Training
Ph.D. in Molecular Biology
option Systems Biology
Program description
The program offers Ph.D. training in molecular biology, systems biology option, from the Université de Montréal.
The Ph.D. Program in Molecular Biology, Systems Biology option, offers you the opportunity to lead a research project by adopting a multidisciplinary approach that integrates, in the context of fundamental and translational cancer research, molecular biology, cell biology, biochemistry, immunology, bioinformatics, genomics, medical physics, and the more clinical aspects of biomedical research.
This top-notch training is aimed at creating strong scientists with varied expertise who can act as leaders in expanding the frontiers of knowledge in this very vast area.
Structure
Lasting approximately 5 years, this program enables you to acquire the concepts and the practice of systems biology, while remaining focused on fundamental or translational research. This training prepares you for meeting the challenge of operating at the interface of several complementary disciplines in order to study complex questions related to multigenetic diseases.
The courses must be taken during the first two years of the Ph.D. program.
BIM7021A, B, C, D – Lectures in Cancer Biology (3 elective courses)
Through a series of weekly lectures given by internationally renowned Investigators from various fields of biomedical research, these courses aim to 1) expose you to different techniques and experimental systems in molecular, cell and structural biology, 2) improve your ability to understand and summarize research results presented in scientific articles and seminars, 3) exercise your critical judgment with respect to results and conclusions presented in scientific articles and seminars, and 4) improve your scientific communication skills.
BIM6070 – Professional Practice of Research
This course is an introduction to the scientific method in research and to the experimental approach. Furthermore, this course initiates you to the scientific critical review process, to the writing of a scientific article, to the writing of a research project and to the preparation of a grant proposal. This course also encourages you to think about the ethical issues involved with biomedical research by encouraging you to identify and discuss the ethical questions and matters that may arise. Finally, guest speakers present you with some career possibilities related to biomedical research.
BIM7015 – Research Seminar
As part of this course, you will present, in the form of a 40-minute seminar, your Ph.D. research project. This course is aimed at teaching you methods to summarize your research work, to make an oral presentation of the results and to discuss the project.
Summer School in Systems Biology
Students wishing to complete their training may also take several courses offered as part of the Summer School in Systems Biology.
The Summer School in Systems Biology offers a series of theoretical and practical courses unique to the Institute and available for Master’s and Ph.D. programs in systems biology. Its particularity is that it is centered around IRIC’s students and that it is ensured by the Institute’s Investigators.
The courses are subdivided into two categories: theoretical courses involving topics related to fundamental and translational cancer research and laboratory courses that will enable you to put the knowledge acquired into practice.
Through its rich and dynamic programming, the Summer School makes it possible to put directly into practice the knowledge passed along by distinguished Investigators, to develop autonomy in the laboratory and to become familiar with the scientific equipment and resources offered at IRIC. As a result, you can begin or continue your research activities with confidence. A good knowledge of English is required to attend to Summer School.
Summer School - Theoretical courses
The theoretical courses cover a variety of topics related to the cell and molecular biology of cancer, the molecular genetics of eukaryotes, immuno-oncology, model organisms and experimental approaches based on systems biology such as biophysics, nanotechnologies, proteomics, etc.
BIM6064A – Cellular and Molecular Biology of Cancer (required)
The BIM6064A course offers theoretical training in cellular and molecular cancer research making it possible to understand the mechanisms of gene expression and cell cycle control by signalling pathways and their dysregulation in cancer. This course includes the following presentations:
- Gene expression: Epigenetic regulation and cancer (by Julie Lessard)
- Gene expression: Transcriptional regulation and cancer (by Sylvie Mader)
- Perspective & Challenges of Deciphering the Long noncoding RNAs Grammar (by Martin Sauvageau)
- Molecular Biology of the Cell (by Gregory Emery)
- Signalling pathways (by Gregory Emery)
- Cell Cycle: Signalling and cell cycle progression (by Sylvain Meloche)
- Clonal evolution in cancer and stress mitigation pathways (by Trang Hoang)
BIM6064C – Approaches in Systems Biology (required)
The BIM6064C course offers theoretical training on system biology approaches for the analysis of cell signalling and molecular genetics. It makes it possible to know the approaches in systems biology and their contribution to the advancement of knowledge in cancer biology and molecular genetics. This course includes the following presentations:
- How to write a scholarship application (by Philippe Roux).
- Post-translational modifications (by Philippe Roux)
- Proteomics (by Pierre Thibault)
- Genetic screens (by Vincent Archambault)
- Functional approaches by loss of function (by David Knapp)
- Nanotechnology in biology (by Delphine Bouilly)
BIM6064D - Immuno-oncology: From the Laboratory to the Clinic (required)
The BIM6064D course offers theoretical training on therapeutic targeting, drug development, clinical research in leukemia and breast cancer, the use of stem cells in cancer therapy, and immunotherapy. It makes it possible to acquire basic concepts in immunology and oncology and presents various examples of applications of laboratory research in the clinical and drug discovery fields. In addition to the visit of IRIC’s Histology and High-Throughput Screening Core Facilities, this course includes the following theoretical presentations:
- Cellular heterogeneity in oncogenesis and treatment response (by David Knapp)
- Stem cells and cancer treatment (by Guy Sauvageau)
- Malignant hemopathies (by I. Ahmad)
- General concepts of immunology and antigen presentation (by Claude Perreault)
- The use of Drosophila in cancer research (by Marc Therrien)
- How to set up clinical trials in cell therapy (by Denis-Claude Roy)
- Function of T cell and cancer immunotherapy (by Etienne Gagnon)
- C. elegans genetics and small molecule screening (by Jean-Claude Labbé)
- Chromosomal aberrations/Laboratory tests in clinical hematology (by Josée Hébert)
- Study of the immunopeptidome by mass spectrometry (by Isabelle Sirois)
- Therapeutic development in breast cancer (by Geneviève Deblois)
- Zebrafish as a model system for drug development (by Ruben Marin Juez)
Summer School - Practical courses
Laboratory courses present various techniques related to molecular biology, cell analysis, protein expression and purification, analysis of the biochemical and biophysical properties of proteins, functional genomics, bioinformatics and the use of model organisms. During these practical courses, you carry out several research projects requiring the use of IRIC’s core facilities.
BIM6065A – Practice in Molecular Biology (required)
The BIM6065A course offers laboratory training and its goal is to teach basic techniques in molecular biology in order for them to be used simply, quickly and effectively. Its main objectives are hands-on training involving in vivo-directed mutagenesis, DNA sequencing and bioinformatics techniques and gene-targeting approaches by Gibson assembly and CrispR-Cas9 technologies.
BIM6065C – Bioinformatics Analysis (required)
The BIM6065C course offers theoretical and practical training in bioinformatics analysis and its goal is to familiarize you with 1) databases, 2) network analysis techniques, and 3) modelling of the structure of macromolecules. It includes theoretical presentations and tutorials leading to various assignments.
BIM6065D – Functional Genomics (required)
The BIM6065D course offers theoretical and practical training in functional genomics, DNA microarrays, gene expression analysis and large-scale chromatin immunoprecipitation. Its goal is to teach you 1) high-throughput sequencing techniques, and 2) DNA microarray hybridization techniques, data analysis, and the analysis of large-scale chromatin immunoprecipitation. This course includes theoretical presentations and practical work leading to various assignments.
BIM6065E – Biochemistry of Proteins (required)
The BIM6065E course offers practical laboratory training in the field of biochemistry of proteins. It follows course BIM6065A and its goal is to teach you 1) techniques to express and purify proteins (FPLC chromatography) and 2) techniques to study the chemical and biophysical properties of proteins (mass spectrometry, circular dichroism and ultracentrifugation). This course includes practical work using IRIC’s Proteomics and Biophysics Core Facilities, theoretical presentations, group discussions and written assignments.
A Université de Montréal program
This collaborative program allows you to benefit from not only the expertise and support of over thirty professors, Investigators and scientific professionals from IRIC, but also of Investigators from various departments of the Université de Montréal, the CHUM Research Centre (CRCHUM) and the Maisonneuve-Rosemont Hospital Research Centre (CRHMR).
Why study at IRIC?
To study at IRIC is to gain access to unique and personalized guidance, a team of experts in fundamental, translational and applied research, as well as state-of-the-art infrastructures that make it possible to optimize cancer research efforts.