Publication — IRIC

Targeting copper metabolism to defeat KRAS-driven colorectal cancer.

KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically dependent on the copper transporter ATP7A, which reveals copper metabolism as a promising therapeutic target for KRAS-driven colorectal cancers.

Date de publication
7 octobre 2020
Aubert L, Nandagopal N, Roux PP
Référence PubMed
Mol Cell Oncol 2020;7(6):1822123
ID PubMed
Institute for Research in Immunology and Cancer (IRIC), Université De Montréal, Montreal, Quebec, Canada.