Principal Investigator

Brian Wilhelm

High-Throughput Genomics

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Brian Wilhelm earned his Ph.D. in medical genetics from UBC at the Terry Fox Laboratory in Vancouver in 2003. He pursued postdoctoral training at the Wellcome Trust Sanger Institute in the United Kingdom in Dr. Jurg Bahler’s functional genomics lab, and then in Dr. Guy Sauvageau’s laboratory at IRIC, focusing on leukemia biology.

In 2010, Brian Wilhelm launched his laboratory, the Institute’s High-Throughput Genomics Research Unit, and began teaching as a professor in the Department of Medicine at the Université de Montréal.

Brian Wilhelm’s research team uses the latest high-throughput technologies, such as next-generation DNA sequencing (e.g., RNA-seq, Cut-and-Run, ATAC-seq), and genome-wide CRISPR chemogenomic screens to elucidate the connections between transcriptional activity and the biology of pediatric leukemia.

Principal Investigator, High-Throughput Genomics Research Unit, IRIC
Genomics Core Facility Scientific Director

Associate Professor, Department of Medicine, Faculty of Medicine, Université de Montréal

Research unit on high-throughput genomics

Marcelle-Coutu Pavilion, 4306-13

Phone (office)
(514) 343-6111, ext. 0923
Fax
(514) 343-7780
Email
brian.wilhelm@umontreal.ca
Apply for a M.Sc. or a Ph.D.

High-Throughput Genomics

Brian Wilhelm’s research team uses the latest high-throughput technologies, such as next-generation DNA sequencing (e.g., RNA-seq, Cut-and-Run, ATAC-seq), and genome-wide CRISPR chemogenomic screens to elucidate the connections between transcriptional activity and the biology of pediatric leukemia.

Discover the research unit View the research team

Research topics

Publications

  • January 30, 2026

    A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

    Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden K, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M
    bioRxiv 2026-01-30 ;

  • September 8, 2025

    The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility.

    Arman K, Ross J, Piskor EM, Lazzari L, Calderon V, Reulet G, Vera M, St Hilaire E, Wurtele H, Wilhelm B, Möröy T
    Blood Adv 2025-09-08 ;

  • October 29, 2024

    Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines.

    Safa-Tahar-Henni S, Páez Martinez K, Gress V, Esparza N, Roques E, Bonnet-Magnaval F, Bilodeau M, Gagné V, Bresson E, Cardin S, El-Hachem N, Iasenza I, Alzial G, Boivin I, Nakamichi N, Soufflet AC, Mirela Pascariu C, Duchaine J, Mathien S, Bonneil E, Eppert K, Marinier A, Sauvageau G, Deblois G, Thibault P, Hébert J, Eaves CJ, Cellot S, Barabé F, Wilhelm B
    Leukemia 2024-10-29 ;39( 1 ):29-41

  • September 20, 2023

    CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216.

    Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard E, Thibault P, Bonneil E, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith M, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm B, Cellot S
    Blood Adv 2023-09-20 ;

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Awards and distinctions

  • Career scholarship Junior 1, Le Fonds de recherche du Québec, 2016-2020

  • Career scholarship Junior 2, Le Fonds de recherche du Québec, 2012-2016

  • Career transition scholarship, Cole Foundation, 2010-2013

  • Fellowship, Cole Foundation, 2009-2011

  • Fellowship, Wellcome Trust Sanger Institute, 2004-2006

  • Fellowship, National Sciences and Engineering Research Council of Canada, 2000-2002

  • Doctoral Award, Michael Smith Foundation for Health Research, 2001-2003

  • Doctoral Award, National Sciences and Engineering Research Council of Canada, 2000-2002

  • University Graduate Fellowship, University of British Columbia, 1999-2000

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