Research field

Immunology & Hematopoiesis

Understanding the protective role of the immune system against cancers and development of immuno-therapeutic approaches. Characterization of the blood stem cells and their derivatives and study of the genesis of hematological cancers.

Principal Investigators

  • Katherine Borden

    Structure and Function of the Cell Nucleus

  • Trang Hoang

    Hematopoiesis and Leukemia

  • Julie Lessard

    Chromatin Structure and Stem Cell Biology

  • Philippe P. Roux

    Cell Signaling and Proteomics

  • Guy Sauvageau

    Molecular Genetics of Stem Cells

  • Brian Wilhelm

    High-Throughput Genomics

Publications

  • March 23, 2021

    TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.

    Connolly A, Panes R, Tual M, Lafortune R, Bellemare-Pelletier A, Gagnon E
    Sci Signal 2021-03-23 ;14( 675 ):.

  • March 16, 2021

    Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.

    Moison C, Chagraoui J, Caron MC, Gagné JP, Coulombe Y, Poirier GG, Masson JY, Sauvageau G
    Proc Natl Acad Sci U S A 2021-03-16 ;118( 11 ):.

  • March 15, 2021

    Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.

    Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault C
    Immunity 2021-03-15 ;.

  • See all publications