Principal Investigator

Matthew Smith

Cancer Signalling and Structural Biology

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After obtaining his Ph.D. in Molecular and Medical Genetics at the University of Toronto, Dr. Matthew Smith carried out a postdoctoral fellowship in the Medical Biophysics Department of the Ontario Cancer Institute.

He joined IRIC in December of 2015 as a Principal Investigator in the Cancer Signalling and Structural Biology Research Unit. He holds a position of Research Associate Professor in the Department of Pathology and Cell Biology at the Université de Montréal’s Faculty of Medicine, and a Tier II Canada Research Chair in Cancer Signalling and Structural Biology.

Principal Investigator, Cancer Signalling and Structural Biology Research Unit, IRIC

Associate Professor, Department of Pathology and Cell Biology, Université de Montréal

Cancer Signalling and Structural Biology Research Unit

Marcelle-Coutu Pavilion, 4306-11

Phone (office)
(514) 343-5704
Fax
(514) 343-7780
Email
matthew.james.smith@umontreal.ca
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Cancer Signalling and Structural Biology

The research carried out by Matthew J. Smith and his team aims to integrate modern experimental approaches in structural biology, biophysics, evolutionary bioinformatics and cell biology to help identify and understand both normal and disrupted cell signalling at a mechanistic and systems level.

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Research topics

Publications

  • September 20, 2023

    CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216.

    Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard E, Thibault P, Bonneil E, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith M, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm B, Cellot S
    Blood Adv 2023-09-20 ;

  • August 1, 2023

    Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

    Elkholi IE, Boulais J, Thibault MP, Phan HD, Robert A, Lai LB, Faubert D, Smith M, Gopalan V, Côté JF
    J Biol Chem 2023-08-01 ;105123

  • July 4, 2023

    Defining bone fide effectors of RAS GTPases.

    Smith M
    Bioessays 2023-07-04 ;e2300088

  • November 18, 2022

    Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.

    Tran V, Nahlé S, Robert A, Desanlis I, Killoran R, Ehresmann S, Thibault MP, Barford D, Ravichandran KS, Sauvageau M, Smith M, Kmita M, Côté JF
    Nat Commun 2022-11-18 ;13( 1 ):7077

  • See all publications

Awards and distinctions

  • Tier 2 Canada Research Chair in Cancer Signalling and Structural Biology, 2016