Research field

Immunology & Hematopoiesis

Understanding the protective role of the immune system against cancers and development of immuno-therapeutic approaches. Characterization of the blood stem cells and their derivatives and study of the genesis of hematological cancers.

Principal Investigators

  • Katherine Borden

    Structure and Function of the Cell Nucleus

  • Trang Hoang

    Hematopoiesis and Leukemia

  • Julie Lessard

    Chromatin Structure and Stem Cell Biology

  • Philippe P. Roux

    Cell Signaling and Proteomics

  • Guy Sauvageau

    Molecular Genetics of Stem Cells

  • Brian Wilhelm

    High-Throughput Genomics

Publications

  • January 1, 2022

    Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.

    Milan T, Celton M, Lagacé K, Roques E, Safa-Tahar-Henni S, Bresson E, Bergeron A, Hebert J, Meshinchi S, Cellot S, Barabé F, Wilhelm B
    Haematologica 2022-01-01 ;107( 1 ):86-99.

  • December 31, 2021

    MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy.

    Possamaï D, Hanafi LA, Bellemare-Pelletier A, Hamelin K, Thébault P, Hébert MJ, Gagnon E, Leclerc D, Lapointe R
    PLoS One 2021-12-31 ;16( 12 ):e0261987.

  • December 23, 2021

    HLF expression defines the human hematopoietic stem cell state.

    Lehnertz B, Chagraoui J, MacRae T, Tomellini E, Corneau S, Mayotte N, Boivin I, Durand A, Gracias D, Sauvageau G
    Blood 2021-12-23 ;138( 25 ):2642-2654.

  • See all publications