305 results
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.
Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA
Nat Commun
2021-08-03
;12(
1
):4688.
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.
García RA, Lupisella JA, Ito BR, Hsu MY, Fernando G, Carson NL, Allocco JJ, Ryan CS, Zhang R, Wang Z, Heroux M, Carrier M, St-Onge S, Bouvier M, Dudhgaonkar S, Nagar J, Bustamante-Pozo MM, Garate-Carrillo A, Chen J, Ma X, Search DJ, Dierks EA, Kick EK, Wexler RR, Gordon DA, Ostrowski J, Wurtz NR, Villarreal F
JACC Basic Transl Sci
2021-08-01
;6(
8
):676-689.
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs.
Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F
Cell Res
2021-07-08
;.
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.
Trauelsen M, Hiron TK, Lin D, Petersen JE, Breton B, Husted AS, Hjorth SA, Inoue A, Frimurer TM, Bouvier M, O'Callaghan CA, Schwartz TW
Cell Rep
2021-06-15
;35(
11
):109246.
Bioluminescence Resonance Energy Transfer (BRET) Imaging in Living Cells: Image Acquisition and Quantification.
Kobayashi H, Bouvier M
Methods Mol Biol
2021-05-29
;2274:305-314.
Illuminating the complexity of GPCR pathway selectivity - advances in biosensor development.
Wright SC, Bouvier M
Curr Opin Struct Biol
2021-05-25
;69:142-149.
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes.
Wright SC, Lukasheva V, Le Gouill C, Kobayashi H, Breton B, Mailhot-Larouche S, Blondel-Tepaz E, Antunes Vieira N, Costa-Neto C, Héroux M, Lambert NA, Parreiras-E-Silva LT, Bouvier M
Proc Natl Acad Sci U S A
2021-05-18
;118(
20
):.
Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.
Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault E
J Med Chem
2021-05-13
;64(
9
):5345-5364.
Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7.
Meyrath M, Palmer CB, Reynders N, Vanderplasschen A, Ollert M, Bouvier M, Szpakowska M, Chevigné A
ACS Pharmacol Transl Sci
2021-04-09
;4(
2
):813-823.
Development of conformational BRET biosensors that monitor ezrin, radixin and moesin activation in real time.
Leguay K, Decelle B, He YY, Pagniez A, Hogue M, Kobayashi H, Le Gouill C, Bouvier M, Carréno S
J Cell Sci
2021-04-01
;134(
7
):.
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J
Cell Rep
2021-03-23
;34(
12
):108862.
Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.
Grunddal KV, Diep TA, Petersen N, Tough IR, Skov LJ, Liu L, Buijink JA, Mende F, Jin C, Jepsen SL, Sørensen LME, Achiam MP, Strandby RB, Bach A, Hartmann B, Frimurer TM, Hjorth SA, Bouvier M, Cox H, Holst B
Mol Metab
2021-03-09
;101207.
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.
Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, Crain E, St-Onge S, Héroux M, Bouvier M, Xu C, Chen XQ, Generaux C, Lawrence M, Wexler R, Gordon D
Circ Heart Fail
2021-03-01
;14(
3
):e007351.
The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.
Blondel-Tepaz E, Leverve M, Sokrat B, Paradis JS, Kosic M, Saha K, Auffray C, Lima-Fernandes E, Zamborlini A, Poupon A, Gaboury L, Findlay J, Baillie GS, Enslen H, Bouvier M, Angers S, Marullo S, Scott MGH
Oncogene
2021-03-01
;40(
12
):2243-2257.
Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.
René P, Lanfray D, Richard D, Bouvier M
JCI Insight
2021-02-22
;6(
4
):.
Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish.
Tschaikner PM, Regele D, Röck R, Salvenmoser W, Meyer D, Bouvier M, Geley S, Stefan E, Aanstad P
Development
2021-02-17
;148(
4
):.
Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.
Trân K, Murza A, Sainsily X, Delile E, Couvineau P, Côté J, Coquerel D, Peloquin M, Auger-Messier M, Bouvier M, Lesur O, Sarret P, Marsault E
J Med Chem
2021-01-14
;64(
1
):602-615.
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.
Latorraca NR, Masureel M, Hollingsworth SA, Heydenreich FM, Suomivuori CM, Brinton C, Townshend RJL, Bouvier M, Kobilka BK, Dror RO
Cell
2020-12-23
;183(
7
):1813-1825.e18.
Signal Transduction Profiling of Angiotensin II Type 1 Receptor With Mutations Associated to Atrial Fibrillation in Humans.
Simões SC, Balico-Silva AL, Parreiras-E-Silva LT, Bitencourt ALB, Bouvier M, Costa-Neto CM
Front Pharmacol
2020-12-22
;11:600132.
Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H3 and H4 receptors.
Corrêa MF, Balico-Silva AL, Kiss DJ, Fernandes GAB, Maraschin JC, Parreiras-E-Silva LT, Varela MT, Simões SC, Bouvier M, Keserű GM, Costa-Neto CM, Fernandes JPS
Bioorg Med Chem
2020-12-08
;30:115924.
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis.
Sundqvist M, Holdfeldt A, Wright SC, Møller TC, Siaw E, Jennbacken K, Franzyk H, Bouvier M, Dahlgren C, Forsman H
Biochim Biophys Acta Mol Cell Res
2020-12-01
;1867(
12
):118849.
Beta-arrestins operate an on/off control switch for focal adhesion kinase activity.
Alexander RA, Lot I, Saha K, Abadie G, Lambert M, Decosta E, Kobayashi H, Beautrait A, Borrull A, Asnacios A, Bouvier M, Scott MGH, Marullo S, Enslen H
Cell Mol Life Sci
2020-12-01
;77(
24
):5259-5279.
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects.
Avet C, Sturino C, Grastilleur S, Le Gouill C, Semache M, Gross F, Gendron L, Bennani Y, Mancini JA, Sayegh CE, Bouvier M
Commun Biol
2020-11-27
;3(
1
):719.
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.
Møller TC, Pedersen MF, van Senten JR, Seiersen SD, Mathiesen JM, Bouvier M, Bräuner-Osborne H
Sci Rep
2020-10-15
;10(
1
):17395.
Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study.
Imam A, Winnebeck EC, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter C
Front Physiol
2020-10-09
;11:564140.
Agonist-induced formation of unproductive receptor-G12 complexes.
Okashah N, Wright SC, Kawakami K, Mathiasen S, Zhou J, Lu S, Javitch JA, Inoue A, Bouvier M, Lambert NA
Proc Natl Acad Sci U S A
2020-09-01
;117(
35
):21723-21730.
Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein-coupled receptors.
Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Sokrat B, Sposini S, Chaturvedi M, Srivastava A, Roy D, Hanyaloglu AC, Bouvier M, Shukla AK
J. Biol. Chem.
2020-07-24
;295(
30
):10153-10167.
Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.
Lukasheva V, Devost D, Le Gouill C, Namkung Y, Martin RD, Longpré JM, Amraei M, Shinjo Y, Hogue M, Lagacé M, Breton B, Aoki J, Tanny JC, Laporte SA, Pineyro G, Inoue A, Bouvier M, Hébert TE
Sci Rep
2020-05-29
;10(
1
):8779.
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carréno S, Roux PP
Cell Rep
2020-05-19
;31(
7
):107660.
Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin.
Picard LP, Schonegge AM, Bouvier M
ACS Pharmacol Transl Sci
2020-04-09
;2(
3
):148-154.
Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment.
García RA, Ito BR, Lupisella JA, Carson NA, Hsu MY, Fernando G, Heroux M, Bouvier M, Dierks E, Kick EK, Gordon DA, Chen J, Mintier G, Carrier M, St-Onge S, Shah H, Towne J, Bucardo MS, Ma X, Ryan CS, Wurtz NR, Ostrowski J, Villarreal FJ
JACC Basic Transl Sci
2020-01-09
;4(
8
):905-920.
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, Lichtarge O, Schmidt A, Bouvier M, Pineyro G
Nat Commun
2019-09-09
;10(
1
):4075.
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.
Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A
J. Med. Chem.
2019-08-22
;62(
16
):7400-7416.
Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.
Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne H
Neuropharmacology
2019-07-24
;107718.
Agonist-induced desensitisation of β -adrenoceptors: Where, when, and how?
Okeke K, Angers S, Bouvier M, Michel MC
Br. J. Pharmacol.
2019-07-01
;176(
14
):2539-2558.
Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.
Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GY
Proc. Natl. Acad. Sci. U.S.A.
2019-06-25
;116(
26
):13006-13015.
Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias.
Stanek M, Picard LP, Schmidt MF, Kaindl JM, Hübner H, Bouvier M, Weikert D, Gmeiner P
J. Med. Chem.
2019-05-23
;62(
10
):5111-5131.
Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G
Nat. Chem. Biol.
2019-05-01
;15(
5
):489-498.
Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells.
Kobayashi H, Picard LP, Schönegge AM, Bouvier M
Nat Protoc
2019-04-01
;14(
4
):1084-1107.
Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.
Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL
iScience
2019-03-15
;14:47-57.
FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.
Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C
Sci Signal
2018-12-04
;11(
559
):.
Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.
Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA
Sci Signal
2018-12-04
;11(
559
):.
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.
Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK
Nat. Chem. Biol.
2018-11-01
;14(
11
):1059-1066.
Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.
Hamoud N, Tran V, Aimi T, Kakegawa W, Lahaie S, Thibault MP, Pelletier A, Wong GW, Kim IS, Kania A, Yuzaki M, Bouvier M, Côté JF
Nat Commun
2018-10-26
;9(
1
):4470.
Translating biased signaling in the ghrelin receptor system into differential in vivo functions.
Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst B
Proc. Natl. Acad. Sci. U.S.A.
2018-10-23
;115(
43
):E10255-E10264.
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.
Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ
Sci Signal
2018-09-25
;11(
549
):.
Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling.
Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume JL, Hegron A, Boissel M, Canouil M, Langenberg C, Wareham NJ, Le Gouill C, Lukasheva V, Lichtarge O, Froguel P, Bouvier M, Jockers R
Sci Signal
2018-08-28
;11(
545
):.
Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes.
Picard LP, Schönegge AM, Lohse MJ, Bouvier M
Commun Biol
2018-08-07
;1:106.
Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways.
Young M, Dahoun T, Sokrat B, Arber C, Chen KM, Bouvier M, Barth P
Proc. Natl. Acad. Sci. U.S.A.
2018-07-03
;115(
27
):7051-7056.
Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.
Chaturvedi M, Schilling J, Beautrait A, Bouvier M, Benovic JL, Shukla AK
Trends Biochem. Sci.
2018-07-01
;43(
7
):533-546.