Publications

H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations.Lehnertz B, Zhang YW, Boivin I, Mayotte N, Tomellini E, Chagraoui J, Lavallée VP, Hébert J, Sauvageau GBlood 2017-11-16;130(20):2204-2214.

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau GClin. Cancer Res. 2017-11-15;23(22):6969-6981.

UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.Aucagne R, Girard S, Mayotte N, Lehnertz B, Lopes-Paciencia S, Gendron P, Boucher G, Chagraoui J, Sauvageau GFASEB J. 2017-11-01;31(11):5012-5018.

MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau GNucleic Acids Res. 2017-07-27;45(13):e122.

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow CNat. Cell Biol. 2017-07-01;19(7):844-855.

EPCR expression marks UM171-expanded CD34(+) cord blood stem cells.Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau GBlood 2017-06-22;129(25):3344-3351.

SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism.Priam P, Krasteva V, Rousseau P, D'Angelo G, Gaboury L, Sauvageau G, Lessard JANat. Genet. 2017-05-01;49(5):753-764.

Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?Richard-Carpentier G, Sauvageau GCell Stem Cell 2017-03-02;20(3):300-301.

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau GBlood Cancer J 2017-02-17;7(2):e529.

Distinct signaling programs control human hematopoietic stem cell survival and proliferation.Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJBlood 2017-01-19;129(3):307-318.

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