Research field

Immunology & Hematopoiesis

Understanding the protective role of the immune system against cancers and development of immuno-therapeutic approaches. Characterization of the blood stem cells and their derivatives and study of the genesis of hematological cancers.

Principal Investigators

  • Katherine Borden

    Structure and Function of the Cell Nucleus

  • Trang Hoang

    Hematopoiesis and Leukemia

  • Julie Lessard

    Chromatin Structure and Stem Cell Biology

  • Philippe P. Roux

    Cell Signaling and Proteomics

  • Guy Sauvageau

    Molecular Genetics of Stem Cells

  • Brian Wilhelm

    High-Throughput Genomics

Publications

  • November 11, 2019

    Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.

    Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok B, Borden K
    Proc. Natl. Acad. Sci. U.S.A. 2019-11-11 ;.

  • November 5, 2019

    Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.

    Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G
    Lancet Haematol 2019-11-05 ;.

  • October 1, 2019

    Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children.

    de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL
    Genes Chromosomes Cancer 2019-10-01 ;58( 10 ):723-730.

  • See all publications