The In Vivo Biology platform provides cutting-edge scientific and technical expertise, as well as veterinary oversight for rodents, to support specialized research projects requiring murine models.

Preclinical research services (using mice and rats) encompass pharmacokinetic, biodistribution, and toxicology studies (maximum tolerated dose, repeated-dose studies), as well as oncology efficacy trials involving solid and hematological tumors. Expertise leverages xenograft, syngeneic, and humanized (PBMC/HSC) models to evaluate various therapeutic approaches, including small molecules, cell therapies, vaccines, and nanoparticles. Tailored support is also available for model development and protocol design.

The platform is equipped with state-of-the-art in vivo imaging systems for small animals. It features the OiS300 system (LabeoTech) for bioluminescence, epifluorescence, and transfluorescence imaging, as well as the multimodal SynIRgy system (Photon etc.), which offers high-resolution bioluminescence and near-infrared (NIR-I and NIR-II) imaging.

Colony management and transgenesis services ensure comprehensive care for animal models within a Specific Pathogen-Free (SPF) environment. Services include housing in ventilated cages, colony management, genotyping, importation, and user training. The transgenesis unit offers custom generation of genetically modified mice (via DNA injection, mutation induction, or stem cell technology), alongside services such as cryopreservation, in vitro fertilization, rederivation, and the generation of experimental cohorts.

Services offered:

Preclinical research services (mouse and rat)

• Pharmacokinetics and biodistribution studies
• Toxicology studies (maximum tolerated dose, repeated-dose)
• Efficacy studies in solid or non-solid (hematological) tumor models
• Xenograft models (immunodeficient mice) or syngeneic models
• Treatment with small molecules, cell therapy, vaccination, nanoparticles
• Generation of humanized mice (PBMC or HSC) for efficacy studies

• Research model development
  • Animal modeling
  • Design and generation of genetically modified mice and genotyping strategies
  • Consulting expertise for experimental protocol development
• Housing and colony management services
  • Housing in ventilated cages within a Specific Pathogen-Free (SPF) facility
  • Animal importation
  • Rodent colony management
  • Rodent genotyping
  • Administration techniques (IV, PO, IP, SC, etc.)
  • Anesthesia
  • Specialized surgeries
  • User training
  • Mouse irradiation

• Transgenesis services
  • Generation of genetically modified mice
  • Transgenic mice: DNA injection
  • Genetic modifications (insertion, deletion, specific mutations)
  • Embryonic stem cell microinjection
    Sperm or embryo cryopreservation
  • In vitro fertilization and rederivation
  • Generation of custom experimental cohorts