88 résultats
STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity.
De Jamblinne CV, Decelle B, Dehghani M, Joseph M, Sriskandarajah N, Leguay K, Rambaud B, Lemieux S, Roux PP, Hipfner DR, Carréno S
J Cell Biol
2020-11-02
;219(
11
):.
Targeting copper metabolism to defeat KRAS-driven colorectal cancer.
Aubert L, Nandagopal N, Roux PP
Mol Cell Oncol
2020-10-07
;7(
6
):1822123.
An ErbB2 splice variant lacking exon 16 drives lung carcinoma.
Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ
Proc. Natl. Acad. Sci. U.S.A.
2020-08-18
;117(
33
):20139-20148.
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP
Nat Commun
2020-07-24
;11(
1
):3701.
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.
Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith M, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G
Nat. Cell Biol.
2020-07-01
;22(
7
):803-814.
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carréno S, Roux PP
Cell Rep
2020-05-19
;31(
7
):107660.
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y
Am. J. Respir. Crit. Care Med.
2020-05-15
;201(
10
):1263-1276.
Controversies around the function of LARP1.
Berman AJ, Thoreen CC, Dedeic Z, Chettle J, Roux PP, Blagden SP
RNA Biol
2020-04-17
;1-11.
F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.
Serres MP, Samwer M, Truong Quang BA, Lavoie G, Perera U, Görlich D, Charras G, Petronczki M, Roux PP, Paluch EK
Dev. Cell
2020-01-29
;52(
2
):210-222.e7.
Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.
Méant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP
Mol. Cell Proteomics
2020-01-02
;19(
1
):50-64.
Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1.
Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Martin Schmeing T, Han Y, Downey J, Divangahi M, Roux PP, Kristof AS
Sci Rep
2019-12-09
;9(
1
):17620.
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad E, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm B, Cellot S
Blood Adv
2019-11-12
;3(
21
):3307-3321.
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children.
de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL
Genes Chromosomes Cancer
2019-10-01
;58(
10
):723-730.
Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration.
Plutoni C, Keil S, Zeledon C, Delsin LEA, Decelle B, Roux PP, Carréno S, Emery G
Nat Commun
2019-09-02
;10(
1
):3940.
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G
Cancer Cell
2019-07-08
;36(
1
):84-99.e8.
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.
Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO
Proc. Natl. Acad. Sci. U.S.A.
2019-02-19
;116(
8
):2967-2976.
Signaling Pathways Involved in the Regulation of mRNA Translation.
Roux PP, Topisirovic I
Mol. Cell. Biol.
2018-06-15
;38(
12
):.
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.
Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF
Cell Rep
2018-05-01
;23(
5
):1476-1490.
CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.
Ouadda ABD, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N
Oncotarget
2018-02-20
;9(
14
):11646-11664.
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.
Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP
Cancer Res.
2018-02-15
;.
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.
Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J
Mol. Cell
2017-07-13
;.
EPCR expression marks UM171-expanded CD34(+) cord blood stem cells.
Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G
Blood
2017-06-22
;129(
25
):3344-3351.
Actin cortex architecture regulates cell surface tension.
Chugh P, Clark AG, Smith MB, Cassani DAD, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch EK
Nat. Cell Biol.
2017-05-22
;.
Defining the role of the RSK isoforms in cancer.
Houles T, Roux PP
Semin. Cancer Biol.
2017-05-02
;.
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.
Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M
Nat Commun
2017-04-18
;8:15054.
Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling.
Zhang X, Lavoie G, Méant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP
Mol. Cell. Biol.
2017-04-01
;37(
7
):.
Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.
Laflamme C, Galan JA, Ben El Kadhi K, Méant A, Zeledon C, Carréno S, Roux PP, Emery G
Mol. Cell. Biol.
2017-02-01
;37(
3
):.
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.
Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok B, Roux PP, Hoang T
J. Clin. Invest.
2016-12-01
;126(
12
):4569-4584.
Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.
Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M
Proc. Natl. Acad. Sci. U.S.A.
2015-08-31
;.
Translational control by oncogenic signaling pathways.
Gao B, Roux PP
Biochim. Biophys. Acta
2015-07-01
;1849(
7
):753-765.
Effect of the transient pharmacological inhibition of mapk3/1 pathway on ovulation in mice.
Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi R
PLoS ONE
2015-03-24
;10(
3
):e0119387.
The expanding role of mTOR in cancer cell growth and proliferation.
Cargnello M, Tcherkezian J, Roux PP
Mutagenesis
2015-03-01
;30(
2
):169-176.
Regulation of global and specific mRNA translation by the mTOR signaling pathway.
Nandagopal N, Roux PP
Translation (Austin)
2015-02-02
;3(
1
):e983402.
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.
Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP
Proc. Natl. Acad. Sci. U.S.A.
2014-07-22
;111(
29
):E2918-27.
Cellular control of cortical actin nucleation.
Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, Charras G
Curr. Biol.
2014-07-21
;24(
14
):1628-35.
A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.
Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MG
Nat Commun
2014-07-17
;5:4431.
Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.
Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R
Mol. Reprod. Dev.
2014-07-01
;81(
7
):655-65.
Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness.
Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Décarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gérard X, Barcia G, Berquin P, Munnich A, Rouleau GA, Kaplan J, Rozet JM, Michaud JL
Am. J. Hum. Genet.
2014-06-05
;94(
6
):891-7.
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.
Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO
Oncogene
2014-04-01
;33(
13
):1690-9.
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5’TOP mRNA translation.
Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP
Genes Dev.
2014-02-15
;28(
4
):357-71.
Casein Kinase 1{varepsilon} Promotes Cell Proliferation by Regulating mRNA Translation.
Shin S, Wolgamott L, Roux PP, Yoon SO
Cancer Res.
2014-01-01
;74(
1
):201-11.
The Coming of Age of Phosphoproteomics–from Large Data Sets to Inference of Protein Functions.
Roux PP, Thibault P
Mol. Cell Proteomics
2013-12-01
;12(
12
):3453-64.
Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.
Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch EK
Cytoskeleton (Hoboken)
2013-11-01
;70(
11
):741-54.
Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly.
Capo-Chichi JM, Tcherkezian J, Hamdan FF, Décarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha BE, Major P, Shevell M, Bencheikh BO, Joober R, Samuels ME, Rouleau GA, Roux PP, Michaud JL
J. Med. Genet.
2013-11-01
;50(
11
):740-4.
Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism.
Smadja-Lamère N, Shum M, Déléris P, Roux PP, Abe J, Marette A
J. Biol. Chem.
2013-10-25
;288(
43
):31165-76.
Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers.
Yoon SO, Roux PP
Curr. Biol.
2013-10-07
;23(
19
):R880-3.
RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance.
Ray-David H, Romeo Y, Lavoie G, Déléris P, Tcherkezian J, Galan JA, Roux PP
Oncogene
2013-09-19
;32(
38
):4480-9.
Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression.
Wang P, Galan JA, Normandin K, Bonneil E, Hickson GR, Roux PP, Thibault P, Archambault V
J. Cell Biol.
2013-07-22
;202(
2
):277-93.
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden K, Meloche S, Roux PP
Oncogene
2013-06-13
;32(
24
):2917-26.
Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility.
Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carréno S, Roux PP
Mol. Cell. Biol.
2013-04-01
;33(
8
):1657-70.