Research field

Immunology & Hematopoiesis

Understanding the protective role of the immune system against cancers and development of immuno-therapeutic approaches. Characterization of the blood stem cells and their derivatives and study of the genesis of hematological cancers.

Principal Investigators

  • Katherine Borden

    Structure and Function of the Cell Nucleus

  • Trang Hoang

    Hematopoiesis and Leukemia

  • Julie Lessard

    Chromatin Structure and Stem Cell Biology

  • Philippe P. Roux

    Cell Signaling and Proteomics

  • Guy Sauvageau

    Molecular Genetics of Stem Cells

  • Brian Wilhelm

    High-Throughput Genomics

Publications

  • septembre 13, 2022

    Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.

    Lisi V, Blanchard E, Vladovsky M, Audemard E, Ferghaly A, Lemieux S, Hébert J, Sauvageau G, Lavallée VP
    Blood Adv 2022-09-13 ;6( 17 ):5160-5164.

  • septembre 1, 2022

    DNA barcoded competitive clone-initiating cell analysis reveals novel features of metastatic growth in a cancer xenograft model.

    Aalam SMM, Tang X, Song J, Ray U, Russell SJ, Weroha SJ, Bakkum-Gamez J, Shridhar V, Sherman ME, Eaves CJ, Knapp D, Kalari KR, Kannan N
    NAR Cancer 2022-09-01 ;4( 3 ):zcac022.

  • août 26, 2022

    DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells.

    Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, Durland LJ, Knapp D, Zandstra PW
    Sci Adv 2022-08-26 ;8( 34 ):eabn5522.

  • See all publications