Guy Sauvageau, M.D., Ph.D., F.R.C.P.(C)
- Principal Investigator, Molecular Genetics of Stem Cells research unit, IRIC
- Professor, Department of Medicine, Faculty of Medicine, Université de Montréal
- Adjunct Professor, Department of Experimental Medicine, McGill University
- Hematologist, Stem Cell Transplant Centre, Department of Hematology, Maisonneuve-Rosemont Hospital
- Scientific Advisor, Quebec Leukemia Cell Bank
Research topic and relevance
Guy Sauvageau and his team study the molecular basis for self-renewal, a central process in the regulation of stem cells, whether normal cells or cancerous (as in leukemia). Specifically, they focus their research on two families of genes that are dysregulated in leukemia, the HOXB4 and Bmi1 genes. These genes are instrumental in the self-renewal of normal cells. The research aims to develop more effective gene-based therapeutic approaches to treat cancer.