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  • July 1, 2019

    Agonist-induced desensitisation of β -adrenoceptors: Where, when, and how?

    Okeke K, Angers S, Bouvier M, Michel MC
    Br. J. Pharmacol. 2019-07-01 ;176( 14 ):2539-2558

  • June 30, 2019

    Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.

    Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN
    ACS Omega 2019-06-30 ;4( 6 ):10056-10069

  • June 25, 2019

    Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.

    Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GY
    Proc. Natl. Acad. Sci. U.S.A. 2019-06-25 ;116( 26 ):13006-13015

  • June 21, 2019

    Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.

    Killoran RC, Smith M
    J. Biol. Chem. 2019-06-21 ;294( 25 ):9937-9948

  • June 13, 2019

    Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.

    Da Costa EM, Armaos G, McInnes G, Beaudry A, Moquin-Beaudry G, Bertrand-Lehouillier V, Caron M, Richer C, St-Onge P, Johnson JR, Krogan N, Sai Y, Downey M, Rafei M, Boileau M, Eppert K, Flores-Díaz E, Haman A, Hoang T, Sinnett D, Beauséjour C, McGraw S, Raynal NJ
    J. Exp. Clin. Cancer Res. 2019-06-13 ;38( 1 ):251

  • June 10, 2019

    Addendum: Precise tuning of gene expression levels in mammalian cells.

    Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp D, Milne TA, Cerundolo V, Fulga TA
    Nat Commun 2019-06-10 ;10( 1 ):2622

  • June 1, 2019

    Pediatric leukemia: Moving toward more accurate models.

    Milan T, Canaj H, Villeneuve C, Ghosh A, Barabé F, Cellot S, Wilhelm B
    Exp. Hematol. 2019-06-01 ;74:1-12

  • May 28, 2019

    Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.

    Belmonte FR, Dedousis N, Sipula I, Desai NA, Singhi AD, Chu Y, Zhang Y, Bannwarth S, Paquis-Flucklinger V, Harrington L, Shiva S, Jurczak MJ, O'Doherty RM, Kaufman BA
    PLoS ONE 2019-05-28 ;14( 5 ):e0203101

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