The Histology platform covers the study and analysis of morphological and functional changes in tissues and provides a better understanding of cancer mechanisms. It enables the preservation of tissue samples taken from patients or animals through embedding (paraffin or OCT on frozen samples), sectioning, and staining. It also meets the needs for the preparation of cell pellets, tissue microarrays, and multi-tissue blocks, including formats compatible with spatial transcriptomics technologies (e.g., Xenium). The platform further offers single and multiplex staining services (immunohistochemistry and immunofluorescence), as well as support for DNA/RNA extraction from FFPE tissue samples. Finally, it offers the acquisition of complete images of microscope slides.
Services offered:
Preparation of paraffin-embedded samples
- Tissue fixation, paraffin embedding, microtome sectioning (onto charged or Xenium slides)
- Cell pellets
- Tissue microarrays (TMA) and multi-tissue blocks (adaptable to Xenium slides)
- Sectioning of FFPE samples into Eppendorf tubes for DNA/RNA extraction
Preparation of frozen samples
- Preparation of fresh or fixed tissue samples, OCT embedding, cryostat sectioning
Staining
- Routine staining (H&E, HPS)
- Special stains
- Immunohistochemistry (IHC) and immunofluorescence (IF)
- Multiplex IHC/IF
Digital imaging
- Digitization of clear field and fluorescence sections at 10, 20, and 40X
Other
- Histology consulting
Equipment:
- Leica CM3050SA cryostat
- Sakura Tissue Tek VIP6 circulator
- Leica RM2255 and Shandon Finesse E+ microtomes
- Sakura DRS601 stainer
- Leica Bond RX immunocolorator
- Sakura Tissue-Tek Glas slide mounters
- Beecher MTA-1 tissue chip preparation module
- Hamamatsu NanoZoomer 2.0-HT slide scanner (capacity 210 slides)
- Slide scanner + fluorescence (DAPI-AF488-AF555-AF647-AF750) Evident VS200 (capacity 60 slides)
Complete the form, save a PDF copy, print a paper copy that you’ll bring with your samples.