Principal Investigator

Sébastien Lemieux

Functional and Structural Bioinformatics

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Sébastien Lemieux was trained in both biology and computer sciences, earning a PhD in computer sciences from Université de Montréal in 2002, followed by a postdoctoral fellowship in the pharmaceutical industry. He joined IRIC in 2005.

Since arriving at the institute, he has contributed to numerous productive collaborations with his IRIC colleagues, notably within the Leucegene program, whose bioinformatics efforts he has led since 2008. He also serves as scientific director of IRIC’s bioinformatics platform.

His laboratory develops bioinformatics algorithms and artificial intelligence methods for the analysis of transcriptomics, proteomics, and high-throughput chemical screening data, with fundamental and translational applications aimed at supporting the development of new therapies. He is an associate academic member of Mila, scientific director of Calcul Québec, and director of the undergraduate bioinformatics program at Université de Montréal.

Principal Investigator, Functional and Structural Bioinformatics Research Unit, IRIC
Bioinformatics Core Facility direction

Associate Professor, Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal

Research unit on functional and structural bioinformatics

Marcelle-Coutu Pavilion, 3306-9

Phone (office)
(514) 343-6111, ext. 0635
Fax
(514) 343-7780
Email
s.lemieux@umontreal.ca
Apply for a M.Sc. or a Ph.D.

Functional and Structural Bioinformatics

Sébastien Lemieux and his team develop bioinformatics algorithms and artificial intelligence methods for the analysis of transcriptomics, proteomics, and high-throughput chemical screening data.

Discover the research unit View the research team

Research topics

  • Bioinformatics and Artificial Intelligence

Publications

  • July 2, 2026

    A transparent and generalizable deep-learning framework for genomic ancestry prediction.

    Rochefort-Boulanger C, Scicluna M, Poujol R, Grenier JC, Carrier PL, Lemieux S, Hussin JG
    Am J Hum Genet 2026-07-02 ;113( 7 ):1461-1477

  • June 11, 2026

    STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.

    Fahmy AM, Ahmadi A, Lanoix J, Cannon T, Elemeery MN, Paredes CH, Barrette B, Bonneil E, Xu YZ, Ibrahim M, Arango-Duque G, Audemard EO, Lemieux S, Chevet E, Schurr E, Pierre P, Gruenheid S, Thibault P, McBride HM, Desjardins M
    Cell Rep 2026-06-11 ;45( 6 ):117497

  • October 23, 2025

    High IL1R1 expression predicts poor survival and benefit from stem cell transplant in intermediate-risk acute myeloid leukemia from the Leucegene cohort.

    Richard-Carpentier G, Béliveau F, Lacoste S, Khakipoor B, Lisi V, Vladovsky M, Marquis M, Spinella JF, Gendron P, Lemieux S, Lavallée VP, Sauvageau G, Hébert J
    Biomark Res 2025-10-23 ;13( 1 ):133

  • May 22, 2025

    Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer.

    Apavaloaei A, Zhao Q, Hesnard L, Cahuzac M, Durette C, Larouche JD, Hardy MP, Vincent K, Brochu S, Laverdure JP, Lanoix J, Courcelles M, Gendron P, Lajoie M, Ruiz Cuevas MV, Kina E, Perrault J, Humeau J, Ehx G, Lemieux S, Watson IR, Speiser DE, Bassani-Sternberg M, Thibault P, Perreault C
    Nat Cancer 2025-05-22 ;

  • See all publications