A bitter PP1 fights the sweet polo.

Publication

In a recent paper in Developmental Cell, Yamashiro et al. (2008) report that the PP1 regulatory subunit MYPT1 interacts with PLK1 and antagonizes essential mitotic functions of PLK1, at least in part by promoting the dephosphorylation of PLK1 at Thr210.

Publication date: juin 6, 2008
Principal Investigators: Archambault V, Chen F, Glover DM
PubMed reference: Mol. Cell 2008;30(5):541-2
PubMed ID: 18538650
Affiliation: Department of Genetics, Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Downing Street, CB2 3EH Cambridge, UK. va228@cam.ac.uk