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  • July 18, 2025

    Receptor Tyrosine Kinase Profiling Identifies Chronic Constitutive Floodgate Oxidative Signaling in Glutathione-Independent Human Mammary Luminal Progenitor Cells.

    Aalam SMM, Ritting ML, Ps H, Shi GX, Shih K, Dong Y, Kalthur G, Miao C, Yu Y, Knapp D, Eirew P, Pellacani D, Emperumal CP, Wang H, Janus JR, Sherman ME, Goetz MP, McLaughlin SA, Boughey JC, Degnim AC, Zeng H, Pandey A, Radisky DC, Sadanandam A, Kannan N
    bioRxiv 2025-07-18 ;

  • July 17, 2025

    Modeling RNA duplex dynamics with Gibbs sampling enhances base-pair prediction accuracy and reveals structural activity profiles.

    Chasles S, Major F
    NAR Genom Bioinform 2025-07-17 ;7( 3 ):lqaf099

  • July 1, 2025

    O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis.

    Ahmed O, Masclef L, Iannantuono N, Gagnon J, Gushul-Leclaire M, Boulay K, Estavoyer B, Echbicheb M, Ali Boubacar K, Poy M, Boubekeur A, Menggad S, Schcolnik-Cabrera A, Balsalobre A, Bonneil E, Thibault P, Hulea L, Mallette FA, Drouin J, Tanaka Y, Affar EB
    Nat Commun 2025-07-01 ;16( 1 ):5959

  • June 30, 2025

    Posttranscriptional activity of eIF4E contributes to HoxA9-driven leukemogenesis.

    Zhou F, Culjkovic-Kraljacic B, Bach C, Feng L, Mishima Y, Borden K, Tenen DG
    Blood Neoplasia 2025-06-30 ;2( 4 ):100132

  • June 30, 2025

    Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.

    Jayashankar V, Kubiniok P, McCracken AN, Gentry RG, Eckenstein KH, Sernissi L, Vece V, Garsi JB, Valles SY, Jung S, Hoffman NC, Perrochon AS, Selwan EM, Finicle BT, Pitman M, Lin D, Bonneil E, Xu R, Mao C, Kaiser P, Fruman DA, Mobley D, Jang C, Hanessian S, Thibault P, Edinger AL
    EMBO J 2025-06-30 ;

  • June 18, 2025

    Gender representation in professorship and research productivity across all surgical specialties in Canadian academic institutions.

    Tanya SM, Nguyen AX, Joly-Chevrier M, Pur DR, Sharma S, Costello F, Kherani F, Trinh VQ, Hardy I, Lando L
    Can J Surg 2025-06-18 ;68( 3 ):E253-E264

  • June 12, 2025

    CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity.

    Rodriguez MM, Chatterjee D, Guerry J, Patenaude AM, Cohen CCH, Bois T, Larouche A, Ferreira SR, Bertomeu T, Chatr-Aryamontri A, Zhang L, Mader S, Nislow C, St-Jean G, Guindon Y, Zahn A, Di Noia JM
    Proc Natl Acad Sci U S A 2025-06-12 ;122( 24 ):e2424409122

  • June 11, 2025

    Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R.

    Morales-Pastor A, Miljuš T, Dieguez-Eceolaza M, Stępniewski TM, Ledesma-Martin V, Heydenreich FM, Flock T, Plouffe B, Le Gouill C, Duchaine J, Sykes DA, Nicholson C, Koers EJ, Guba W, Rufer AC, Grether U, Bouvier M, Veprintsev DB, Selent J
    Nat Commun 2025-06-11 ;16( 1 ):5265

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