines receptor-mediated functions of short chain free fatty acids.

Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G
Nat. Chem. Biol. 2019-05-01 ;15( 5 ):489-498.

Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.

Cyr P, Flynn-Robitaille J, Boissarie P, Marinier A
Org. Lett. 2019-04-05 ;21( 7 ):2265-2268.

Identification of Allosteric Inhibitors against Active Caspase-6.

Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC
Sci Rep 2019-04-02 ;9( 1 ):5504.

Speeding up the drug discovery process to help patients: Michel Bouvier co-senior author of a study published in Nature Communications

An international research team has developed a new strategy that can predict the potential clinical implications of new therapeutic compounds based on simple cellular responses. This discovery was partly led by scientists affiliated with Université de Montréal (UdeM), and represents a major step forward in developing more effective drugs with fewer side effects, much faster than before. The researchers conducted their work at Centre de Recherche de l’Hôpital Ste-Justine and published their findings in the prestigious journal Nature Communications.

 

The eIF4E factor reveals itself in a new way

This discovery made by a team of IRIC Investigators could make its way into cell biology textbooks. The laboratory of Katherine L.B. Borden recently published a study in Cell Reports revealing a new role for the eIF4E factor: actively participating in the cleavage of the terminal end of messenger RNAs in order to accelerate their conversion to protein.

Sébastien Lemieux appointed Associate Professor in the Department of Biochemistry and Molecular Medicine of the Faculty of Medicine of the Université de Montréal

IRIC is proud to announce the appointment of Sébastien Lemieux to the position of Associate Professor in the Department of Biochemistry and Molecular Medicine of the Faculty of Medicine of the University of Montreal.

One step closer to developing a therapeutic cancer vaccine

The most recent discovery of Dr. Claude Perreault and his team, as explained in Science Translational Medicine magazine

A Cell Biological Perspective on Localized Translation: The ER As A Privileged Translation Compartment in Health and Disease

Lecture Hall S1-151, Jean-Coutu Pavilion

Lecture by Dr. Christopher Nicchitta, Duke University School of Medicine, Durham, NC, USA, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

Leukemia Stem Cells: To Seek and Destroy

Lecture Hall S1-151, Jean-Coutu Pavilion

Lecture by Dr. Monica L. Guzman, Weill Cornell Medicine, New York, NY, USA, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

Central-acting aminopeptidase A inhibitors for new treatment of hypertension and heart failure: from discovery to clinical trial

Lecture Hall S1-111, Jean-Coutu Pavilion

Lecture by Dr. Catherine Llorens-Cortès, Collège de France, Paris, France, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

Establishing sister chromatid cohesion is a Belt and Braces job

Lecture Hall S1-151, Jean-Coutu Pavilion

Lecture by Dr. Kim Nasmyth, University of Oxford, Oxford, UK, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

Precision medicine in pediatric oncology, the study of rare pathologies in children by data integration: Unsupervised classification of Osteosarcoma associates the immune microenvironment to prognosis at diagnostic

Lecture Hall S1-111, Jean-Coutu Pavilion

Lecture by Dr. Antonin Marchais, Institut Gustave Roussy, Villejuif, France, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

The CD47-SIRPα innate immune checkpoint in cancer

Lecture Hall S1-151, Jean-Coutu Pavilion

Lecture by Dr. Timo K. van den Berg, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

Reprogramming of prostate cancer cell metabolism by the androgen receptor

Lecture Hall S1-151, Jean-Coutu Pavilion

Lecture by Dr. Etienne Audet-Walsh, Centre Hospitalier de l’Université Laval, Quebec City, QC, Canada, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

Cellular Mechanics

Lecture Hall S1-151, Jean-Coutu Pavilion

Lecture by Dr. Allen J. Ehrlicher, McGill University, Montréal, QC, Canada, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.

Pioneer activity of the HOX transcription factors in developing embryos

Lecture Hall S1-151, Jean-Coutu Pavilion

Lecture by Dr. Marie Kmita, Institut de recherches cliniques de Montréal, Montreal, QC, Canada, as part of the “Distinguished Scientist Lecture Series” Fall 2019, hosted by IRIC.